Search results for: Marc R. Dweck

Items from 1 to 20 out of 48 results

article

Non‐invasive imaging of functional pancreatic islet beta‐cell mass in people with type 1 diabetes mellitus

Shruti S. Joshi, Trisha Singh, Lucy E. Kershaw, Fraser W. Gibb, more

Aims To investigate whether manganese‐enhanced magnetic resonance imaging can assess functional pancreatic beta‐cell mass in people with type 1 diabetes mellitus. Methods In a prospective case–control study, 20 people with type 1 diabetes mellitus (10 with low (≥50 pmol/L) and 10 with very low (<50 pmol/L) C‐peptide concentrations) and 15 healthy volunteers underwent manganese‐enhanced magnetic...

article

PET‐MRI of Coronary Artery Disease

Beth Whittington, Marc R. Dweck, Edwin J.R. Beek, David Newby, more

Journal of Magnetic Resonance Imaging > 57 > 5 > 1301 - 1311

Simultaneous positron emission tomography and magnetic resonance imaging (PET‐MRI) combines the anatomical detail and tissue characterization of MRI with the functional information from PET. Within the coronary arteries, this hybrid technique can be used to identify biological activity combined with anatomically high‐risk plaque features to better understand the processes underlying coronary atherosclerosis...

article

Manganese‐Enhanced Magnetic Resonance Imaging of the Heart

Trisha Singh, Shruti Joshi, Lucy E Kershaw, Marc R Dweck, more

Journal of Magnetic Resonance Imaging > 57 > 4 > 1011 - 1028

Manganese‐based contrast media were the first in vivo paramagnetic agents to be used in magnetic resonance imaging (MRI). The uniqueness of manganese lies in its biological function as a calcium channel analog, thus behaving as an intracellular contrast agent. Manganese ions are taken up by voltage‐gated calcium channels in viable tissues, such as the liver, pancreas, kidneys, and heart, in response...

article

Off‐target effects of oral anticoagulants – vascular effects of vitamin K antagonist and non‐vitamin K antagonist oral anticoagulant dabigatran etexilate

Rick H. Gorp, Ingrid Dijkgraaf, Vanessa Bröker, Matthias Bauwens, more

Journal of Thrombosis and Haemostasis > 19 > 5 > 1348 - 1363

Introduction Vitamin K antagonists (VKA) and non‐vitamin K oral antagonist anticoagulants (NOAC) are used in the clinic to reduce risk of thrombosis. However, they also exhibit vascular off‐target effects. The aim of this study is to compare VKA and NOAC on atherosclerosis progression and calcification in an experimental setup. Material and methods Female Apoe^−/− mice (age 12 weeks) were fed Western‐type...

article

Triple-gated motion and blood pool clearance corrections improve reproducibility of coronary ¹⁸F-NaF PET

Martin Lyngby Lassen, Jacek Kwiecinski, Damini Dey, Sebastien Cadet, more

European Journal of Nuclear Medicine and Molecular Imaging > 2019 > 46 > 12 > 2610-2620

Purpose To improve the test–retest reproducibility of coronary plaque ¹⁸F-sodium fluoride (¹⁸F-NaF) positron emission tomography (PET) uptake measurements. Methods We recruited 20 patients with coronary artery disease who underwent repeated hybrid PET/CT angiography (CTA) imaging within 3 weeks. All patients had 30-min PET acquisition and CTA during a single imaging session. Five PET image-sets...

article

New methods to image unstable atherosclerotic plaques

Jack P.M. Andrews, Zahi A. Fayad, Marc R. Dweck

Atherosclerosis > 2018 > 272 > C > 118-128

Atherosclerotic plaque rupture is the primary mechanism responsible for myocardial infarction and stroke, the top two killers worldwide. Despite being potentially fatal, the ubiquitous prevalence of atherosclerosis amongst the middle aged and elderly renders individual events relatively rare. This makes the accurate prediction of MI and stroke challenging. Advances in imaging techniques now allow...

article

Wall Stress and Geometry of the Thoracic Aorta in Patients With Aortic Valve Disease

Barry J. Doyle, Paul E. Norman, Peter R. Hoskins, David E. Newby, more

The Annals of Thoracic Surgery > 2018 > 105 > 4 > 1077-1085

Aortic valve disease increases velocity and changes the way blood enters the aorta. Over time, the biomechanical environment can cause aortic remodelling. We hypothesized that aortic geometry and wall stress would be different in patients with aortic valve disease compared with controls.We examined 40 patients with aortic sclerosis (n = 10) or mild (n = 10), moderate (n = 10), and severe (n = 10)...

article

18F–Sodium Fluoride Uptake in Abdominal Aortic Aneurysms

Rachael O. Forsythe, Marc R. Dweck, Olivia M.B. McBride, Alex T. Vesey, more

Journal of the American College of Cardiology > 2018 > 71 > 5 > 513-523

Fluorine-18–sodium fluoride (¹⁸F-NaF) uptake is a marker of active vascular calcification associated with high-risk atherosclerotic plaque.In patients with abdominal aortic aneurysm (AAA), the authors assessed whether ¹⁸F-NaF positron emission tomography (PET) and computed tomography (CT) predicts AAA growth and clinical outcomes.In prospective case-control (n = 20 per group) and longitudinal cohort...

article

Hybrid Magnetic Resonance Imaging and Positron Emission Tomography With Fluorodeoxyglucose to Diagnose Active Cardiac Sarcoidosis

Marc R. Dweck, Ronan Abgral, Maria Giovanna Trivieri, Philip M. Robson, more

JACC: Cardiovascular Imaging > 2018 > 11 > 1 > 94-107

The purpose of this study was to explore the diagnostic usefulness of hybrid cardiac magnetic resonance (CMR) and positron emission tomography (PET) using ¹⁸F-fluorodeoxyglucose (FDG) for active cardiac sarcoidosis.Active cardiac sarcoidosis (aCS) is underdiagnosed and has a high mortality.Patients with clinical suspicion of aCS underwent hybrid CMR/PET with late gadolinium enhancement (LGE) and FDG...

article

Myocardial inflammation, injury and infarction during on-pump coronary artery bypass graft surgery

Shirjel R. Alam, Colin Stirrat, Nick Spath, Vipin Zamvar, more

Journal of Cardiothoracic Surgery > 2017 > 12 > 1 > 1-10

Background Myocardial inflammation and injury occur during coronary artery bypass graft (CABG) surgery. We aimed to characterise these processes during routine CABG surgery to inform the diagnosis of type 5 myocardial infarction. Methods We assessed 87 patients with stable coronary artery disease who underwent elective CABG surgery. Myocardial inflammation, injury and infarction were assessed using...

article

Myocardial Fibrosis and Cardiac Decompensation in Aortic Stenosis

Calvin W.L. Chin, Russell J. Everett, Jacek Kwiecinski, Alex T. Vesey, more

JACC: Cardiovascular Imaging > 2017 > 10 > 11 > 1320-1333

Cardiac magnetic resonance (CMR) was used to investigate the extracellular compartment and myocardial fibrosis in patients with aortic stenosis, as well as their association with other measures of left ventricular decompensation and mortality.Progressive myocardial fibrosis drives the transition from hypertrophy to heart failure in aortic stenosis. Diffuse fibrosis is associated with extracellular...

article

MR/PET Imaging of the Cardiovascular System

Philip M. Robson, Damini Dey, David E. Newby, Daniel Berman, more

JACC: Cardiovascular Imaging > 2017 > 10 > 10(PA) > 1165-1179

Cardiovascular imaging has largely focused on identifying structural, functional, and metabolic changes in the heart. The ability to reliably assess disease activity would have major potential clinical advantages, including the identification of early disease, differentiating active from stable conditions, and monitoring disease progression or response to therapy. Positron emission tomography (PET)...

article

Coronary Artery PET/MR Imaging

Philip M. Robson, Marc R. Dweck, Maria Giovanna Trivieri, Ronan Abgral, more

JACC: Cardiovascular Imaging > 2017 > 10 > 10(PA) > 1103-1112

The aims of this study were to describe the authors’ initial experience with combined coronary artery positron emission tomographic (PET) and magnetic resonance (MR) imaging using ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) and ¹⁸F-sodium fluoride (¹⁸F-NaF) radiotracers, describe common problems and their solutions, and demonstrate the feasibility of coronary PET/MR imaging in appropriate patients.Recently,...

article

End stage renal disease‐induced hypercalcemia may promote aortic valve calcification via Annexin VI enrichment of valve interstitial cell derived‐matrix vesicles

Lin Cui, Nabil A. Rashdan, Dongxing Zhu, Elspeth M. Milne, more

Journal of Cellular Physiology > 232 > 11 > 2985 - 2995

Patients with end‐stage renal disease (ESRD) have elevated circulating calcium (Ca) and phosphate (Pi), and exhibit accelerated progression of calcific aortic valve disease (CAVD). We hypothesized that matrix vesicles (MVs) initiate the calcification process in CAVD. Ca induced rat valve interstitial cells (VICs) calcification at 4.5 mM (16.4‐fold; p < 0.05) whereas Pi treatment alone had no effect...

article

Coronary Artery Calcification

Takehiro Nakahara, Marc R. Dweck, Navneet Narula, David Pisapia, more

JACC: Cardiovascular Imaging > 2017 > 10 > 5 > 582-593

Vascular calcification is a hallmark of atherosclerosis. The location, density, and confluence of calcification may change portions of the arterial conduit to a noncompliant structure. Calcifications may also seed the cap of a thin cap fibroatheroma, altering tensile forces on the cap and rendering the lesion prone to rupture. Many local and systemic factors participate in this process, including...

article

Clinical Utility of Combined FDG-PET/MR to Assess Myocardial Disease

Ronan Abgral, Marc R. Dweck, Maria Giovanna Trivieri, Philip M. Robson, more

JACC: Cardiovascular Imaging > 2017 > 10 > 5 > 594-597

article

Midwall Fibrosis and 5-Year Outcome in Moderate and Severe Aortic Stenosis

Vassilios S. Vassiliou, Aris Perperoglou, Claire E. Raphael, Sanjiv Joshi, more

Journal of the American College of Cardiology > 2017 > 69 > 13 > 1755-1756

article

99MTC-DURAMYCIN IMAGING DETECTS DOXORUBICIN CARDIAC INJURY BEFORE ONSET OF VENTRICULAR DYSFUNCTION

Takehiro Nakahara, Artiom D. Petrov, Takashi Tanimoto, Nezam Haider, more

Journal of the American College of Cardiology > 2017 > 69 > 11(S) > 1412

article

18F-Sodium Fluoride PET/MR for the Assessment of Cardiac Amyloidosis

Maria Giovanna Trivieri, Marc R. Dweck, Ronan Abgral, Philip M. Robson, more

Journal of the American College of Cardiology > 2016 > 68 > 24 > 2712-2714

article

Computed Tomography and Cardiac Magnetic Resonance in Ischemic Heart Disease

Marc R. Dweck, Michelle C. Williams, Alastair J. Moss, David E. Newby, more

Journal of the American College of Cardiology > 2016 > 68 > 20 > 2201-2216

Ischemic heart disease is a complex disease process caused by the development of coronary atherosclerosis, with downstream effects on the left ventricular myocardium. It is characterized by a long preclinical phase, abrupt development of myocardial infarction, and more chronic disease states such as stable angina and ischemic cardiomyopathy. Recent advances in computed tomography (CT) and cardiac...

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INFONA - science communication portal

Search results for: Marc R. Dweck

Non‐invasive imaging of functional pancreatic islet beta‐cell mass in people with type 1 diabetes mellitus

PET‐MRI of Coronary Artery Disease

Manganese‐Enhanced Magnetic Resonance Imaging of the Heart

Off‐target effects of oral anticoagulants – vascular effects of vitamin K antagonist and non‐vitamin K antagonist oral anticoagulant dabigatran etexilate

Triple-gated motion and blood pool clearance corrections improve reproducibility of coronary ¹⁸F-NaF PET

New methods to image unstable atherosclerotic plaques

Wall Stress and Geometry of the Thoracic Aorta in Patients With Aortic Valve Disease

18F–Sodium Fluoride Uptake in Abdominal Aortic Aneurysms

Hybrid Magnetic Resonance Imaging and Positron Emission Tomography With Fluorodeoxyglucose to Diagnose Active Cardiac Sarcoidosis

Myocardial inflammation, injury and infarction during on-pump coronary artery bypass graft surgery

Myocardial Fibrosis and Cardiac Decompensation in Aortic Stenosis

MR/PET Imaging of the Cardiovascular System

Coronary Artery PET/MR Imaging

End stage renal disease‐induced hypercalcemia may promote aortic valve calcification via Annexin VI enrichment of valve interstitial cell derived‐matrix vesicles

Coronary Artery Calcification

Clinical Utility of Combined FDG-PET/MR to Assess Myocardial Disease

Midwall Fibrosis and 5-Year Outcome in Moderate and Severe Aortic Stenosis

99MTC-DURAMYCIN IMAGING DETECTS DOXORUBICIN CARDIAC INJURY BEFORE ONSET OF VENTRICULAR DYSFUNCTION

18F-Sodium Fluoride PET/MR for the Assessment of Cardiac Amyloidosis

Computed Tomography and Cardiac Magnetic Resonance in Ischemic Heart Disease

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