Search results for: Barbara Filipek

Items from 1 to 20 out of 64 results

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Wpływ aplikacji pulpy siarkowej na plonowanie i skład chemiczny kukurydzy

Aneta Lisowska, Barbara Filipek-Mazur, Bogdan Kulig

Przemysł Chemiczny > 2024 > T. 103, nr 1 > 143--148

Doświadczenie polowe prowadzono w latach 2018-2019 w Stacji Doświadczalnej Uniwersytetu Rolniczego w Krakowie. W pierwszym roku doświadczenie obejmowało 5 obiektów: obiekt kontrolny bez nawożenia, obiekt z nawożeniem pulpą siarkową oraz obiekty z nawożeniem pulpą siarkową w połączeniu z materiałami organicznymi. W drugim roku doświadczenie kontynuowano celem oceny dwóch strategii nawożenia: ponownego...

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Możliwość wykorzystania odpadowej pulpy siarkowej do produkcji nawozu

Aneta Lisowska, Monika Tabak, Barbara Filipek-Mazur

Przemysł Chemiczny > 2021 > T. 100, nr 11 > 1084--1088

Przedstawiono wyniki badania ankietowego, którego celem było określenie masy i kierunków zagospodarowania pulpy siarki pierwiastkowej otrzymywanej w Polsce w procesie odsiarczania biogazu pochodzącego z fermentacji osadów ściekowych. Określono podstawowe właściwości fizyczne prototypu granulatu nawozowego wytworzonego z pulpy siarki pierwiastkowej i granulowanego obornika bydlęcego. Stwierdzono, że...

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Właściwości preparatu kwasów huminowych Bio-activated Base actosol® i jego wpływ na plonowanie roślin

Barbara Filipek-Mazur, Monika Tabak, Grażyna Żukowska, Krystyna Ciarkowska, more

Przemysł Chemiczny > 2019 > T. 98, nr 6 > 920--923

Określono właściwości preparatu kwasów huminowych Bio-activated Base actosol® oraz wpływu jego doglebowej aplikacji na wielkość plonu kukurydzy i selera. Przeprowadzono dwuletnie doświadczenie wazonowe, w którym rośliny testowe (rosnące w monokulturach) uprawiano na glebach lekkiej i średniej. Badane kwasy huminowe charakteryzowały się małą alifatycznością, o czym świadczyły wartości stosunków absorbancji...

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Tridentate hydrazido-hydrazones vanadium complexes. Synthesis, properties and biological activity

Janusz Szklarzewicz, Anna Jurowska, Maciej Hodorowicz, Dariusz Matoga, more

Science, Technology and Innovation > 2019 > Vol. 4, no. 1 > 9--20

Nine new vanadium complexes, with tridentate Schiff base ligand based on 3,5-di-tertbutyl-2-hydroxybenzaldehyde and different hydrazides, are described and characterized. The X-ray crystal structure of complex 8 shows distorted octahedral geometry of vanadium, with ONO ligand in equatorial position. The tridentate Schiff base ligand forms six membered and five-membered chelate rings at the V(V) acceptor...

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Influence of sulfur and iron fertilization on nutrient utilization by plants

Monika Tabak, Barbara Filipek-Mazur

Infrastruktura i Ekologia Terenów Wiejskich > 2019 > nr II/1 > 53--65

The aim of the three-year pot experiment was to determine the effect of standard mineral fertilization enriched with sulfur and iron on the content of nitrogen and sulfur in plants and on nutrient utilization by plants. Abundance of sulfates in soil after sulfur fertilization was also assessed. The direct effect of fertilization was assessed during the first and second year of the pot experiment,...

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Anti-aggregation effect of aroxyalkyl derivatives of 2-methoxyphenylpiperazine is due to their 5-HT2A and α2-adrenoceptor antagonistic properties. A comparison with ketanserin, sarpogrelate, prazosin, yohimbine and ARC239

Monika Kubacka, Grzegorz Kazek, Magdalena Kotańska, Barbara Filipek, more

European Journal of Pharmacology > 2018 > 818 > C > 263-270

Serotonin (5-HT) and adrenaline acting at platelet 5-HT_2A-serotoninergic and α₂-adrenergic receptors are involved in platelet aggregation. We have evaluated the antagonistic potency at 5-HT_2A, α_2A–, and α_2B-adrenoceptors as well as an anti-aggregation effect of aroxyalkyl derivatives of 2-methoxyphenylpiperazine and compared them with ketanserin, sarpogrelate, prazosin, yohimbine and ARC239 (2-[2-[4-(o-methoxyphenyl)-piperazin-1-yl]-ethyl]-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione)...

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Biphenyloxy-alkyl-piperidine and azepane derivatives as histamine H3 receptor ligands

Dorota Łażewska, Maria Kaleta, J. Stephan Schwed, Tadeusz Karcz, more

Bioorganic & Medicinal Chemistry > 2017 > 25 > 20 > 5341-5354

Novel biphenyloxy-alkyl derivatives of piperidine and azepane were synthesized and evaluated for their binding properties at the human histamine H₃ receptor. Two series of compounds were obtained with a meta- and a para-biphenyl moiety. The alkyl chain spacer contained five and six carbon atoms. The highest affinity among all compounds was shown by 1-(6-(3-phenylphenoxy)hexyl)azepane (13) with a K...

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Comparative effects of lignite-derived humic acids and FYM on soil properties and vegetable yield

Krystyna Ciarkowska, Katarzyna Sołek-Podwika, Barbara Filipek-Mazur, Monika Tabak

Geoderma > 2017 > 303 > C > 85-92

The effects of a product containing lignite derived humic acids (Act) on medium and coarse textured soil properties and vegetable yield were verified through a 3-year pot experiment. This work sought to assess if a lignite derived humic acids product may substitute the use of manure considering its effects on soil properties and yields of vegetables. Both humic acids product in single (Act1) and double...

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Synthesis and evaluation of anticonvulsant properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and its 3-methyl-, 3-isopropyl, and 3-benzhydryl analogs

Sabina Rybka, Jolanta Obniska, Anna Rapacz, Barbara Filipek, more

Bioorganic & Medicinal Chemistry Letters > 2017 > 27 > 6 > 1412-1415

The aim of this paper was to describe the synthesis of a library of 28 new 1,3-substituted pyrrolidine-2,5-dione as potential anticonvulsant agents. The anticonvulsant activity was evaluated using three acute models of seizures in mice (MES-maximal electroshock, scPTZ-subcutaneous pentylenetetrazole, and 6Hz-psychomotor seizure tests). The neurotoxicity was determined by rotarod test. The most promising...

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Analgesic, antiallodynic, and anticonvulsant activity of novel hybrid molecules derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide in animal models of pain and epilepsy

Anna Rapacz, Krzysztof Kamiński, Jolanta Obniska, Paulina Koczurkiewicz, more

Naunyn-Schmiedeberg's Archives of Pharmacology > 2017 > 390 > 6 > 567-579

The purpose of the present study was to examine the analgesic activity of six novel hybrid molecules, which demonstrated in the previous research anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure (scPTZ) tests in mice. The antinociceptive properties were estimated in three models of pain in mice—the hot plate test, the formalin test, and...

article

Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH3 or 2-CH3

Agnieszka Gunia-Krzyżak, Dorota Żelaszczyk, Anna Rapacz, Ewa Żesławska, more

Bioorganic & Medicinal Chemistry > 2017 > 25 > 2 > 471-482

A series of twenty two (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH₃ or 2-CH₃ was designed, synthesized and evaluated for anticonvulsant activity in rodent models of seizures: maximal electroshock (MES) test, subcutaneous pentylenetetrazole (scPTZ) test, and 6-Hz test. There were identified three most active compounds: S-(2E)-N-(1-hydroxypropan-2-yl)-3-(2-methylphenyl)prop-2-enamide...

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The role of adenosine a2a receptors in antidepressant activity in an experimental animal model of depression

Anna DZIUBINA, Małgorzata ZYGMUNT, Barbara FILIPEK, Kinga SAŁAT, more

Medicina Internacia Revuo > 2017 > 28 > 109 > 228-236

Intensive studies on the role of adenosine A2A receptors in Parkinson’s disease have been carried out for many years,. These studies have indicated that the antagonists of these receptors not only alleviate motor deficits but also exhibit neuroprotective effects in various animal models. Little is known about the role of these receptors in ailments accompanying Parkinson’s disease, such as depression...

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Synthesis and activity of newly designed aroxyalkyl or aroxyethoxyethyl derivatives of piperazine on the cardiovascular and the central nervous systems

Anna Maria Waszkielewicz, Monika Kubacka, Katarzyna Pańczyk, Szczepan Mogilski, more

Bioorganic & Medicinal Chemistry Letters > 2016 > 26 > 21 > 5315-5321

In the search for new hypotensive agents some new aroxyalkyl or aroxyethoxyethyl derivatives of piperazine have been synthesized and evaluated for their pharmacological properties. Pharmacological tests included receptor binding assays toward adrenergic receptors α₁, α₂ and β₁, additionally 5-HT_1A, functional bioassay and in vivo evaluation of hypotensive activity as well as antidepressant-like potential...

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Aryl-1,3,5-triazine ligands of histamine H₄ receptor attenuate inflammatory and nociceptive response to carrageen, zymosan and lipopolysaccharide

Szczepan Mogilski, Monika Kubacka, Dorota Łażewska, Małgorzata Więcek, more

Inflammation Research > 2017 > 66 > 1 > 79-95

Objective and design Histamine H₄ receptor (H₄R) offers a great potential for new therapeutic strategies for the treatment of inflammation-based diseases. The aim of this study is to present the pharmacological profile of two recently synthesized ligands of H₄R with particular reference to their anti-inflammatory and analgesic activity. Materials and subjects We used mice and rats in the in vivo...

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HBK-7 — A new xanthone derivative and a 5-HT1A receptor antagonist with antidepressant-like properties

Karolina Pytka, Grzegorz Kazek, Agata Siwek, Barbara Mordyl, more

Pharmacology Biochemistry and Behavior > 2016 > 146-147 > C > 35-43

Xanthone derivatives possess many biological properties, including neuroprotective, antioxidant or antidepressant-like. In this study we aimed to investigate antidepressant- and anxiolytic-like properties of a new xanthone derivative – 6-methoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]-9H-xanthen-9-one (HBK-7), as well as its possible mechanism of action, and the influence on cognitive and motor function...

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Design, synthesis and anticonvulsant activity of new hybrid compounds derived from N-phenyl-2-(2,5-dioxopyrrolidin-1-yl)-propanamides and -butanamides

Krzysztof Kamiński, Anna Rapacz, Barbara Filipek, Jolanta Obniska

Bioorganic & Medicinal Chemistry > 2016 > 24 > 13 > 2938-2946

The focused library of 21 new N-phenyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide, 2-(3-methyl-2,5-dioxopyrrolidin-1-yl)propanamide, and 2-(2,5-dioxopyrrolidin-1-yl)butanamide derivatives as potential new hybrid anticonvulsant agents was synthesized. These hybrid molecules were obtained as close analogs of previously described N-benzyl derivatives and fuse the chemical fragments of clinically relevant...

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Anticonvulsant and antinociceptive activity of new amides derived from 3-phenyl-2,5-dioxo-pyrrolidine-1-yl-acetic acid in mice

Anna Rapacz, Jolanta Obniska, Beata Wiklik-Poudel, Sabina Rybka, more

European Journal of Pharmacology > 2016 > 781 > C > 239-249

The aim of the present experiments was to examine the anticonvulsant and antinociceptive activity of five new amides derived from 3-phenyl-2,5-dioxo-pyrrolidine-1-yl-acetic acid in animal models of seizures and pain. The antiseizure activity was investigated in three acute models of seizures, namely, the maximal electroshock (MES), the subcutaneous pentylenetetrazole (scPTZ), and 6Hz psychomotor seizure...

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Synthesis and evaluation of anticonvulsant properties of new N-Mannich bases derived from 3-(1-phenylethyl)- and 3-benzyl-pyrrolidine-2,5-dione

Sabina Rybka, Jolanta Obniska, Anna Rapacz, Anna Furgała, more

Bioorganic & Medicinal Chemistry Letters > 2016 > 26 > 9 > 2147-2151

Two series of new derivatives of pyrrolidine-2,5-dione were synthesized and evaluated for their anticonvulsant properties. Initial screening for their anticonvulsant properties was performed in mice after intraperitoneal administration, using the maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ) and 6-Hz seizure tests. Quantitative pharmacological research revealed that the highest...

article

Antidepressant-like activity of aroxyalkyl derivatives of 2-methoxyphenylpiperazine and evidence for the involvement of serotonin receptor subtypes in their mechanism of action

Monika Kubacka, Szczepan Mogilski, Marek Bednarski, Leszek Nowiński, more

Pharmacology Biochemistry and Behavior > 2016 > 141 > C > 28-41

Since serotonin (5-HT) is strongly involved in the etiology and pathophysiology of depression, the development of new antidepressants is still based on the serotonergic system. The complexity of serotonergic system provides an opportunity for the development of compounds with multiple and complementary mechanism of action. This study describes serotonin receptor profile, functional characterization,...

article

Evaluation of anticonvulsant and antinociceptive properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and 3-methylpyrrolidine-2,5-dione

Anna Rapacz, Sabina Rybka, Jolanta Obniska, Kinga Sałat, more

Naunyn-Schmiedeberg's Archives of Pharmacology > 2016 > 389 > 3 > 339-348

The aim of the present experiments was to examine anticonvulsant activity of new pyrrolidine-2,5-dione and 3-methylpyrrolidine-2,5-dione derivatives in animal models of epilepsy. In addition, the possible collateral antinociceptive activity was assessed. Anticonvulsant activity was investigated in the electroconvulsive threshold (MEST) test and the pilocarpine-induced seizure models in mice. Antinociceptive...

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INFONA - science communication portal

Search results for: Barbara Filipek

Wpływ aplikacji pulpy siarkowej na plonowanie i skład chemiczny kukurydzy

Możliwość wykorzystania odpadowej pulpy siarkowej do produkcji nawozu

Właściwości preparatu kwasów huminowych Bio-activated Base actosol® i jego wpływ na plonowanie roślin

Tridentate hydrazido-hydrazones vanadium complexes. Synthesis, properties and biological activity

Influence of sulfur and iron fertilization on nutrient utilization by plants

Anti-aggregation effect of aroxyalkyl derivatives of 2-methoxyphenylpiperazine is due to their 5-HT2A and α2-adrenoceptor antagonistic properties. A comparison with ketanserin, sarpogrelate, prazosin, yohimbine and ARC239

Biphenyloxy-alkyl-piperidine and azepane derivatives as histamine H3 receptor ligands

Comparative effects of lignite-derived humic acids and FYM on soil properties and vegetable yield

Synthesis and evaluation of anticonvulsant properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and its 3-methyl-, 3-isopropyl, and 3-benzhydryl analogs

Analgesic, antiallodynic, and anticonvulsant activity of novel hybrid molecules derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide in animal models of pain and epilepsy

Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH3 or 2-CH3

The role of adenosine a2a receptors in antidepressant activity in an experimental animal model of depression

Synthesis and activity of newly designed aroxyalkyl or aroxyethoxyethyl derivatives of piperazine on the cardiovascular and the central nervous systems

Aryl-1,3,5-triazine ligands of histamine H₄ receptor attenuate inflammatory and nociceptive response to carrageen, zymosan and lipopolysaccharide

HBK-7 — A new xanthone derivative and a 5-HT1A receptor antagonist with antidepressant-like properties

Design, synthesis and anticonvulsant activity of new hybrid compounds derived from N-phenyl-2-(2,5-dioxopyrrolidin-1-yl)-propanamides and -butanamides

Anticonvulsant and antinociceptive activity of new amides derived from 3-phenyl-2,5-dioxo-pyrrolidine-1-yl-acetic acid in mice

Synthesis and evaluation of anticonvulsant properties of new N-Mannich bases derived from 3-(1-phenylethyl)- and 3-benzyl-pyrrolidine-2,5-dione

Antidepressant-like activity of aroxyalkyl derivatives of 2-methoxyphenylpiperazine and evidence for the involvement of serotonin receptor subtypes in their mechanism of action

Evaluation of anticonvulsant and antinociceptive properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and 3-methylpyrrolidine-2,5-dione

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