Search results for: Elena E. Pohl

Items from 1 to 20 out of 40 results

article

The 2‐oxoglutarate/malate carrier extends the family of mitochondrial carriers capable of fatty acid and 2,4‐dinitrophenol‐activated proton transport

Kristina Žuna, Tatyana Tyschuk, Taraneh Beikbaghban, Felix Sternberg, more

Aims Metabolic reprogramming in cancer cells has been linked to mitochondrial dysfunction. The mitochondrial 2‐oxoglutarate/malate carrier (OGC) has been suggested as a potential target for preventing cancer progression. Although OGC is involved in the malate/aspartate shuttle, its exact role in cancer metabolism remains unclear. We aimed to investigate whether OGC may contribute to the alteration...

article

UCP2 up-regulation within the course of autoimmune encephalomyelitis correlates with T-lymphocyte activation

Alina Smorodchenko, Stephanie Schneider, Anne Rupprecht, Karoline Hilse, more

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease > 2017 > 1863 > 4 > 1002-1012

Multiple sclerosis (MS) is an inflammatory demyelinating autoimmune disorder of the central nervous system (CNS) associated with severe neurological disability. Reactive oxygen species (ROS) and mitochondrial dysfunction play a pivotal role in the pathogenesis of this disease. Several members of the mitochondrial uncoupling protein subfamily (UCP2–UCP5) were suggested to regulate ROS by diminishing...

article

Protonation of Long Chain Fatty Acids at the Membrane-Water Interface

Alina A. Pashkovskaya, Mario Vazdar, Olga Jovanovic, Peter Pohl, more

Biophysical Journal > 2017 > 112 > 3 Supplement 1 > 520a

article

UCP2 regulation coincides with metabolic adaptation

Anne Rupprecht, Rudolf Moldzio, Elena E. Pohl

Biochimica et Biophysica Acta (BBA) - Bioenergetics > 2016 > 1857 > S > e114

article

Functions of UCP1 and UCP3 in brown adipose tissue – together or apart?

Karolina E. Hilse, Anastasia Kalinovich, Anne Rupprecht, Alina Smorodchenko, more

Biochimica et Biophysica Acta (BBA) - Bioenergetics > 2016 > 1857 > S > e94

article

Structural, biological and biophysical properties of glycated and glycoxidized phosphatidylethanolamines

Andrea Annibal, Thomas Riemer, Olga Jovanovic, Dennis Westphal, more

Free Radical Biology and Medicine > 2016 > 95 > C > 293-307

Glycation and glycoxidation of proteins and peptides have been intensively studied and are considered as reliable diagnostic biomarkers of hyperglycemia and early stages of type II diabetes. However, glucose can also react with primary amino groups present in other cellular components, such as aminophospholipids (aminoPLs). Although it is proposed that glycated aminoPLs can induce many cellular responses...

article

Binding Mechanism of Purine Nucleotides to Mitochondrial Uncoupling Proteins Explored by Recognition Force Spectroscopy

Melanie Koehler, Gabriel Macher, Anne Rupprecht, Rong Zhu, more

Biophysical Journal > 2016 > 110 > 3 Supplement 1 > 518a

article

The expression of UCP3 directly correlates to UCP1 abundance in brown adipose tissue

Karolina E. Hilse, Anastasia V. Kalinovich, Anne Rupprecht, Alina Smorodchenko, more

Biochimica et Biophysica Acta (BBA) - Bioenergetics > 2016 > 1857 > 1 > 72-78

UCP1 and UCP3 are members of the uncoupling protein (UCP) subfamily and are localized in the inner mitochondrial membrane. Whereas UCP1's central role in non-shivering thermogenesis is acknowledged, the function and even tissue expression pattern of UCP3 are still under dispute. Because UCP3 properties regarding transport of protons are qualitatively identical to those of UCP1, its expression in brown...

article

The molecular mechanism behind reactive aldehyde action on transmembrane translocations of proton and potassium ions

Olga Jovanovic, Alina A. Pashkovskaya, Andrea Annibal, Mario Vazdar, more

Free Radical Biology and Medicine > 2015 > 89 > C > 1067-1076

Membrane transporters are involved in enormous number of physiological and pathological processes. Under oxidative stress they become targets for reactive oxygen species and its derivatives which cause protein damage and/or influence protein function(s). The molecular mechanisms of this interaction are poorly understood. Here we describe a novel lipid-mediated mechanism by which biologically important...

article

Modified Aminophospholipids Strongly Alter the Function of Mitochondrial Membrane Protein UCP1

Olga Jovanovic, Nadine Burchardt, Lars Gille, Elena E. Pohl

Biophysical Journal > 2015 > 108 > 2 Supplement 1 > 254a-255a

article

Effect of Reactive Aldehydes on Ionophore-Mediated Transmembrane Translocations of H+ and K+

Alina A. Pashkovskaya, Elena E. Pohl

Biophysical Journal > 2015 > 108 > 2 Supplement 1 > 357a

article

Increased intracellular calcium level and impaired nutrient absorption are important pathogenicity traits in the chicken intestinal epithelium during Campylobacter jejuni colonization

Wageha A. Awad, Alina Smorodchenko, Claudia Hess, Jörg R. Aschenbach, more

Applied Microbiology and Biotechnology > 2015 > 99 > 15 > 6431-6441

Although a high number of chickens carry Campylobacter jejuni, the mechanistic action of colonization in the intestine is still poorly understood. The current study was therefore designed to investigate the effects of C. jejuni on glucose uptake, amino acids availability in digesta, and intracellular calcium [Ca²⁺]_i signaling in the intestines of broiler chickens. For this, we compared: control birds...

article

Chemodiversity of cereulide, the emetic toxin of Bacillus cereus

Sandra Marxen, Timo D. Stark, Elrike Frenzel, Andrea Rütschle, more

Analytical and Bioanalytical Chemistry > 2015 > 407 > 9 > 2439-2453

Food-borne intoxications are increasingly caused by the dodecadepsipeptide cereulide, the emetic toxin produced by Bacillus cereus . As such intoxications pose a health risk to humans, a more detailed understanding on the chemodiversity of this toxin is mandatory for the reliable risk assessment of B. cereus toxins in foods. Mass spectrometric screening now shows a series...

article

The Correlation Between UCP Expression UND Cellular Metabolism

Anne Rupprecht, Dana Sittner, Alina Smorodchenko, Karolina E. Hilse, more

Biophysical Journal > 2014 > 106 > 2 Supplement 1 > 28a

article

Quantification of Mitochondrial UCP3 Expression in Mouse Tissues

Karolina E. Hilse, Anne Rupprecht, Anastasia Kalinovich, Irina G. Shabalina, more

Biophysical Journal > 2014 > 106 > 2 Supplement 1 > 592a

article

Purine Nucleotides Similarly Regulate Uncoupling Protein 3 and 1

Gabriel Pürstinger, Anne Rupprecht, Melanie Köhler, Peter Hinterdorfer, more

Biophysical Journal > 2014 > 106 > 2 Supplement 1 > 592a

article

Combined Single Molecule Recognition Imaging and Force Spectroscopy to Study the Interactions Between Uncoupling Proteins and Purine Nucleotides

Melanie Köhler, Gabriel Pürstinger, Rong Zhu, Anne Rupprecht, more

Biophysical Journal > 2014 > 106 > 2 Supplement 1 > 223a

article

Metabolic Regulation by the Mitochondrial Phosphatase PTPMT1 Is Required for Hematopoietic Stem Cell Differentiation

Wen-Mei Yu, Xia Liu, Jinhua Shen, Olga Jovanovic, more

Cell Stem Cell > 2013 > 12 > 1 > 62-74

The regulation and coordination of mitochondrial metabolism with hematopoietic stem cell (HSC) self-renewal and differentiation is not fully understood. Here we report that depletion of PTPMT1, a PTEN-like mitochondrial phosphatase, in inducible or hematopoietic-cell-specific knockout mice resulted in hematopoietic failure due to changes in the cell cycle and a block in the differentiation of HSCs...

article

Neural differentiation of mouse embryonic stem cells as a tool to assess developmental neurotoxicity in vitro

Anke Visan, Katrin Hayess, Dana Sittner, Elena E. Pohl, more

Neurotoxicology > 2012 > 33 > 5 > 1135-1146

Mouse embryonic stem cells (mESCs) represent an attractive cellular system for in vitro studies in developmental biology as well as toxicology because of their potential to differentiate into all fetal cell lineages. The present study aims to establish an in vitro system for developmental neurotoxicity testing employing mESCs. We developed a robust and reproducible protocol for fast and efficient...

article

Study of Nucleotide Binding to the Uncoupling Protein 1 using Atomic Force Microscopy

Rong Zhu, Anne Rupprecht, Andreas Ebner, Thomas Haselgrübler, more

Biophysical Journal > 2012 > 102 > 3 Supplement 1 > 607a

Publication date

Last year (1)
Last 3 years (1)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

INFONA - science communication portal

Search results for: Elena E. Pohl

The 2‐oxoglutarate/malate carrier extends the family of mitochondrial carriers capable of fatty acid and 2,4‐dinitrophenol‐activated proton transport

UCP2 up-regulation within the course of autoimmune encephalomyelitis correlates with T-lymphocyte activation

Protonation of Long Chain Fatty Acids at the Membrane-Water Interface

UCP2 regulation coincides with metabolic adaptation

Functions of UCP1 and UCP3 in brown adipose tissue – together or apart?

Structural, biological and biophysical properties of glycated and glycoxidized phosphatidylethanolamines

Binding Mechanism of Purine Nucleotides to Mitochondrial Uncoupling Proteins Explored by Recognition Force Spectroscopy

The expression of UCP3 directly correlates to UCP1 abundance in brown adipose tissue

The molecular mechanism behind reactive aldehyde action on transmembrane translocations of proton and potassium ions

Modified Aminophospholipids Strongly Alter the Function of Mitochondrial Membrane Protein UCP1

Effect of Reactive Aldehydes on Ionophore-Mediated Transmembrane Translocations of H+ and K+

Increased intracellular calcium level and impaired nutrient absorption are important pathogenicity traits in the chicken intestinal epithelium during Campylobacter jejuni colonization

Chemodiversity of cereulide, the emetic toxin of Bacillus cereus

The Correlation Between UCP Expression UND Cellular Metabolism

Quantification of Mitochondrial UCP3 Expression in Mouse Tissues

Purine Nucleotides Similarly Regulate Uncoupling Protein 3 and 1

Combined Single Molecule Recognition Imaging and Force Spectroscopy to Study the Interactions Between Uncoupling Proteins and Purine Nucleotides

Metabolic Regulation by the Mitochondrial Phosphatase PTPMT1 Is Required for Hematopoietic Stem Cell Differentiation

Neural differentiation of mouse embryonic stem cells as a tool to assess developmental neurotoxicity in vitro

Study of Nucleotide Binding to the Uncoupling Protein 1 using Atomic Force Microscopy

Filter options

Publication date

Content availability

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Elena E. Pohl

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options