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The serotonin 5-HT 1B receptors regulate the release of serotonin and are involved in various disease states, including depression and schizophrenia. The goal of the study was to evaluate a high affinity and high selectivity antagonist, [ 11 C]P943, as a positron emission tomography (PET) tracer for imaging the 5-HT 1B receptor. [ 11 C]P943 was synthesized via N-methylation...
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