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Neurexins are presynaptic membrane cell-adhesion molecules which bind to neuroligins, a family of proteins that are associated with autism. To explore the possibility that structural variants in the neurexin α genes predispose to autism, the coding regions and associated splice junctions of the neurexin 1α gene were sequenced in 116 Caucasian patients with autism and 192 Caucasian controls. Five ultra-rare...
Neuroligins are postsynaptic membrane cell-adhesion molecules which bind to β-neurexins, a family of proteins that act as neuronal cell surface receptors. To explore the possibility that structural variants in the β-neurexin genes predispose to autism, the coding regions and associated splice junctions of three β-neurexin genes were scanned with detection of virtually all mutations-SSCP (DOVAM-S)...
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