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Noradrenaline-stimulated phosphoinositide breakdown in cultured glia was found to be mediated by α 1A -adrenoceptors. The α 1A -selective agonist A61603 was as effective as noradrenaline in eliciting 3 H-inositol phosphate (IP) accumulation but was approximately 50-fold more potent. In addition, the use of selective antagonists revealed a clear rank order of potency...
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