Search results for: Loris G. Baggetto

Items from 1 to 8 out of 8 results

article

Regulation of brain endothelial cells migration and angiogenesis by P-glycoprotein/caveolin-1 interaction

Stéphane Barakat, Sandra Turcotte, Michel Demeule, Marie-Paule Lachambre, more

Biochemical and Biophysical Research Communications > 2008 > 372 > 3 > 440-446

We have investigated the involvement of P-glycoprotein (P-gp)/caveolin-1 interaction in the regulation of brain endothelial cells (EC) migration and tubulogenesis. P-gp overexpression in MDCK-MDR cells was correlated with enhanced cell migration whereas treatment with P-gp inhibitors CsA or PSC833 reduced it. Transfection of RBE4 rat brain endothelial cells with mutated versions of MDR1, in the caveolin-1...

article

Gene Therapy of the Typical Multidrug Resistance Phenotype of Cancers: A New Hope?

Stëphane Labialle, Guila Dayan, Mickaél Michaud, Stëphane Barakat, more

Seminars in Oncology > 2005 > 32 > 6 > 583-590

The multidrug resistance (MDR) phenotype of cancers has generated a large amount of research, owing to its constant fatal clinical outcome. Many studies have focused on the discovery of chemomodulators; however, in spite of this huge effort, the side effects that these products induce, and their additive toxicity when used in the presence of anticancer drugs, have led to the disaffection of the pharmaceutical...

article

Major cytogenetic aberrations and typical multidrug resistance phenotype of uveal melanoma: Current views and new therapeutic prospects

Loris G. Baggetto, Joël Gambrelle, Guila Dayan, Stéphane Labialle, more

Cancer Treatment Reviews > 2005 > 31 > 5 > 361-379

Uveal melanoma is the most frequent intra-ocular cancer. The recent development of new chromosome-related technologies have permitted the elucidation of both the cytogenetics and the natural history of this disease. Fifty to 60% of uveal melanomas are linked to a monosomy 3, which appears as an early and determinant event in tumor progression. Tumors with this anomaly have a very poor prognosis. Recent...

article

Control of P-Glycoprotein Activity by Membrane Cholesterol Amounts and Their Relation to Multidrug Resistance in Human CEM Leukemia Cells ^†

Landry Gayet, Guila Dayan, Stéphane Barakat, Stéphane Labialle, more

Biochemistry > 2005 > 44 > 11 > 4499 - 4509

article

Transcriptional regulators of the human multidrug resistance 1 gene: recent views

Stéphane Labialle, Landry Gayet, Eric Marthinet, Dominique Rigal, more

Biochemical Pharmacology > 2002 > 64 > 5-6 > 943-948

The multidrug resistance (MDR) phenotype is the major cause of failure of cancer chemotherapy. This phenotype is mainly due to the overexpression of the human MDR1 (hMDR1) gene. Several studies have shown that transcriptional regulation of this gene is unexpectedly complex and is far from being completely understood. Current work is aimed mainly at defining unclear and new control regions in the hMDR1...

article

In vitro and in vivo reversal of cancer cell multidrug resistance by the semi-synthetic antibiotic tiamulin - Assessment of chemosensitivity testing

Loris G. Baggetto, Maoqing Dong, Jeanine Bernaud, Leon Espinosa, more

Biochemical Pharmacology > 1998 > 56 > 9 > 1219-1228

A large number of multidrug resistance (MDR) modulators, termed chemosensitizers, have been identified from a variety of chemicals, but most have been proven to be clinically toxic. Low concentrations of the pleuromutilin-derived semi-synthetic antibiotic tiamulin (0.1 to 10 μM) sensitized the three highly resistant P-glycoprotein (Pgp)-overexpressing tumor cell lines P388 (murine lymphoid leukemia),...

article

Complete Removal and Exchange of Sodium Dodecyl Sulfate Bound to Soluble and Membrane Proteins and Restoration of Their Activities, Using Ceramic Hydroxyapatite Chromatography

Maoqing Dong, Loris G. Baggetto, Pierre Falson, Marc LeMaire, more

Analytical Biochemistry > 1997 > 247 > 2 > 333-341

Up to now, removal of sodium dodecyl sulfate (SDS) from proteins in terms of restoration of their activity was an unsolved problem. A general procedure using ceramic hydroxyapatite (HAP) chromatography was developed for the complete removal of SDS bound to soluble or membrane proteins. This procedure involves (i) the binding of the SDS–protein complexes onto the ceramic hydroxyapatite column, (ii)...

article

Biochemical, Genetic, and Metabolic Adaptations of Tumor Cells That Express the Typical Multidrug-Resistance Phenotype. Reversion by New Therapies

Loris G. Baggetto

Journal of Bioenergetics and Biomembranes > 1997 > 29 > 4 > 401-413

Among the genetic and metabolic alterations that cancer cells undergo, several allow their survival under extreme environmental conditions. The resulting aberrant metabolism is compatible with tumor progression at the expenses of high energy needs, especially for maintaining high division rates. When treated with chemotherapeutic drugs many cancer cells take advantage of their ability to develop a...

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