Search results for: Marek Murias

Items from 1 to 20 out of 47 results

article

Antifungal, anticancer, and docking studies of colchiceine complexes with monovalent metal cation salts

Joanna Kurek, Patrycja Kwaśniewska‐Sip, Krzysztof Myszkowski, Grzegorz Cofta, more

Chemical Biology & Drug Design > 94 > 5 > 1930 - 1943

Complexes of colchiceine with monovalent cation perchlorates and iodides have been obtained and characterized by spectroscopic methods. DFT and spectroscopic studies reveal that the dihedral angle ω_{1‐1a‐12‐12a}, crucial for colchicine biological mechanism of action, that is, binding to tubulins depends on the diameter of the complexed metal cation. Biological tests indicated no antifungal properties...

article

The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines

Malgorzata Kucinska, Helena Mieszczak, Hanna Piotrowska-Kempisty, Mariusz Kaczmarek, more

Investigational New Drugs > 2019 > 37 > 5 > 849-864

Summary It has been shown previously that molecules built on benzanilide and thiobenzanilide scaffolds possess differential biological properties including selective anticancer activity. In our previous study, we examined the cytotoxic activity and mechanism of action of the thiobenzanilide derivative N,N′-(1,2-phenylene)bis3,4,5–trifluorobenzothioamide (63 T) as a potential chemotherapeutic compound...

article

Synthesis, in vitro and in silico evaluation of novel trans-stilbene analogues as potential COX-2 inhibitors

Miłosz Regulski, Hanna Piotrowska-Kempisty, Wiesław Prukała, Zbigniew Dutkiewicz, more

Bioorganic & Medicinal Chemistry > 2018 > 26 > 1 > 141-151

25 new trans-stilbene and trans-stilbazole derivatives were investigated using in vitro and in silico techniques. The selectivity and potency of the compounds were assessed using commercial ELISA test. The obtained results were incorporated into 2D QSAR assay. The most promising compound 4-nitro-3′,4′,5′-trihydroxy-trans-stilbene (N1) was synthetized and its potency and selectivity were confirmed...

article

EPR Oximetry Sensor—Developing a TAM Derivative for In Vivo Studies

Agnieszka Boś-Liedke, Magdalena Walawender, Anna Woźniak, Dorota Flak, more

Cell Biochemistry and Biophysics > 2018 > 76 > 1-2 > 19-28

Oxygenation is one of the most important physiological parameters of biological systems. Low oxygen concentration (hypoxia) is associated with various pathophysiological processes in different organs. Hypoxia is of special importance in tumor therapy, causing poor response to treatment. Triaryl methyl (TAM) derivative radicals are commonly used in electron paramagnetic resonance (EPR) as sensors for...

article

Antimicrobial and anticancer photodynamic activity of a phthalocyanine photosensitizer with N-methyl morpholiniumethoxy substituents in non-peripheral positions

Jolanta Dlugaszewska, Wojciech Szczolko, Tomasz Koczorowski, Paulina Skupin-Mrugalska, more

Journal of Inorganic Biochemistry > 2017 > 172 > C > 67-79

Photodynamic therapy involves the use of a photosensitizer that is irradiated with visible light in the presence of oxygen, resulting in the formation of reactive oxygen species. A novel phthalocyanine derivative, the quaternary iodide salt of magnesium(II) phthalocyanine with N-methyl morpholiniumethoxy substituents, was synthesized, and characterized. The techniques used included mass spectrometry...

article

Beyond mouse cancer models: Three-dimensional human-relevant in vitro and non-mammalian in vivo models for photodynamic therapy

Malgorzata Kucinska, Marek Murias, Patrycja Nowak-Sliwinska

Mutation Research/Reviews in Mutation Research > 2017 > 773 > C > 242-262

The proper design of experiments is a critical step for each study in order to obtain reproducible and reliable data. Taking into account constant competitiveness in the quickly developing biomedical sciences and the availability of sophisticated techniques, the choice and establishment of an experimental model system are essential for a successful research project. Currently, various sophisticated...

article

Role of CYP1A1 in the biological activity of methylated resveratrol analogue, 3,4,5,4′-tetramethoxystilbene (DMU-212) in ovarian cancer A-2780 and non-cancerous HOSE cells

Hanna Piotrowska-Kempisty, Agnieszka Klupczyńska, Dorota Trzybulska, Katarzyna Kulcenty, more

Toxicology Letters > 2017 > 267 > C > 59-66

The role of CYP1A1 and CYP1B1 enzymes in the biotransformation and biological activity of the methylated resveratrol analogue, 3,4,5,4′-tetramethoxystilbene (DMU-212) is still elusive. Our recently published data have shown that one of the metabolites of DMU-212, 3′-hydroxy-3,4,5,4′-tetramethoxystilbene (DMU-214) exerts more potent cytotoxic effects in A-2780 ovarian cancer cell line, as compared...

article

Selective anticancer activity of the novel thiobenzanilide 63T against human lung adenocarcinoma cells

Malgorzata Kucinska, Hanna Piotrowska-Kempisty, Natalia Lisiak, Mariusz Kaczmarek, more

Toxicology in Vitro > 2016 > 37 > C > 148-161

Previously, it has been reported that molecules built on the benzanilide and thiobenzanilide scaffold are the promising groups of compounds with several biological activities including antifungal, antimycotic, antibacterial, spasmolytic, and anticancer ones. In this study the mechanism of action of one selected thiobenzanilide derivative N,N′-(1,2-phenylene)bis3,4,5–trifluorobenzothioamide (63T) with...

article

The European Registered Toxicologist (ERT): Current status and prospects for advancement

Martin F. Wilks, Bas J. Blaauboer, Rolf Schulte-Hermann, Heather M. Wallace, more

Toxicology Letters > 2016 > 259 > C > 151-155

Following its inception in 1994, the certification of European Registered Toxicologists (ERT) by EUROTOX has been recognized as ensuring professional competence as well as scientific integrity and credibility. Criteria and procedures for registration are contained in the ERT “Guidelines for Registration 2012”. The register of ERT currently has over 1900 members.In order to continue the harmonisation...

article

COX-2 inhibitors: a novel strategy in the management of breast cancer

Miłosz Regulski, Katarzyna Regulska, Wiesław Prukała, Hanna Piotrowska, more

Drug Discovery Today > 2016 > 21 > 4 > 598-615

Cyclooxygenase-2 (COX-2) inhibitors are common anti-inflammatory drugs with pleiotropic, endogenous actions that could be useful in the management of breast cancer. Here, we provide a complete understanding of the biochemistry of COX-2 and discuss the various molecular mechanisms behind its increased expression in breast cancer. We also analyze the possible mechanisms responsible for the anticancer...

article

Core–shell fluorinated methacrylate nanoparticles with Rhodamine-B for confocal microscopy and fluorescence correlation spectroscopy applications

Maciej Jarzebski, Yingze Zhang, Tomasz Sliwa, Jarosław Mazuryk, more

Journal of Fluorine Chemistry > 2016 > 183 > C > 92-99

There is a need to develop nanosized and submicron sized stable and efficient fluorescent particles for confocal microscopy and fluorescence correlation spectroscopy, which are useful methods to study dynamics and interactions in complex colloidal systems and living cells. Fluorescent core–transparent shell fluorinated polymer nanoparticles exhibit low refractive index, close to that of water, high...

article

Synthesis and characterization of SBA-16 type mesoporous materials containing amine groups

Agnieszka Feliczak-Guzik, Barbara Jadach, Hanna Piotrowska, Marek Murias, more

Microporous and Mesoporous Materials > 2016 > 220 > C > 231-238

This work describes the synthesis of SBA-16 modified with amine groups and chitosan. The synthesized materials were characterized by small angle XRD (SXRD), wide angle XRD (WXRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Fourier-transformed Infra-red (FTIR) spectroscopy and nitrogen adsorption/desorption techniques. The characterization results revealed that the...

article

Erratum to: Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,3′-diindolymethane in human breast epithelial cell lines

Barbara E. Licznerska, Hanna Szaefer, Marek Murias, Agnieszka Bartoszek, more

European Journal of Nutrition > 2016 > 55 > 3 > 1315-1316

article

Triterpenoid saponins and C-glycosyl flavones from stem bark of Erythrina abyssinica Lam and their cytotoxic effects.

Andy J. Pérez, Emad M. Hassan, Łukasz Pecio, Elsayed A. Omer, more

Phytochemistry Letters > 2015 > 13 > Complete > 59-67

Six new compounds including two oleanane-type triterpenoid saponins (1, 2) and four C-glycosyl flavones (3–6), along with a known saponin (7), three di-C-glycosyl flavones (8–10) and a glycosyl auronol (11), were isolated from the stem bark of Erythrina abyssinica Lam. The structures of the new compounds, identified as 3-O-[α-l-rhamnopyranosyl-(1→2)-β-d-galactopyranosyl-(1→2)-β-d-glucuronopyranosyl]-22-O-β-d-glucopyranosyl...

article

Characterization of new eye drops with choline salicylate and assessment of their irritancy by in vitro short time exposure tests

Katarzyna Wroblewska, Małgorzata Kucinska, Marek Murias, Janina Lulek

Saudi Pharmaceutical Journal > 2015 > 23 > 4 > 407-412

The aim of our study was to examine the irritation potential of new eye drops containing 2% choline salicylate (CS) as an active pharmaceutical ingredient (API) and various polymers increasing eye drop viscosity (hydroxyethylcellulose, hydroxypropyl methylcellulose, methylcellulose, polyvinyl alcohol, polyvinylpyrrolidone). The standard method for assessing the potential of irritating substances has...

article

Photophysical properties and photochemistry of a sulfanyl porphyrazine bearing isophthaloxybutyl substituents

Sebastian Lijewski, Mateusz Gierszewski, Lukasz Sobotta, Jaroslaw Piskorz, more

Dyes and Pigments > 2015 > 113 > Complete > 702-708

A magnesium porphyrazine possessing isophthaloxybutylsulfanyl substituents in the periphery was synthesized and subjected to various photophysical studies, including optical absorption and emission measurements. Moreover, synchronous fluorescence spectra were recorded and a contour three-dimensional map of the excitation-emission of the studied porphyrazine was obtained. The porphyrazine macrocycle...

article

Modulating Potential of L‐Sulforaphane in the Expression of Cytochrome P450 to Identify Potential Targets for Breast Cancer Chemoprevention and Therapy Using Breast Cell Lines

Barbara Licznerska, Hanna Szaefer, Iwona Matuszak, Marek Murias, more

Phytotherapy Research > 29 > 1 > 93 - 99

The L‐sulforaphane (SFN) component of broccoli sprout showed anticancer activity in several preclinical studies including breast cancer. Estrogens are considered major risk factors in breast carcinogenesis. The aim of this study was to evaluate the effect of SFN on the expression of cytochrome P450 involved in the estrogen metabolism in breast cancer cell lines MCF7 and MDA‐MB‐231 and in non‐tumorigenic...

article

The mutagenicity analysis of imidapril hydrochloride and its degradant, diketopiperazine derivative, nitrosation mixtures by in vitro Ames test with two strains of Salmonella typhimurium

Katarzyna Regulska, Marek Murias, Beata Stanisz, Miłosz Regulski

Reports of Practical Oncology & Radiotherapy > 2014 > 19 > 6 > 412-419

The evaluation of mutagenic properties of imidapril hydrochloride (IMD) and its degradation impurity, diketopiperazine derivative (DKP), nitrosation mixtures was conducted in order to analyze the carcinogenic risk of IMD long-term treatment in patients. In this study an in vitro Ames test with Salmonella enterica serovar Typhimurium TA 98 and TA 100 strains was used.IMD and DKP contain nitrogen atoms,...

article

How to design a potent, specific, and stable angiotensin-converting enzyme inhibitor

Katarzyna Regulska, Beata Stanisz, Miłosz Regulski, Marek Murias

Drug Discovery Today > 2014 > 19 > 11 > 1731-1743

Angiotensin-converting enzyme inhibitors (ACE-Is) are a valuable class of antihypertensive drugs used in the treatment of cardiovascular system-related diseases. Hence, constant research into, and the development of, such compounds remain within the priorities of modern medical sciences. In this respect, a thorough understanding of their chemistry and biology is an important aspect of drug design;...

article

DMU-212 inhibits tumor growth in xenograft model of human ovarian cancer

Hanna Piotrowska, Krzysztof Myszkowski, Joanna Abraszek, Eliza Kwiatkowska-Borowczyk, more

Biomedicine & Pharmacotherapy > 2014 > 68 > 4 > 397-400

DMU-212 has been shown to evoke a mitochondrial apoptotic pathway in transformed fibroblasts and breast cancer. However, recently published data indicated the ability of DMU-212 to evoke apoptosis in both mitochondria- and receptor-mediated manner in two ovarian cancer cell lines, namely A-2780 and SKOV-3, which showed varied sensitivity to the compound tested. The pronounced cytotoxic effects of...

Publication date

Set your own date range

INFONA - science communication portal

Search results for: Marek Murias

Antifungal, anticancer, and docking studies of colchiceine complexes with monovalent metal cation salts

The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines

Synthesis, in vitro and in silico evaluation of novel trans-stilbene analogues as potential COX-2 inhibitors

EPR Oximetry Sensor—Developing a TAM Derivative for In Vivo Studies

Antimicrobial and anticancer photodynamic activity of a phthalocyanine photosensitizer with N-methyl morpholiniumethoxy substituents in non-peripheral positions

Beyond mouse cancer models: Three-dimensional human-relevant in vitro and non-mammalian in vivo models for photodynamic therapy

Role of CYP1A1 in the biological activity of methylated resveratrol analogue, 3,4,5,4′-tetramethoxystilbene (DMU-212) in ovarian cancer A-2780 and non-cancerous HOSE cells

Selective anticancer activity of the novel thiobenzanilide 63T against human lung adenocarcinoma cells

The European Registered Toxicologist (ERT): Current status and prospects for advancement

COX-2 inhibitors: a novel strategy in the management of breast cancer

Core–shell fluorinated methacrylate nanoparticles with Rhodamine-B for confocal microscopy and fluorescence correlation spectroscopy applications

Synthesis and characterization of SBA-16 type mesoporous materials containing amine groups

Erratum to: Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,3′-diindolymethane in human breast epithelial cell lines

Triterpenoid saponins and C-glycosyl flavones from stem bark of Erythrina abyssinica Lam and their cytotoxic effects.

Characterization of new eye drops with choline salicylate and assessment of their irritancy by in vitro short time exposure tests

Photophysical properties and photochemistry of a sulfanyl porphyrazine bearing isophthaloxybutyl substituents

Modulating Potential of L‐Sulforaphane in the Expression of Cytochrome P450 to Identify Potential Targets for Breast Cancer Chemoprevention and Therapy Using Breast Cell Lines

The mutagenicity analysis of imidapril hydrochloride and its degradant, diketopiperazine derivative, nitrosation mixtures by in vitro Ames test with two strains of Salmonella typhimurium

How to design a potent, specific, and stable angiotensin-converting enzyme inhibitor

DMU-212 inhibits tumor growth in xenograft model of human ovarian cancer

Filter options

Publication date

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Marek Murias

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options