Search results for: Caleb E. Finch

Items from 1 to 20 out of 92 results

article

Particulate matter exposure and chronic cerebral hypoperfusion promote oxidative stress and induce neuronal and oligodendrocyte apoptosis in male mice

Krista Lamorie‐Foote, Qinghai Liu, Kristina Shkirkova, Brandon Ge, more

Journal of Neuroscience Research > 101 > 3 > 384 - 402

Chronic cerebral hypoperfusion (CCH) may amplify the neurotoxicity of nanoscale particulate matter (nPM), resulting in white matter injury. This study characterized the joint effects of nPM (diameter ≤ 200 nm) and CCH secondary to bilateral carotid artery stenosis (BCAS) exposure on neuronal and white matter injury in a murine model. nPM was collected near a highway and re‐aerosolized for exposure...

article

The Oxygen Paradox, the French Paradox, and age-related diseases

Joanna M. S. Davies, Josiane Cillard, Bertrand Friguet, Enrique Cadenas, more

GeroScience > 2017 > 39 > 5-6 > 499-550

A paradox is a seemingly absurd or impossible concept, proposition, or theory that is often difficult to understand or explain, sometimes apparently self-contradictory, and yet ultimately correct or true. How is it possible, for example, that oxygen “a toxic environmental poison” could be also indispensable for life (Beckman and Ames Physiol Rev 78(2):547–81, 1998; Stadtman and Berlett Chem Res Toxicol...

article

Is coronary calcium scoring too late? Total body arterial calcium burden in patients without known CAD and normal MPI

Adel H. A. Allam, Randall C. Thompson, Michael A. Eskander, Mohamed A. Mandour Ali, more

Journal of Nuclear Cardiology > 2018 > 25 > 6 > 1990-1998

Background Patients with normal myocardial perfusion imaging (MPI) have a good prognosis. However, pre-clinical coronary and extracoronary atherosclerosis may exist in the absence of myocardial ischemia. Methods 154 Egyptian patients (mean age 53 years) underwent whole-body non-contrast CT following normal MPI. Results Atherosclerosis in the form of calcification was observed in ≥1 vascular bed...

article

Traffic-related air pollution impact on mouse brain accelerates myelin and neuritic aging changes with specificity for CA1 neurons

Nicholas C. Woodward, Payam Pakbin, Arian Saffari, Farimah Shirmohammadi, more

Neurobiology of Aging > 2017 > 53 > C > 48-58

Traffic-related air pollution (TRAP) is associated with lower cognition and reduced white matter volume in older adults, specifically for particulate matter <2.5-μm diameter (PM_2.5). Rodents exposed to TRAP have shown microglial activation and neuronal atrophy. We further investigated age differences of TRAP exposure, with focus on hippocampus for neuritic atrophy, white matter degeneration, and...

article

Coronary atherosclerosis in indigenous South American Tsimane: a cross-sectional cohort study

Hillard Kaplan, Randall C Thompson, Benjamin C Trumble, L Samuel Wann, more

The Lancet > 2017 > 389 > 10080 > 1730-1739

Conventional coronary artery disease risk factors might potentially explain at least 90% of the attributable risk of coronary artery disease. To better understand the association between the pre-industrial lifestyle and low prevalence of coronary artery disease risk factors, we examined the Tsimane, a Bolivian population living a subsistence lifestyle of hunting, gathering, fishing, and farming with...

article

Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo

Nicholas C. Woodward, Morgan C. Levine, Amin Haghani, Farimah Shirmohammadi, more

Journal of Neuroinflammation > 2017 > 14 > 1 > 1-15

Background Exposure to traffic-related air pollution (TRAP) is associated with accelerated cognitive aging and higher dementia risk in human populations. Rodent brains respond to TRAP with activation of astrocytes and microglia, increased inflammatory cytokines, and neurite atrophy. A role for Toll-like receptor 4 (TLR4) was suggested in mouse TLR4-knockouts, which had attenuated lung macrophage responses...

chapter

Early Life Conditions Affect Historical Change in Old-Age Mortality

Eileen M. Crimmins, Caleb E. Finch

Research and Perspectives in Longevity > Longevity and Frailty > 99-106

Summary Adult life expectancy has progressively increased over the past 150 years, equivalent to one year added per four years of historical time in high life-expectancy populations. This amazing decline of mortality at all adult ages is attributed to environmental and technological advances. Explanations of the decline in longter mortality typically are seated in terms of period or historical factors,...

article

Apolipoprotein E and Sex Bias in Cerebrovascular Aging of Men and Mice

Caleb E. Finch, Sara Shams

Trends in Neurosciences > 2016 > 39 > 9 > 625-637

Alzheimer disease (AD) research has mainly focused on neurodegenerative processes associated with the classic neuropathologic markers of senile plaques and neurofibrillary tangles. Additionally, cerebrovascular contributions to dementia are increasingly recognized, particularly from cerebral small vessel disease (SVD). Remarkably, in AD brains, the apolipoprotein E (ApoE) ɛ4 allele shows male excess...

chapter

The Long Thread of GFAP in Aging, Steroids, and Synaptic Plasticity

Caleb E. Finch, Todd E. Morgan, Irina Rozovsky, Min Wei

Research and Perspectives in Endocrine Interactions > Endocrine Aspects of Successful Aging: Genes, Hormones and Lifestyles > 191-206

Summary Glial fibrillary acidic protein (GFAP), an intermediate filament of astrocytes, shows progressive increases per cell during normal aging in the absence of neurodegenerative diseases. Increased transcription mediates the increase of GFAP expression. We hypothesize that increased GFAP expression is a factor in age-related impairments of synaptic plasticity, and we are developing an in vitro...

chapter

Estrogens, Aging, and Neurodegenerative Diseases

Caleb E. Finch, Todd Morgan, Irina Rozovsky

Research and Perspectives in Endocrine Interactions > Hormones and the Brain > 213-225

Summary Age is the greatest risk factor in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Indications of a female bias in AD and of a male bias in PD have been often discussed but are not definitive. Moreover, evidence that estrogen replacement may be beneficial for AD and PD is also controversial. An unevaluated factor is how aging and cumulative estrogen exposure may modify brain responses...

article

Eric Davidson's early years in development

Caleb E. Finch

Developmental Biology > 2016 > 412 > 2(S) > S3-S4

article

Urban traffic-derived nanoparticulate matter reduces neurite outgrowth via TNFα in vitro

Hank Cheng, David A. Davis, Sina Hasheminassab, Constantinos Sioutas, more

Journal of Neuroinflammation > 2016 > 13 > 1 > 1-11

Background The basis for air pollution-associated neurodegenerative changes in humans is being studied in rodent models. We and others find that the ultrafine particulate matter (PM) derived from vehicular exhaust can induce synaptic dysfunction and inflammatory responses in vivo and in vitro. In particular, a nano-sized subfraction of particulate matter (nPM, PM0.2) from a local urban traffic corridor...

article

The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice

Mafalda Cacciottolo, Amy Christensen, Alexandra Moser, Jiahui Liu, more

Neurobiology of Aging > 2016 > 37 > C > 47-57

The apolipoprotein APOE4 allele confers greater risk of Alzheimer's disease (AD) for women than men, in conjunction with greater clinical deficits per unit of AD neuropathology (plaques, tangles). Cerebral microbleeds, which contribute to cognitive dysfunctions during AD, also show APOE4 excess, but sex-APOE allele interactions are not described. We report that elderly men diagnosed for mild cognitive...

article

The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity

Fei Yin, Jia Yao, Harsh Sancheti, Tao Feng, more

Neurobiology of Aging > 2015 > 36 > 7 > 2282-2295

The perimenopause is an aging transition unique to the female that leads to reproductive senescence which can be characterized by multiple neurological symptoms. To better understand potential underlying mechanisms of neurological symptoms of perimenopause, the present study determined genomic, biochemical, brain metabolic, and electrophysiological transformations that occur during this transition...

article

The Tres Ventanas Mummies of Peru

L. Samuel Wann, Guido Lombardi, Bernadino Ojeda, Robert A. Benfer, more

The Anatomical Record > 298 > 6 > 1026 - 1035

The Tres Ventanas mummies of Peru are thought to be among the oldest mummies in existence, dating to between 8,000 and 10,000 years ago. A preliminary assessment is made of the potential of these mummies for use in future research on mummified remains. Although the Tres Ventanas cave and the four mummies were explored and then excavated by Frederic Engel in 1966–67, and the project is named in his...

article

The Orthopedic Diseases of Ancient Egypt

Klaus O Fritsch, Heshem Hamoud, Adel H. Allam, Alexander Grossmann, more

The Anatomical Record > 298 > 6 > 1036 - 1046

Background: CT scanning of ancient human remains has the potential to provide insights into health and diseases. While Egyptian mummies have undergone CT scans in prior studies, a systematic survey of the orthopedic conditions afflicting a group of these ancient individuals has never been carried out. Methods: We performed whole body CT scanning on 52 ancient Egyptian mummies using technique comparable...

article

Commentary: is Alzheimer's disease uniquely human?

Caleb E. Finch, Steven N. Austad

Neurobiology of Aging > 2015 > 36 > 2 > 553-555

That Alzheimer's disease (AD) might be a human-specific disease was hypothesized by Rapoport in 1989. Apes and humans share an identical amyloid beta (Aβ) peptide amino acid sequence and accumulate considerable Aβ deposits after age 40 years, an age when amyloid plaques are uncommon in humans. Despite their early Aβ buildup, ape brains have not shown evidence dystrophic neurites near plaques. Aging...

article

Corrigendum to “Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments”

Hongqiao Zhang, Honglei Liu, Kelvin J.A. Davies, Constantinos Sioutas, more

Free Radical Biology and Medicine > 2014 > 77 > Complete > 388

article

The menopause and aging, a comparative perspective

Caleb E. Finch

Journal of Steroid Biochemistry and Molecular Biology > 2014 > 142 > Complete > 132-141

The neuroendocrinology of menopause is reviewed from a comparative perspective, with emphasis on laboratory rodent models. These changes are compared by the 2011 STRAW criteria (Stages of Reproductive Aging Workshop). Ovarian cell loss begins prenatally in all mammals studied, with exponential depletion of primary follicles and oocytes in association with loss of fecundity by midlife. Rodents and...

article

Computed Tomographic Evidence of Atherosclerosis in the Mummified Remains of Humans From Around the World

Randall C. Thompson, Adel H. Allam, Albert Zink, L. Samuel Wann, more

Global Heart > 2014 > 9 > 2 > 187-196

Although atherosclerosis is widely thought to be a disease of modernity, computed tomographic evidence of atherosclerosis has been found in the bodies of a large number of mummies. This article reviews the findings of atherosclerotic calcifications in the remains of ancient people—humans who lived across a very wide span of human history and over most of the inhabited globe. These people had a wide...

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INFONA - science communication portal

Search results for: Caleb E. Finch

Particulate matter exposure and chronic cerebral hypoperfusion promote oxidative stress and induce neuronal and oligodendrocyte apoptosis in male mice

The Oxygen Paradox, the French Paradox, and age-related diseases

Is coronary calcium scoring too late? Total body arterial calcium burden in patients without known CAD and normal MPI

Traffic-related air pollution impact on mouse brain accelerates myelin and neuritic aging changes with specificity for CA1 neurons

Coronary atherosclerosis in indigenous South American Tsimane: a cross-sectional cohort study

Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo

Early Life Conditions Affect Historical Change in Old-Age Mortality

Apolipoprotein E and Sex Bias in Cerebrovascular Aging of Men and Mice

The Long Thread of GFAP in Aging, Steroids, and Synaptic Plasticity

Estrogens, Aging, and Neurodegenerative Diseases

Eric Davidson's early years in development

Urban traffic-derived nanoparticulate matter reduces neurite outgrowth via TNFα in vitro

The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice

The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity

The Tres Ventanas Mummies of Peru

The Orthopedic Diseases of Ancient Egypt

Commentary: is Alzheimer's disease uniquely human?

Corrigendum to “Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments”

The menopause and aging, a comparative perspective

Computed Tomographic Evidence of Atherosclerosis in the Mummified Remains of Humans From Around the World

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