Search results for: Wojciech Dyszkiewicz

Items from 1 to 20 out of 28 results

article

Serum lipidome screening in patients with stage I non-small cell lung cancer

Agnieszka Klupczynska, Szymon Plewa, Mariusz Kasprzyk, Wojciech Dyszkiewicz, more

Clinical and Experimental Medicine > 2019 > 19 > 4 > 505-513

The ability of early lung cancer diagnosis is an unmet need in clinical practice. Lung cancer metabolomic analyses conducted so far have demonstrated several abnormalities in cancer lipid profile providing a rationale for further study of blood lipidome of the patients. In the present research, we performed a targeted lipidome screening to select molecules that show promise for early lung cancer detection...

article

Analyzing Effectiveness of Routine Pleural Drainage After Nuss Procedure: A Randomized Study

Krystian Pawlak, Łukasz Gąsiorowski, Piotr Gabryel, Szymon Smoliński, more

The Annals of Thoracic Surgery > 2017 > 104 > 6 > 1852-1857

The routine use of postoperative pleural cavity drainage after the Nuss procedure is not widely accepted, and its limited use depends on experience. This study analyzed the influence of pleural drainage in the surgical treatment of patients with pectus excavatum on the prevention of pneumothorax and the efficacy of using drainage after a corrective operation.From November 2013 to May 2015, 103 consecutive...

article

Decreased expression of cytochrome p450 1B1 in non-small cell lung cancer

Bartosz Kazimierz Słowikowski, Bartłomiej Gałęcki, Wojciech Dyszkiewicz, Paweł Piotr Jagodziński

Biomedicine & Pharmacotherapy > 2017 > 95 > C > 339-345

Recent studies have associated oestrogen metabolism and cigarette smoking with their carcinogenic impact on the lungs. Compounds commonly found in tobacco smoke induce the activity of CYP1B1, the enzyme responsible for the synthesis of catecholic derivatives of oestrogens. During their redox transformations, these structures can release large amounts of reactive oxygen species or can form DNA adducts,...

article

Determination of 16 serum angiogenic factors in stage I non-small cell lung cancer using a bead-based multiplex immunoassay

Agnieszka Klupczynska, Paweł Dereziński, Jan Matysiak, Wojciech Dyszkiewicz, more

Biomedicine & Pharmacotherapy > 2017 > 88 > C > 1031-1037

The aim of the study was to identify significant abnormalities in angiogenic factor profiles occurring at early-stage non-small cell lung cancer (NSCLC). Contrary to the previous studies, our research included patients with only stage I NSCLC, which allowed for estimating the utility of circulating angiogenic factors in early NSCLC detection. The investigation was performed in serum samples collected...

article

Study of early stage non-small-cell lung cancer using Orbitrap-based global serum metabolomics

Agnieszka Klupczynska, Paweł Dereziński, Timothy J. Garrett, Vanessa Y. Rubio, more

Journal of Cancer Research and Clinical Oncology > 2017 > 143 > 4 > 649-659

Purpose The aim of the project was to apply ultra-high-performance liquid chromatography–quadrupole-Orbitrap-high-resolution mass spectrometry for serum metabolite profiling of non-small-cell lung cancer (NSCLC). This Orbitrap-based methodology has been applied for a study of NSCLC potential markers for the first time. Methods After extraction using protein precipitation, sera were separated on...

article

Early and Late Results of the Nuss Procedure in Surgical Treatment of Pectus Excavatum in Different Age Groups

Krystian Pawlak, Łukasz Gąsiorowski, Piotr Gabryel, Bartłomiej Gałęcki, more

The Annals of Thoracic Surgery > 2016 > 102 > 5 > 1711-1716

The aim of this study was a comparison of early and late results in surgical treatment of funnel chest using the Nuss method in patients in various age groups to find the optimal age to perform the corrective procedure.Six hundred eighty patients operated on from June 2002 to October 2012 were included in the retrospective analysis. Patients were divided into 3 different age groups: group A = 156...

article

Evaluation of serum amino acid profiles’ utility in non-small cell lung cancer detection in Polish population

Agnieszka Klupczynska, Paweł Dereziński, Wojciech Dyszkiewicz, Krystian Pawlak, more

Lung Cancer > 2016 > 100 > C > 71-76

Data from studies performed in Japanese and Korean populations suggest that free amino acid profiles have the potential to aid in non-small cell lung cancer (NSCLC) detection. However, there is still no data regarding abnormalities of free amino acids and their usefulness in NSCLC detection in European populations. The aim of the study was an evaluation of utility of amino acid profiles in NSCLC detection...

article

Determination of low-molecular-weight organic acids in non-small cell lung cancer with a new liquid chromatography–tandem mass spectrometry method

Agnieszka Klupczynska, Szymon Plewa, Wojciech Dyszkiewicz, Mariusz Kasprzyk, more

Journal of Pharmaceutical and Biomedical Analysis > 2016 > 129 > C > 299-309

As compared to other classes of metabolites, determination of organic acids is an underrepresented field in cancer research and till now there has been a lack of appropriate analytical procedure for determination of serum levels of organic acids potentially associated with cancer development. The aim of the study was to develop a new rapid liquid chromatography–tandem mass spectrometry method for...

article

Decreased expression of connective tissue growth factor in non-small cell lung cancer is associated with clinicopathological variables and can be restored by epigenetic modifiers

Hanna Drzewiecka, Bartłomiej Gałęcki, Donata Jarmołowska-Jurczyszyn, Andrzej Kluk, more

Journal of Cancer Research and Clinical Oncology > 2016 > 142 > 9 > 1927-1946

Purpose Recent studies indicated undisputed contribution of connective tissue growth factor (CTGF) in the development of many cancers, including non-small cell lung cancer (NSCLC). However, the functional role and regulation of CTGF expression during tumorigenesis remain elusive. Our goal was to determine CTGF transcript and protein levels in tumoral and matched control tissues from 98 NSCLC patients,...

article

Increased expression of proline-, glutamic acid- and leucine-rich protein PELP1 in non-small cell lung cancer

Bartosz Kazimierz Słowikowski, Bartłomiej Gałęcki, Wojciech Dyszkiewicz, Paweł Piotr Jagodziński

Biomedicine & Pharmacotherapy > 2015 > 73 > Complete > 97-101

It has been demonstrated that estrogens are able to enhance lung tumorigenesis by estrogen receptor (ER) pathway. ER signaling is a highly complex process that requires a number of different coactivators, including proline-, glutamic acid- and leucine-rich protein-1 (PELP1). We studied PELP1 transcript and protein levels in cancerous and histopathologically unchanged lung tissues obtained from 73...

article

Increased expression of 17-beta-hydroxysteroid dehydrogenase type 1 in non-small cell lung cancer

Hanna Drzewiecka, Bartłomiej Gałęcki, Donata Jarmołowska-Jurczyszyn, Andrzej Kluk, more

Lung Cancer > 2015 > 87 > 2 > 107-116

Recent studies indicated that estrogens may influence the development of non-small cell lung cancer (NSCLC). The 17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1) catalyzes the reduction of estrone (E1) to the highly potent E2. Although the significance of aromatase in an intratumoral E2 production in NSCLC is well established, the role of HSD17B1 remains largely unknown. Therefore, we investigated...

article

The efficacy of EGFR gene mutation testing in various samples from non-small cell lung cancer patients: a multicenter retrospective study

Paweł Krawczyk, Rodryg Ramlau, Joanna Chorostowska-Wynimko, Tomasz Powrózek, more

Journal of Cancer Research and Clinical Oncology > 2015 > 141 > 1 > 61-68

Introduction Testing for the epidermal growth factor receptor (EGFR) gene mutations requires considerable multidisciplinary experience of clinicians (for appropriate patient selection), pathologists (for selection of appropriate cytological or histological material) and geneticists (for performing and reporting reliable molecular tests). We present our experience on the efficacy of routine EGFR testing...

article

Correlation Between TS, MTHFR, and ERCC1 Gene Polymorphisms and the Efficacy of Platinum in Combination With Pemetrexed First-Line Chemotherapy in Mesothelioma Patients

Tomasz Powrózek, Dariusz M. Kowalski, Paweł Krawczyk, Rodryg Ramlau, more

Clinical Lung Cancer > 2014 > 15 > 6 > 455-465

The combination of pemetrexed and platinum compound represents the standard regimen for first-line chemotherapy in malignant pleural mesothelioma patients. Pemetrexed is a multitarget antifolate agent that inhibits folate-dependent enzymes (eg, thymidylate synthase [TS]) and thus synthesis of nucleotides and DNA. Expression of TS and folate availability, regulated by gene polymorphisms, have implications...

article

Polymorphisms in TS, MTHFR and ERCC1 genes as predictive markers in first-line platinum and pemetrexed therapy in NSCLC patients

Paweł Krawczyk, Tomasz Kucharczyk, Dariusz M. Kowalski, Tomasz Powrózek, more

Journal of Cancer Research and Clinical Oncology > 2014 > 140 > 12 > 2047-2057

Purpose We presented retrospective analysis of up to five polymorphisms in TS, MTHFR and ERCC1 genes as molecular predictive markers for homogeneous Caucasian, non-squamous NSCLC patients treated with pemetrexed and platinum front-line chemotherapy. Methods The following polymorphisms in DNA isolated from 115 patients were analyzed: various number of 28-bp tandem repeats in 5′-UTR region of TS...

article

A Piece of Glass in the Esophagus

Bartlomiej Galecki, Krystian Pawlak, Lukasz Gasiorowski, Wojciech Dyszkiewicz

The Annals of Thoracic Surgery > 2013 > 95 > 5 > 1806

article

An Effect of Nuss Procedure on Lung Function Among Patients with Pectus Excavatum

Sławomir Szydlik, Justyna Jankowska-Szydlik, Mariusz Kasprzyk, Wojciech Dyszkiewicz, more

Polish Journal of Surgery > 2013 > 85 > 1 > 1-5

The aim of the study<bold />was to evaluate lung function among patients who underwent Nuss Procedure. The analysis included spirometric evaluation of the lung function before Nuss Procedure, during perioperative period and after removing steel bars from behind the sternum. Material and methods.<bold />The study group involved patients operated on the pectus excavatum in the Department...

article

An Effect of Nuss Procedure on Lung Function Among Patients with Pectus Excavatum

Sławomir Szydlik, Justyna Jankowska-Szydlik, Mariusz Kasprzyk, Wojciech Dyszkiewicz, more

Comparative Professional Pedagogy > 2013 > 85 > 1 > 1-5

article

Life-Threatening Aortic Hemorrhage During Pectus Bar Removal

Marek Jemielity, Krystian Pawlak, Cezary Piwkowski, Wojciech Dyszkiewicz

The Annals of Thoracic Surgery > 2011 > 91 > 2 > 593-595

This report presents an unusual case of late, aortic hemorrhage that occurred during the removal of the stabilizing bar 3 years after a Nuss operation. The primary reason for this complication was a rotation of the sternum bar, which caused chronic damage to the aorta and development of an aortomediastinal fistula. Cardiopulmonary bypass and implantation of an aortic prosthesis were required for successful...

article

Can the condition of the cell microenvironment of mediastinal lymph nodes help predict the risk of metastases in non-small cell lung cancer?

Paweł Zieliński, Wojciech Dyszkiewicz, Cezary T. Piwkowski, Grzegorz Dworacki, more

Cancer Epidemiology > 2009 > 33 > 5 > 387-390

Background: The aim of this study was to analyze the properties of the immune cell microenvironment of regional lymph nodes (LNs) positive for lung cancer. Methods: Twenty-four patients operated on for stages T1 and T2 of the NSCLC, were enrolled in the study. Peripheral blood and LN tissue were obtained from different lymph node sites and levels. As a control, LN tissue was taken from patients diagnosed...

article

Reply to Apostolakis et al. Median sternotomy for combined coronary artery bypass grafting and lung tumor resection: is it valid or not?

Wojciech Dyszkiewicz, Cezary Piwkowski

European Journal of Cardio-Thoracic Surgery > 2009 > 35 > 6 > 1117-1118

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Search results for: Wojciech Dyszkiewicz

Serum lipidome screening in patients with stage I non-small cell lung cancer

Analyzing Effectiveness of Routine Pleural Drainage After Nuss Procedure: A Randomized Study

Decreased expression of cytochrome p450 1B1 in non-small cell lung cancer

Determination of 16 serum angiogenic factors in stage I non-small cell lung cancer using a bead-based multiplex immunoassay

Study of early stage non-small-cell lung cancer using Orbitrap-based global serum metabolomics

Early and Late Results of the Nuss Procedure in Surgical Treatment of Pectus Excavatum in Different Age Groups

Evaluation of serum amino acid profiles’ utility in non-small cell lung cancer detection in Polish population

Determination of low-molecular-weight organic acids in non-small cell lung cancer with a new liquid chromatography–tandem mass spectrometry method

Decreased expression of connective tissue growth factor in non-small cell lung cancer is associated with clinicopathological variables and can be restored by epigenetic modifiers

Increased expression of proline-, glutamic acid- and leucine-rich protein PELP1 in non-small cell lung cancer

Increased expression of 17-beta-hydroxysteroid dehydrogenase type 1 in non-small cell lung cancer

The efficacy of EGFR gene mutation testing in various samples from non-small cell lung cancer patients: a multicenter retrospective study

Correlation Between TS, MTHFR, and ERCC1 Gene Polymorphisms and the Efficacy of Platinum in Combination With Pemetrexed First-Line Chemotherapy in Mesothelioma Patients

Polymorphisms in TS, MTHFR and ERCC1 genes as predictive markers in first-line platinum and pemetrexed therapy in NSCLC patients

A Piece of Glass in the Esophagus

An Effect of Nuss Procedure on Lung Function Among Patients with Pectus Excavatum

An Effect of Nuss Procedure on Lung Function Among Patients with Pectus Excavatum

Life-Threatening Aortic Hemorrhage During Pectus Bar Removal

Can the condition of the cell microenvironment of mediastinal lymph nodes help predict the risk of metastases in non-small cell lung cancer?

Reply to Apostolakis et al. Median sternotomy for combined coronary artery bypass grafting and lung tumor resection: is it valid or not?

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