Search results for: Elżbieta Karczewska

Items from 1 to 13 out of 13 results

article

Promising anticonvulsant and/or analgesic compounds among 5‐chloro‐2‐ or 5‐chloro‐4‐methyl derivatives of xanthone coupled to aminoalkanol moieties—Design, synthesis and pharmacological evaluation

Gabriela Mazur, Katarzyna Pańczyk‐Straszak, Anna Rapacz, Jan Kiszela, more

Chemical Biology & Drug Design > 101 > 2 > 278 - 325

A series of 10 aminoalkanol derivatives of 5‐chloro‐2‐ or 5‐chloro‐4‐methylxanthone was synthetized and evaluated for anticonvulsant properties (MES test, mice, intraperitoneal) and compared with neurotoxicity rotarod test (NT, mice, i.p.). The best results both in terms of anticonvulsant activity and protective index value were obtained for 3: 5‐chloro‐2‐([4‐hydroxypiperidin‐1‐yl]methyl)‐9H‐xanthen‐9‐one...

article

Design, synthesis and activity against Staphylococcus epidermidis of 5‐chloro‐2‐ or 5‐chloro‐4‐methyl‐9H‐xanthen‐9‐one and some of its derivatives

Gabriela Mazur, Iwona Skiba‐Kurek, Elżbieta Karczewska, Katarzyna Pańczyk‐Straszak, more

Chemical Biology & Drug Design > 97 > 3 > 674 - 685

Ten new xanthone derivatives have been designed and synthesized for their potential antibacterial activity. All compounds have been screened against Staphylococcus epidermidis strains ATCC 12228 and clinical K/12/8915. The highest antibacterial activity was observed for compound 3: 5‐chloro‐2‐((4‐(2‐hydroxyethyl)piperazin‐1‐yl)methyl)‐9H‐xanthen‐9‐one dihydrochloride, exhibiting MIC of 0.8 µg/ml against...

article

Preliminary antifungal activity assay of selected chlorine‐containing derivatives of xanthone and phenoxyethyl amines

Karolina Klesiewicz, Dorota Żelaszczyk, Danuta Trojanowska, Bożena Bogusz, more

Chemical Biology & Drug Design > 92 > 5 > 1867 - 1875

The aim of this study was to evaluate antifungal activity in a diverse group of chlorine‐containing xanthone and phenoxyethyl amine derivatives – and to select the most promising compounds for further studies. The antifungal efficacy of 16 compounds was tested with qualitative and quantitative methods against both reference and clinical strains of dermatophytes, moulds and yeasts. The disc‐diffusion...

article

Prevalence of human pathogens of the clade Nakaseomyces in a culture collection—the first report on Candida bracarensis in Poland

Marianna Małek, Paulina Mrowiec, Karolina Klesiewicz, Iwona Skiba-Kurek, more

Folia Microbiologica > 2019 > 64 > 3 > 307-312

Human pathogens belonging to the Nakaseomyces clade include Candida glabrata sensu stricto, Candida nivariensis and Candida bracarensis. Their highly similar phenotypic characteristics often lead to misidentification by conventional laboratory methods. Therefore, limited information on the true epidemiology of the Candida glabrata species complex is available. Due to life-threatening infections caused...

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COMPARATIVE IN VITRO STUDIES OF FURAZIDIN AND NITROFURANTOIN ACTIVITIES AGAINST COMMON UROPATHOGENS INCLUDING MULTIDRUG-RESISTANT STRAINS OF E. COLI AND S. AUREUS

Karolina Klesiewicz, Elżbieta Karczewska, Paweł Nowak, Paulina M. Mrowiec, more

Acta Poloniae Pharmaceutica - Drug Research > 2018 > 75 > 3

Abstract: Urinary tract infections caused by wide range of pathogens including gram-negative and gram-positive bacteria as well as fungi are a severe public health problem. The predominant causative agent of both uncomplicated and complicated urinary tract infections is Escherichia coli. In an era of increasing bacterial resistance to antimicrobial agents and a high prevalence of multidrug-resistant...

article

PCR-RFLP detection of point mutations A2143G and A2142G in 23S rRNA gene conferring resistance to clarithromycin in Helicobacter pylori strains

Karolina Klesiewicz, Paweł Nowak, Elżbieta Karczewska, Iwona Skiba, more

Acta Biochimica Polonica > 2014 > 61 > 2 > 311-315

Background. The occurrence of clarithromycin resistance among Helicobacter pylori strains is a major cause of the treatment failure. Resistance to this drug is conferred by point mutations in 23S rRNA gene and the most prevalent mutations are A2143G and A2142G. The aim of the study was to evaluate the occurrence of A2143G and A2142G mutations in a group of H. pylori strains resistant to clarithromycin...

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186 Beneficial Effects of Probiotic Saccharomyces boulardi and Rifaximine in Stress- and NSAID-Induced Exacerbation of Experimental Colitis

Malgorzata M. Zwolinska-Wcislo, Peter C. Konturek, Danuta Drozdowicz, Elzbieta Karczewska, more

Gastroenterology > 2012 > 142 > 5 Supplement 1 > S-46

article

Oral Cavity as a Potential Source of Gastric Reinfection by Helicobacter pylori

Elżbieta Karczewska, Joanna E. Konturek, Peter C. Konturek, Marta Cześnikiewicz, more

Digestive Diseases and Sciences > 2002 > 47 > 5 > 978-986

Helicobacter pylori (Hp) is a common pathogen colonizing the a gastric mucosa, but some reports indicated that it may also be found in the oral cavity, which could serve as a reservoir of the bacteria and a source of gastric reinfection. Accordingly, we aimed to study whether the oral cavity, particularly gingival pockets, are colonized by Hp and whether it could be the source of gastric...

article

Functional aspects of gastric infection with Helicobacter pylori in Mongolian gerbils at early stage of adenocarcinoma formation

Tomasz Brzozowski, Peter C. Konturek, Jerzy Stachura, Elzbieta Karczewska, more

Gastroenterology > 2001 > 120 > 5 Supplement 1 > A163

article

Gastrin and cyclooxygenase-2 (COX-2) expression in Helicobacter pylori (Hp) infected gastric ulceration

Stanislaw J. Konturek, Peter C. Konturek, Wladyslaw Bielanski, Aleksandra Duda, more

Gastroenterology > 2001 > 120 > 5 Supplement 1 > A727

article

Gastrin and cyclooxygenase-2 (COX-2) expression in Helicobacter pylori (Hp) infected gastric ulceration

Stanislaw J. Konturek, Peter C. Konturek, Wladyslaw Bielanski, Aleksandra Duda, more

Gastroenterology > 2001 > 120 > 5 Supplement 1 > A727

article

Functional aspects of gastric infection with Helicobacter pylori in Mongolian gerbils at early stage of adenocarcinoma formation

Tomasz Brzozowski, Peter C. Konturek, Jerzy Stachura, Elzbieta Karczewska, more

Gastroenterology > 2001 > 120 > 5 Supplement 1 > A163

article

Expression of apoptosis related proteins bax and bcl-2 and growth factors in human gastric adenocarcinoma

Peter Ch Konturek, Elzbieta Karczewska, T. Starzynska, K. Marlicz, more

Gastroenterology > 2000 > 118 > 4 Part 1 > A759

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Search results for: Elżbieta Karczewska

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