Search results for: Ágnes Kittel

Items from 1 to 20 out of 33 results

article

Radio-detoxified LPS alters bone marrow-derived extracellular vesicles and endothelial progenitor cells

Hargita Hegyesi, Nikolett Sándor, Géza Sáfrány, Virág Lovas, more

Stem Cell Research & Therapy > 2019 > 10 > 1 > 1-12

Stem cell-based therapies raise hope for cell replacement and provide opportunity for cardiac regenerative medicine and tumor therapy. Extracellular vesicles are a membrane-enclosed intercellular delivery system with the potential to improve the therapeutic efficacy of the treatment of a variety of disorders. As the incidence of breast cancer continues to rise, radiotherapy has emerged as a leading...

article

Microglia control the spread of neurotropic virus infection via P2Y12 signalling and recruit monocytes through P2Y12-independent mechanisms

Rebeka Fekete, Csaba Cserép, Nikolett Lénárt, Krisztina Tóth, more

Acta Neuropathologica > 2018 > 136 > 3 > 461-482

Neurotropic herpesviruses can establish lifelong infection in humans and contribute to severe diseases including encephalitis and neurodegeneration. However, the mechanisms through which the brain’s immune system recognizes and controls viral infections propagating across synaptically linked neuronal circuits have remained unclear. Using a well-established model of alphaherpesvirus infection that...

article

Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers

Andrzej Małecki, Janina Skipor-Lahuta, Michal Toborek, N. Joan Abbott, more

Fluids and Barriers of the CNS > 2017 > 14 > 2 > 1-23

article

Claudin peptidomimetics modulate tissue barriers for enhanced drug delivery

Sophie Dithmer, Christian Staat, Carolin Müller, Min‐Chi Ku, more

Annals of the New York Academy of Sciences > 1397 > 1 > 169 - 184

The blood–brain barrier (BBB) formed by the microvascular endothelium limits cerebral drug delivery. The paraendothelial cleft is sealed by tight junctions (TJs) with a major contribution from claudin‐5, which we selected as a target to modulate BBB permeability. For this purpose, drug‐enhancer peptides were designed based on the first extracellular loop (ECL) of claudin‐5 to allow transient BBB permeabilization...

article

Extracellular vesicles regulate the human osteoclastogenesis: divergent roles in discrete inflammatory arthropathies

Nikolett Marton, Orsolya Tünde Kovács, Eszter Baricza, Ágnes Kittel, more

Cellular and Molecular Life Sciences > 2017 > 74 > 19 > 3599-3611

Objective Extracellular vesicles (EVs) are subcellular signalosomes. Although characteristic EV production is associated with numerous physiological and pathological conditions, the effect of blood-derived EVs on bone homeostasis is unknown. Herein we evaluated the role of circulating EVs on human osteoclastogenesis. Methods Blood samples from healthy volunteers, rheumatoid arthritis (RA) and psoriatic...

article

Effect of rat spinal cord injury (hemisection) on the ex vivo uptake and release of [3H]noradrenaline from a slice preparation

Zoltán Borbély, Benedek Krisztián Csomó, Ágnes Kittel, Gábor Gerber, more

Brain Research Bulletin > 2017 > 131 > C > 150-155

We measured the ex vivo uptake and release of [³H]noradrenaline ([³H]NA) from perfused rat spinal cord slice preparations at 1, 3 and 14days after unilateral hemisection-induced spinal cord injury (SCI) compared with control slice preparations.After surgical hemisection under anaesthesia, the rats showed characteristic signs of hemiplegia, with no movement of the ipsilateral hindlimb. After 3days,...

article

Novel (Hetero)arylalkenyl propargylamine compounds are protective in toxin-induced models of Parkinson’s disease

Mária Baranyi, Pier Francesca Porceddu, Flóra Gölöncsér, Szabina Kulcsár, more

Molecular Neurodegeneration > 2016 > 11 > 1 > 1-21

Background Mitochondrial dysfunction, oxidative stress and their interplay are core pathological features of Parkinson’s disease. In dopaminergic neurons, monoamines and their metabolites provide an additional source of reactive free radicals during their breakdown by monoamine oxidase or auto-oxidation. Moreover, mitochondrial dysfunction and oxidative stress have a supraadditive impact on the pathological,...

article

Learned helplessness paradigm in P2xr7 wild type and knock out mice and its effect on synapses in the dentate gyrus

Lilla Otrokocsi, Flóra Gölöncsér, Beáta Sperlágh, Ágnes Kittel

SpringerPlus > 2015 > 4 > 1 > 1-32

article

Investigation of P2X7R involvement in maternal poly(i:C) exposure evoked autistic features in mice

Gergely Horváth, Lilla Otrokocsi, Ágnes Kittel, Mária Baranyi, more

SpringerPlus > 2015 > 4 > 1 > 1-32

article

Sucrose Esters Increase Drug Penetration, But Do Not Inhibit P‐Glycoprotein in Caco‐2 Intestinal Epithelial Cells

Lóránd Kiss, Éva Hellinger, Ana‐Maria Pilbat, Ágnes Kittel, more

Journal of Pharmaceutical Sciences > 103 > 10 > 3107 - 3119

Sucrose fatty acid esters are increasingly used as excipients in pharmaceutical products, but few data are available on their toxicity profile, mode of action, and efficacy on intestinal epithelial models. Three water‐soluble sucrose esters, palmitate (P‐1695), myristate (M‐1695), laurate (D‐1216), and two reference absorption enhancers, Tween 80 and Cremophor RH40, were tested on Caco‐2 cells. Caco‐2...

article

Cardioprotection by remote ischemic preconditioning of the rat heart is mediated by extracellular vesicles

Zoltán Giricz, Zoltán V. Varga, Tamás Baranyai, Péter Sipos, more

Journal of Molecular and Cellular Cardiology > 2014 > 68 > Complete > 75-78

Remote ischemic preconditioning (RIPC) of the heart is exerted by brief ischemic insults affected on a remote organ or a remote area of the heart before a sustained cardiac ischemia. To date, little is known about the inter-organ transfer mechanisms of cardioprotection by RIPC. Exosomes and microvesicles/microparticles are vesicles of 30–100nm and 100–1000nm in diameter, respectively (collectively...

article

Critical role of extracellular vesicles in modulating the cellular effects of cytokines

Géza Tamás Szabó, Bettina Tarr, Krisztina Pálóczi, Katalin Éder, more

Cellular and Molecular Life Sciences > 2014 > 71 > 20 > 4055-4067

Under physiological and pathological conditions, extracellular vesicles (EVs) are present in the extracellular compartment simultaneously with soluble mediators. We hypothesized that cytokine effects may be modulated by EVs, the recently recognized conveyors of intercellular messages. In order to test this hypothesis, human monocyte cells were incubated with CCRF acute lymphoblastic leukemia cell...

article

The recently identified hexosaminidase D enzyme substantially contributes to the elevated hexosaminidase activity in rheumatoid arthritis

Mária Pásztói, Barbara Sódar, Petra Misják, Krisztina Pálóczi, more

Immunology Letters > 2013 > 149 > 1-2 > 71-76

Since the 1970s, numerous reports have described elevated hexosaminidase activities in rheumatoid arthritis. However, due to the overlapping substrate specificities of different hexosaminidases, identification of the exact enzyme(s) responsible for the elevated activity remains incomplete.In this work we tested if the recently described enzyme, hexosaminidase D was expressed in human arthritic joints,...

article

Retinoic acid and hydrocortisone strengthen the barrier function of human RPMI 2650 cells, a model for nasal epithelial permeability

Levente Kürti, Szilvia Veszelka, Alexandra Bocsik, Béla Ózsvári, more

Cytotechnology > 2013 > 65 > 3 > 395-406

The nasal pathway represents an alternative route for non-invasive systemic administration of drugs. The main advantages of nasal drug delivery are the rapid onset of action, the avoidance of the first-pass metabolism in the liver and the easy applicability. In vitro cell culture systems offer an opportunity to model biological barriers. Our aim was to develop and characterize an in vitro model based...

article

The medial habenula contains a specific nonstellate subtype of astrocyte expressing the ectonucleotidase NTPDase2

Kristine Gampe, Klaus Hammer, Ágnes Kittel, Herbert Zimmermann

Glia > 60 > 12 > 1860 - 1870

ATP‐mediated synaptic transmission represents the only transmitter‐gated Ca²⁺‐entry pathway in neurons of the rodent medial habenula. In addition to direct purinergic receptor‐mediated synaptic inputs, the medial habenula contains purinergic systems that modulate synaptic transmission. Purinergic signaling is modulated or terminated by ectonucleotidase, nucleotide‐hydrolyzing enzymes of the cell surface...

article

Presynaptic α2-adrenoceptors control the inhibitory action of presynaptic CB1 cannabinoid receptors on prefrontocortical norepinephrine release in the rat

Hardy Richter, Filipe M. Teixeira, Samira G. Ferreira, Ágnes Kittel, more

Neuropharmacology > 2012 > 63 > 5 > 784-797

Endocannabinoids play a crucial neuromodulator role in both physiological and pathological states in various brain regions including the prefrontal cortex (PFC). We examined, whether presynaptic cannabinoid receptors are involved in the modulation of basal and electrical field stimulation-evoked [ ³ H]norepinephrine ([ ³ H]NE) release from rat PFC slices. WIN55,212-2, a nonselective...

article

Comparison of brain capillary endothelial cell-based and epithelial (MDCK-MDR1, Caco-2, and VB-Caco-2) cell-based surrogate blood–brain barrier penetration models

Éva Hellinger, Szilvia Veszelka, Andrea E. Tóth, Fruzsina Walter, more

European Journal of Pharmaceutics and Biopharmaceutics > 2012 > 82 > 2 > 340-351

An accurate means of predicting blood–brain barrier (BBB) penetration and blood–brain partitioning of NCEs (new chemical entities) would fulfill a major need in pharmaceutical research. Currently, an industry-standard BBB drug penetration model is not available. Primary brain capillary endothelial cells, optionally co-cultured with astrocytes and/or pericytes, are the most valued models of BBB. For...

article

The effect of sucrose esters on a culture model of the nasal barrier

Levente Kürti, Szilvia Veszelka, Alexandra Bocsik, Ngo Thi Khue Dung, more

Toxicology in Vitro > 2012 > 26 > 3 > 445-454

Sucrose esters are effective solubilizers and there is an interest to use them as pharmaceutical excipients for nasal drug delivery. We have determined for the first time the non-toxic doses of laurate and myristate sucrose esters by four independent methods, and their effects on epithelial permeability using RPMI 2650 human nasal epithelial cell line. Based on real-time cell electronic sensing, MTT...

article

Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice

Lilla Turiák, Petra Misják, Tamás G. Szabó, Borbála Aradi, more

Journal of Proteomics > 2011 > 74 > 10 > 2025-2033

Several studies have characterized exosomes derived from different cell sources. In this work we set the goal of proteomic characterization of two less studied populations of membrane vesicles, microvesicles (100–800nm) and apoptotic bodies (>800nm) released by thymus cells of BALB/c mice. The vesicles were isolated by the combination of differential centrifugation and gravity driven multistep...

article

Oxygen–glucose deprivation increases the enzymatic activity and the microvesicle-mediated release of ectonucleotidases in the cells composing the blood–brain barrier

Stefania Ceruti, Laura Colombo, Giulia Magni, Francesca Viganò, more

Neurochemistry International > 2011 > 59 > 2 > 259-271

The blood–brain barrier (BBB), the dynamic interface between the nervous tissue and the blood, is composed by endothelial cells, pericytes and astrocytes. Extracellular nucleotides and nucleosides and their receptors (the purinergic system) constitute a widely diffused signaling system involved in many pathophysiological processes. However, the role of this system in controlling BBB functions is still...

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Search results for: Ágnes Kittel

Radio-detoxified LPS alters bone marrow-derived extracellular vesicles and endothelial progenitor cells

Microglia control the spread of neurotropic virus infection via P2Y12 signalling and recruit monocytes through P2Y12-independent mechanisms

Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers

Claudin peptidomimetics modulate tissue barriers for enhanced drug delivery

Extracellular vesicles regulate the human osteoclastogenesis: divergent roles in discrete inflammatory arthropathies

Effect of rat spinal cord injury (hemisection) on the ex vivo uptake and release of [3H]noradrenaline from a slice preparation

Novel (Hetero)arylalkenyl propargylamine compounds are protective in toxin-induced models of Parkinson’s disease

Learned helplessness paradigm in P2xr7 wild type and knock out mice and its effect on synapses in the dentate gyrus

Investigation of P2X7R involvement in maternal poly(i:C) exposure evoked autistic features in mice

Sucrose Esters Increase Drug Penetration, But Do Not Inhibit P‐Glycoprotein in Caco‐2 Intestinal Epithelial Cells

Cardioprotection by remote ischemic preconditioning of the rat heart is mediated by extracellular vesicles

Critical role of extracellular vesicles in modulating the cellular effects of cytokines

The recently identified hexosaminidase D enzyme substantially contributes to the elevated hexosaminidase activity in rheumatoid arthritis

Retinoic acid and hydrocortisone strengthen the barrier function of human RPMI 2650 cells, a model for nasal epithelial permeability

The medial habenula contains a specific nonstellate subtype of astrocyte expressing the ectonucleotidase NTPDase2

Presynaptic α2-adrenoceptors control the inhibitory action of presynaptic CB1 cannabinoid receptors on prefrontocortical norepinephrine release in the rat

Comparison of brain capillary endothelial cell-based and epithelial (MDCK-MDR1, Caco-2, and VB-Caco-2) cell-based surrogate blood–brain barrier penetration models

The effect of sucrose esters on a culture model of the nasal barrier

Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice

Oxygen–glucose deprivation increases the enzymatic activity and the microvesicle-mediated release of ectonucleotidases in the cells composing the blood–brain barrier

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