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Mushroom poisonings occur when ingestion of wild mushrooms containing toxins takes place, placing the consumers at life-threatening risk. In the present case report, an unusual multiple poisoning with isoxazoles- and amatoxins-containing mushrooms in a context of altered mental state and poorly controlled hypertension is presented. A 68-year-old female was presented to São João hospital (Portugal)...
In the present study we show that phospholipases A 2 isolated from porcine pancreas (PP-PLA 2 ) and Crotalus durissus terrificus snake venom (SV-PLA 2 ) induced dose-dependent increases of LDH release from rabbit proximal tubules in suspension. Both porcine and crotalic PLA 2 s induced increases in non-esterified fatty acid (NEFA) levels (μg of NEFA/mg of tubule protein)...
The effect of Bothrops jararaca crude venom (BjV) on the cellular component of inflammatory responses was investigated in vivo and in vitro. In vivo leukocyte accumulation and release of eicosanoids (thromboxane A 2 , TXA 2 , and leukotriene B 4 , LTB 4 ) at the site of injection of the venom were assessed using the air pouch method in rats. Administration of BjV...
In the present study, the Bothrops jararaca venom (BjV)-induced inflammatory reaction in the rat air pouch was characterized in terms of vascular permeability, leukocyte influx and eicosanoid (PGE 2 , LTB 4 and TXB 2 ) release. Injection of crude BjV (10 μg/rat) into male Wistar rat air pouch induced a significant increase of vascular permeability during the first 30 min....
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