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We have previously reported that synthetic octacalcium phosphate (OCP) enhanced differentiation of osteoblasts and osteoclasts in vitro and also the bone regeneration in vivo. While the conversion of OCP into hydroxyapatite (HA) has been considered to be involved in the stimulatory capacity of OCP, little is known about the effect of topography of the OCP granule surface on its osteogenic capability...
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