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Quantitation of isoprostanes such as 8-iso-PGF 2α and 8,12-iso-iPF 2α -VI in biological fluids has been proposed as a reliable test of oxidant stress and inflammation in a variety of disorders. This paper presents a liquid chromatography method with tandem mass spectrometry detection for the simultaneous analysis of these two isoprostanes in human CSF and brain tissue samples. An API...
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