Search results for: Edmund Grześkowiak

Items from 1 to 17 out of 17 results

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Population Pharmacokinetic Model of Dexmedetomidine in a Heterogeneous Group of Patients

Justyna Ber, Paweł Wiczling, Marcin Hołysz, Agnieszka Klupczyńska, more

The Journal of Clinical Pharmacology > 60 > 11 > 1461 - 1473

Dexmedetomidine is a hepatically eliminated drug with sedative, anxiolytic, sympatholytic, and analgesic properties that has been increasingly used for various indications in the form of a short or continuous intravenous infusion. This study aimed to propose a population pharmacokinetic (PK) model of dexmedetomidine in a heterogeneous group of intensive care unit patients, incorporating 29 covariates...

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Population analysis to assess the influence of age and body weight on pharmacokinetics and pharmacodynamics of dexmedetomidine in New Zealand White rabbits

Justyna Warzybok, Agnieszka Bienert, Agnieszka Borsuk‐De Moor, Włodzimierz Płotek, more

Biopharmaceutics & Drug Disposition > 41 > 7 > 307 - 316

The purpose of this work was i) to develop a population pharmacokinetic (PK) and pharmacodynamic (PD) model of dexmedetomidine (DEX) in New Zealand White rabbits, ii) to investigate the influence of the age and weight of the animals on the model parameters, and iii) to assess the linearity of DEX PKs in the examined dose range. This was a prospective, crossover study, using a total of 18 New Zealand...

article

Analgesic efficacy and safety of tapentadol in comparison with oxycodone in patients after open abdominal hysterectomy.

Dorota Kołodziej, Danuta Szkutnik-Fiedler, Ryszard Bosacki, Michał Michalak, more

Acta Poloniae Pharmaceutica - Drug Research > 2020 > 77 > 3 > 505-514

Tapentadol is the newest opioid with dual mechanism of action, that gives the potential to spare some opioid-induced adverse events. Studies involving this drug in acute pain are not numerous. The aim of this study was to compare the efficacy and tolerance of tapentadol and oxycodone in patients after abdominal hysterectomy. Patients were randomly allocated into two groups receiving: I. tapentadol...

article

PHARMACOKINETIC INTERACTION AFTER ORAL COADMINISTRATION OF CLARITHROMYCIN AND THE TYROSINE KINASE INHIBITOR LAPATINIB IN RATS

Agnieszka Karbownik, Joanna Porażka, Anna Łuczak, Artur Teżyk, more

Acta Poloniae Pharmaceutica - Drug Research > 2019 > 76 > 4 > 645-651

article

Influence of Obesity and Type 2 Diabetes Mellitus on the Pharmacokinetics of Tramadol After Single Oral Dose Administration

Joanna Porażka, Edyta Szałek, Wojciech Połom, Mateusz Czajkowski, more

European Journal of Drug Metabolism and Pharmacokinetics > 2019 > 44 > 4 > 579-584

Background and Objectives The number of overweight, obese and diabetic patients is constantly increasing. Metabolic disorders may affect the pharmacokinetics of drugs, e.g., by altering the activity of cytochrome P450 (CYP) isoenzymes. Tramadol is a commonly used analgesic metabolised mainly via CYP2D6 to its active metabolite, O-desmethyltramadol. The aim of the study was to assess the influence...

article

The Influence of Diabetes Mellitus on Glucuronidation and Sulphation of Paracetamol in Patients with Febrile Neutropenia

Anna Stachowiak, Edyta Szałek, Agnieszka Karbownik, Anna Łojko, more

European Journal of Drug Metabolism and Pharmacokinetics > 2019 > 44 > 2 > 289-294

Background and Objectives Numerous studies have confirmed the influence of diabetes mellitus on the pharmacokinetics of drugs. Paracetamol (APAP) is an antipyretic that is commonly used in febrile neutropenia (FN) therapy. APAP is chiefly metabolised by glucuronidation and sulphation. This study assessed the influence of diabetes on the pharmacokinetics of paracetamol and its metabolites: glucuronide...

article

The concomitant use of lapatinib and paracetamol - the risk of interaction

Agnieszka Karbownik, Edyta Szałek, Katarzyna Sobańska, Tomasz Grabowski, more

Investigational New Drugs > 2018 > 36 > 5 > 819-827

Summary Lapatinib is a tyrosine kinase inhibitor used for the treatment of breast cancer. Paracetamol is an analgesic commonly applied to patients with mild or moderate pain and fever. Cancer patients are polymedicated, which involves high risk of drug interactions during therapy. The aim of the study was to assess the interaction between lapatinib and paracetamol in rats. The rats were divided into...

article

Pharmacokinetics of dexmedetomidine during analgosedation in ICU patients

Piotr Smuszkiewicz, Paweł Wiczling, Justyna Ber, Justyna Warzybok, more

Journal of Pharmacokinetics and Pharmacodynamics > 2018 > 45 > 2 > 277-284

Dexmedetomidine (DEX) is a fairly new alfa₂-agonist which has been increasingly used in recent years for analgosedation, mostly because it offers a unique ability of providing both moderate level of sedation and analgesia without respiratory depression. Despite of many papers published, there are still only a few concerning the PK of the drug given as long-term infusion in ICU patients. The aim of...

article

Pharmacokinetic drug-drug interaction between erlotinib and paracetamol: A potential risk for clinical practice

Agnieszka Karbownik, Edyta Szałek, Katarzyna Sobańska, Tomasz Grabowski, more

European Journal of Pharmaceutical Sciences > 2017 > 102 > C > 55-62

Erlotinib is a tyrosine kinase inhibitor available for the treatment of non-small cell lung cancer. Paracetamol is an analgesic agent, commonly used in cancer patients. Because these drugs are often co-administered, there is an increasing issue of interaction between them.The aim of the study was to investigate the effect of paracetamol on the pharmacokinetic parameters of erlotinib, as well as the...

article

The pharmacokinetics of propofol in ICU patients undergoing long‐term sedation

Piotr Smuszkiewicz, Paweł Wiczling, Krzysztof Przybyłowski, Agnieszka Borsuk, more

Biopharmaceutics & Drug Disposition > 37 > 8 > 456 - 466

The aim of this study was to characterize the pharmacokinetics (PK) of propofol in ICU patients undergoing long‐term sedation and to assess the influence of routinely collected covariates on the PK parameters. Propofol concentration–time profiles were collected from 29 patients. Non‐linear mixed‐effects modelling in NONMEM 7.2 was used to analyse the observed data. The propofol pharmacokinetics was...

article

Influence of the Time of Intravenous Administration of Paracetamol on its Pharmacokinetics and Ocular Disposition in Rabbits

Agnieszka Karbownik, Agnieszka Bienert, Włodzimierz Płotek, Tomasz Grabowski, more

European Journal of Drug Metabolism and Pharmacokinetics > 2017 > 42 > 3 > 489-498

Background and Objectives Paracetamol is one of the most common analgesics and antipyretics applied in health care. The aim of the study was to investigate the influence of the time-of-day administration on the paracetamol pharmacokinetics and its penetration into aqueous humour (AH). Methods Rabbits were divided into three groups: I—receiving paracetamol at 08.00 h, II—receiving paracetamol at...

article

The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priors

Paweł Wiczling, Alicja Bartkowska-Śniatkowska, Oliwia Szerkus, Danuta Siluk, more

Journal of Pharmacokinetics and Pharmacodynamics > 2016 > 43 > 3 > 315-324

The purpose of this study was to assess the pharmacokinetics of dexmedetomidine in the ICU settings during the prolonged infusion and to compare it with the existing literature data using the Bayesian population modeling with literature-based informative priors. Thirty-eight patients were included in the analysis with concentration measurements obtained at two occasions: first from 0 to 24 h after...

article

Pharmacokinetics of sufentanil during long‐term infusion in critically ill pediatric patients

Alicja Bartkowska‐Śniatkowska, Agnieszka Bienert, Paweł Wiczling, Jowita Rosada‐Kurasińska, more

The Journal of Clinical Pharmacology > 56 > 1 > 109 - 115

The aim of this study was to develop a population pharmacokinetic model of sufentanil and to assess the influence of covariates in critically ill children admitted to a pediatric intensive care unit. After institutional approval, 41 children were enrolled in the study. Blood samples for pharmacokinetic (PK) assessment were collected from routinely placed arterial catheters during and after discontinuation...

article

Pharmacokinetics and pharmacodynamics of propofol in cancer patients undergoing major lung surgery

Krzysztof Przybyłowski, Joanna Tyczka, Damian Szczesny, Agnieszka Bienert, more

Journal of Pharmacokinetics and Pharmacodynamics > 2015 > 42 > 2 > 111-122

Despite the growing number of cancer cases and cancer surgeries around the world, the pharmacokinetics (PK) and pharmacodynamics (PD) of anesthetics used in this population are poorly understood. Patients operated due to cancer are usually in severe state and often require chemotherapy. It might affect the PK/PD of drugs used in this population. Therefore, in this study we explored the PK/PD...

article

The effect of sunitinib on the plasma exposure of intravenous paracetamol and its major metabolite: paracetamol glucuronide

Agnieszka Karbownik, Edyta Szałek, Katarzyna Sobańska, Wojciech Połom, more

European Journal of Drug Metabolism and Pharmacokinetics > 2015 > 40 > 2 > 163-170

The study aimed to examine the effect of sunitinib on the plasma exposure of intravenous paracetamol and its major metabolite, paracetamol glucuronide. Both drugs share metabolic pathways in the liver, and the drug interactions between sunitinib and paracetamol administered in higher doses were reported. These interactions resulted in hepatotoxicity. The adult New Zealand male rabbits were divided...

article

Clinical pharmacokinetics of ketoprofen enantiomers in wild type of Cyp 2c8 and Cyp 2c9 patients with rheumatoid arthritis

Franciszek Główka, Marta Karaźniewicz-Łada, Edmund Grześkowiak, Dominika Rogozinska, more

European Journal of Drug Metabolism and Pharmacokinetics > 2011 > 36 > 3 > 167-173

Pharmacokinetics of ketoprofen (KTP) enantiomers has been studied in patients with rheumatoid arthritis (RA) following administration of a single oral dose of 100 mg rac-KTP during multidrug therapy taking into consideration the genotype of RA patients Concentrations of (−)-R and (+)-S enantiomers of KTP in plasma, urine and synovial fluid samples were determined using a validated HPCE method. The...

article

Assessing circadian rhythms in propofol PK and PD during prolonged infusion in ICU patients

Agnieszka Bienert, Krzysztof Kusza, Katarzyna Wawrzyniak, Edmund Grześkowiak, more

Journal of Pharmacokinetics and Pharmacodynamics > 2010 > 37 > 3 > 289-304

This study evaluates possible circadian rhythms during prolonged propofol infusion in patients in the intensive care unit. Eleven patients were sedated with a constant propofol infusion. The blood samples for the propofol assay were collected every hour during the second day, the third day, and after the termination of the propofol infusion. Values of electroencephalographic bispectral index (BIS),...

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Keywords

DEXMEDETOMIDINE (4)
PHARMACOKINETICS (4)
PARACETAMOL (3)
PROPOFOL (3)
PARACETAMOL GLUCURONIDE (2)
PHARMACODYNAMICS (2)
POPULATION PHARMACOKINETICS (2)
SEDATION (2)
AAI INDEX (1)
ABDOMINAL HYSTERECTOMY (1)
AGING (1)
BIOAVAILABILITY (1)
CANCER PATIENTS (1)
CAPILLARY ZONE ELECTROPHORESIS (1)
CIRCADIAN RHYTHM (1)
CRITICAL ILL CHILDREN (1)
CYTOCHROME P450 (1)
DRUG-DRUG INTERACTION (1)
ERLOTINIB (1)
ICU (1)
INFORMATIVE PRIORS (1)
INTENSIVE CARE UNIT (1)
LAPATINIB (1)
LONG‐TERM SEDATION (1)
MAJOR LUNG SURGERY (1)
MECHANICAL VENTILATION (1)
NEW ZEALAND WHITE RABBITS (1)
OSI420 (1)
OXYCODONE (1)
PARACETAMOL GLUCURONIDE AND PARACETAMOL SULPHATE PHARMACOKINETICS (1)
PARACETAMOL SULPHATE (1)
PHARMACOGENETICS (1)
PHARMACOKINETIC (1)
PK/PD (1)
POPULATION APPROACH (1)
POPULATION PK (1)
POSTOPERATIVE PAIN (1)
RABBITS (1)
SEDATION MONITORING (1)
STEREOSELECTIVE PHARMACOKINETICS (1)
SUFENTANIL (1)
SUNITINIB (1)
TAPENTADOL (1)
WINBUGS (1)
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Data set

Springer (10)
Wiley (4)
PSJD (2)
Elsevier (1)

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Search results for: Edmund Grześkowiak

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