Claudia A.M. Gandini Wheeler‐Kingshott

article

Deep gray matter volume loss drives disability worsening in multiple sclerosis

Arman Eshaghi, Ferran Prados, Wallace J. Brownlee, Daniel R. Altmann, more

Annals of Neurology > 83 > 2 > 210 - 222

Objective Gray matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with faster disability accumulation in MS. Methods We analyzed 3,604 brain high‐resolution T1‐weighted magnetic resonance imaging scans from 1,417 participants: 1,214 MS patients (253 clinically isolated syndrome [CIS], 708...

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An optimized framework for quantitative magnetization transfer imaging of the cervical spinal cord in vivo

Marco Battiston, Francesco Grussu, Andrada Ianus, Torben Schneider, more

Magnetic Resonance in Medicine > 79 > 5 > 2576 - 2588

Purpose To develop a framework to fully characterize quantitative magnetization transfer indices in the human cervical cord in vivo within a clinically feasible time. Methods A dedicated spinal cord imaging protocol for quantitative magnetization transfer was developed using a reduced field‐of‐view approach with echo planar imaging (EPI) readout. Sequence parameters were optimized based in the...

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Urgent challenges in quantification and interpretation of brain grey matter atrophy in individual MS patients using MRI

Houshang Amiri, Alexandra de Sitter, Kerstin Bendfeldt, Marco Battaglini, more

NeuroImage: Clinical > 2018 > 19 > C > 466-475

Atrophy of the brain grey matter (GM) is an accepted and important feature of multiple sclerosis (MS). However, its accurate measurement is hampered by various technical, pathological and physiological factors. As a consequence, it is challenging to investigate the role of GM atrophy in the disease process as well as the effect of treatments that aim to reduce neurodegeneration. In this paper we discuss...

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Abnormal age-related cortical folding and neurite morphology in children with developmental dyslexia

Eduardo Caverzasi, Maria Luisa Mandelli, Fumiko Hoeft, Christa Watson, more

NeuroImage: Clinical > 2018 > 18 > C > 814-821

There is increasing recognition of a relationship between regional variability in cerebral gyrification and neurodevelopment. Recent work in morphometric MRI has shown that the local gyrification index (lGI), a measure of regional brain folding, may be altered in certain neurodevelopmental disorders. Other studies report that the lGI generally decreases with age in adolescence and young adulthood;...

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Spinal cord grey matter segmentation challenge

Ferran Prados, John Ashburner, Claudia Blaiotta, Tom Brosch, more

NeuroImage > 2017 > 152 > C > 312-329

An important image processing step in spinal cord magnetic resonance imaging is the ability to reliably and accurately segment grey and white matter for tissue specific analysis. There are several semi- or fully-automated segmentation methods for cervical cord cross-sectional area measurement with an excellent performance close or equal to the manual segmentation. However, grey matter segmentation...

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Machine learning based compartment models with permeability for white matter microstructure imaging

Gemma L. Nedjati-Gilani, Torben Schneider, Matt G. Hall, Niamh Cawley, more

NeuroImage > 2017 > 150 > C > 119-135

Some microstructure parameters, such as permeability, remain elusive because mathematical models that express their relationship to the MR signal accurately are intractable. Here, we propose to use computational models learned from simulations to estimate these parameters. We demonstrate the approach in an example which estimates water residence time in brain white matter. The residence time τ_i of...

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Cerebellar lobules and dentate nuclei mirror cortical force‐related‐BOLD responses: Beyond all (linear) expectations

Adnan A.S Alahmadi, Matteo Pardini, Rebecca S. Samson, Karl J. Friston, more

Human Brain Mapping > 38 > 5 > 2566 - 2579

The relationship between the BOLD response and an applied force was quantified in the cerebellum using a power grip task. To investigate whether the cerebellum responds in an on/off way to motor demands or contributes to motor responses in a parametric fashion, similarly to the cortex, five grip force levels were investigated under visual feedback. Functional MRI data were acquired in 13 healthy volunteers...

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A framework for optimal whole-sample histological quantification of neurite orientation dispersion in the human spinal cord

Francesco Grussu, Torben Schneider, Richard L. Yates, Hui Zhang, more

Journal of Neuroscience Methods > 2016 > 273 > C > 20-32

The complexity of fibre distributions in tissues is an important microstructural feature, now measurable in vivo by magnetic resonance imaging (MRI) through orientation dispersion (OD) indices. OD metrics have gained popularity for the characterisation of neurite morphology, but they still lack systematic validation. This paper demonstrates a framework for whole-sample histological quantification...

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A multi-time-point modality-agnostic patch-based method for lesion filling in multiple sclerosis

Ferran Prados, Manuel Jorge Cardoso, Baris Kanber, Olga Ciccarelli, more

NeuroImage > 2016 > 139 > C > 376-384

Multiple sclerosis lesions influence the process of image analysis, leading to tissue segmentation problems and biased morphometric estimates. Existing techniques try to reduce this bias by filling all lesions as normal-appearing white matter on T1-weighted images, considering each time-point separately. However, due to lesion segmentation errors and the presence of structures adjacent to the lesions,...

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Fully automated segmentation of the cervical cord from T1-weighted MRI using PropSeg: Application to multiple sclerosis

Marios C. Yiannakas, Ahmed M. Mustafa, Benjamin De Leener, Hugh Kearney, more

NeuroImage: Clinical > 2016 > 10 > C > 71-77

Spinal cord (SC) atrophy, i.e. a reduction in the SC cross-sectional area (CSA) over time, can be measured by means of image segmentation using magnetic resonance imaging (MRI). However, segmentation methods have been limited by factors relating to reproducibility or sensitivity to change. The purpose of this study was to evaluate a fully automated SC segmentation method (PropSeg), and compare this...

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Differential involvement of cortical and cerebellar areas using dominant and nondominant hands: An FMRI study

Adnan A.S. Alahmadi, Matteo Pardini, Rebecca S. Samson, Egidio D'Angelo, more

Human Brain Mapping > 36 > 12 > 5079 - 5100

Motor fMRI studies, comparing dominant (DH) and nondominant (NDH) hand activations have reported mixed findings, especially for the extent of ipsilateral (IL) activations and their relationship with task complexity. To date, no study has directly compared DH and NDH activations using an event‐related visually guided dynamic power‐grip paradigm with parametric (three) forces (GF) in healthy right‐handed...

INFONA - science communication portal

Search results for: Claudia A.M. Gandini Wheeler‐Kingshott

Deep gray matter volume loss drives disability worsening in multiple sclerosis

An optimized framework for quantitative magnetization transfer imaging of the cervical spinal cord in vivo

Urgent challenges in quantification and interpretation of brain grey matter atrophy in individual MS patients using MRI

Abnormal age-related cortical folding and neurite morphology in children with developmental dyslexia

Spinal cord grey matter segmentation challenge

Machine learning based compartment models with permeability for white matter microstructure imaging

Cerebellar lobules and dentate nuclei mirror cortical force‐related‐BOLD responses: Beyond all (linear) expectations

A framework for optimal whole-sample histological quantification of neurite orientation dispersion in the human spinal cord

A multi-time-point modality-agnostic patch-based method for lesion filling in multiple sclerosis

Fully automated segmentation of the cervical cord from T1-weighted MRI using PropSeg: Application to multiple sclerosis

Differential involvement of cortical and cerebellar areas using dominant and nondominant hands: An FMRI study

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INFONA - science communication portal

Search results for: Claudia A.M. Gandini Wheeler‐Kingshott

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