LSE (liquid-solid extraction), MSPD (matrix solid phase dispersion) and QuEChERS (quick, easy, cheap, effective, rugged and safe) extractions followed by GC-μECD/NPD to determine 223 pesticide residues in tobacco simultaneously were developed and compared. The identities of ten model pesticides were confirmed by GC-MS/MS. The type and amount of dispersant (Florisil, silica gel and alumina), sample mass, cleanup adsorbent, and the eluent (hexane, acetone and acetonitrile) were optimized. Linearity, recovery, LOQ, LOD, and matrix effect were compared. Most recoveries were 71−120% (RSD < 18%). LOD and LOQ were much lower than the CORESTA GRLs. The best method was QuEChERS: acetonitrile extraction and dispersive solid-phase extraction using primary-secondary amine and graphitized carbon.
 Gupta A., Impact of Pesticides on Human and Ecosystem Health: Scientific, Ethical and Policy Issues, Proceedings of National Seminar on toxicity of Chemicals and their Hazards with Special Reference to heavy Metals (St. Edmund’s College, Shillong), 2008, 61-72.
 Ghelli J., Helio A., Martins-Jumor S.P., Andre S., Development of a fast and cost effective multi-residue method to determine pesticides in tobacco by LC/MS/MS, Technical note, 2009.
 Clapp W.L., Shelar G.R., The determination of chlorinated pesticides in mainstream smoke, 1972, http://legacy.library.ucsf.edu/tid/cdv69d00.
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