Search results for: Dominique Rigal

Items from 1 to 20 out of 37 results

article

CD8⁺ T cells mediate ultraviolet A‐induced immunomodulation in a model of extracorporeal photochemotherapy

Olivier Hequet, Audrey Nosbaum, Aurélie Guironnet‐Paquet, Elisabeth Blasco, more

European Journal of Immunology > 50 > 5 > 725 - 735

Extracorporeal photochemotherapy (ECP) that takes advantage of the immunomodulatory effects of UV light has been extensively used for many years for the treatment of several T cell–mediated diseases, including graft‐versus‐host disease (GvHD) and systemic scleroderma. Immune mechanisms that lead to the establishment of T cell tolerance in ECP‐treated patients remain poorly known. In this study, we...

article

A multicenter validation of recombinant β3 integrin–coupled beads to detect human platelet antigen‐1 alloantibodies in 498 cases of fetomaternal alloimmune thrombocytopenia

Winnie Chong, Ernest Turro, Paul Metcalfe, Rizwan Yusuf, more

Transfusion > 55 > 11 > 2742 - 2751

BACKGROUNDFetomaternal alloimmune thrombocytopenia (FMAIT) is caused by human platelet (PLT) antigen (HPA) incompatibility. Beads coupled with recombinant β3 integrins, displaying the biallelic HPA‐1 epitopes (rHPA‐1), have been shown to detect HPA‐1a alloantibodies implicated in FMAIT. This report describes a multicenter validation of the beads using the results of well‐characterized samples to define...

article

Flexible Automated Platform for Blood Group Genotyping on DNA Microarrays

Sandra Paris, Dominique Rigal, Valérie Barlet, Martine Verdier, more

The Journal of Molecular Diagnostics > 2014 > 16 > 3 > 335-342

The poor suitability of standard hemagglutination–based assay techniques for large-scale automated screening of red blood cell antigens severely limits the ability of blood banks to supply extensively phenotype-matched blood. With better understanding of the molecular basis of blood antigens, it is now possible to predict blood group phenotype by identifying single-nucleotide polymorphisms in genomic...

article

Does high-resolution donor typing of HLA-C or other loci upon registration confer advantages to patients?

Valerie Dubois, Catherine Giannoli, Marie Lorraine Balère, Sylvie Rey, more

Human Immunology > 2011 > 72 > 11 > 1033-1038

Our study compared all requests for confirmatory typing (CT requests) received in our center between May 2007 and December 2009 (n = 134) for donors issued from 3 groups defined by different human leukocyte antigen (HLA) loci typed at different levels of resolution. We observed a significant advantage for volunteers when HLA-C 2-digit typing was available or with HLA-A, -B, -C, -DRB1 4-digit typing...

article

l‐asparaginase loaded red blood cells in refractory or relapsing acute lymphoblastic leukaemia in children and adults: results of the GRASPALL 2005‐01 randomized trial

Carine Domenech, Xavier Thomas, Sylvie Chabaud, Andre Baruchel, more

British Journal of Haematology > 153 > 1 > 58 - 65

l‐asparaginase encapsulated within erythrocytes (GRASPA^®) should allow serum asparagine depletion over a longer period than the native form of the enzyme, using lower doses and allowing better tolerance. The GRASPALL 2005‐01 study, a multicentre randomized controlled trial, investigated three doses of GRASPA^® for the duration of asparagine depletion in a phase I/II study in adults and children with...

article

Quantitative and functional analyses of CD4⁺CD25⁺FoxP3⁺ regulatory T cells in chronic phase chronic myeloid leukaemia patients at diagnosis and on imatinib mesylate

Emmanuel Bachy, Janine Bernaud, Pascal Roy, Dominique Rigal, more

British Journal of Haematology > 153 > 1 > 139 - 143

article

Multipurpose high-throughput filtering microarrays (HiFi) for DNA and protein assays

Gaelle C. Le Goff, Cloé Desmet, Jean-Charles Brès, Dominique Rigal, more

Biosensors and Bioelectronics > 2010 > 26 > 4 > 1142-1151

We are reporting here a low cost colorimetric device for high-throughput multiplexed blood group genotyping and allergy diagnosis, displayed as an automated 96-well microtiter plate format. A porous polymeric membrane sealed at the bottom of each well accounts for the sensor support. For each sensing unit, a 6×6 matrix of specific probes is spotted on the external surface of the membrane resulting...

article

Robust, High-Throughput Solution for Blood Group Genotyping

Gaelle C. Le Goff, Jean-Charles Brès, Dominique Rigal, Loïc J. Blum, more

Analytical Chemistry > 2010 > 82 > 14 > 6185 - 6192

article

Inositol hexaphosphate–loaded red blood cells prevent in vitro sickling

Vanessa Bourgeaux, Olivier Hequet, Yannick Campion, Gaëlle Delcambre, more

Transfusion > 50 > 10 > 2176 - 2184

BACKGROUND: Hypoxia is a major cause of painful vaso‐occlusive crisis in sickle cell disease (SCD). Simple transfusion and red blood cell (RBC) exchange are commonly used as preventive therapies whose aim is to dilute hemoglobin (Hb)S‐containing RBCs (SS‐RBCs) with normal RBCs (AA‐RBCs) to prevent sickling. We hypothesized that the effectiveness of transfusion could be improved by the encapsulation...

article

Development of miniaturized immunoassay: Influence of surface chemistry and comparison with enzyme-linked immunosorbent assay and Western blot

Graziella El Khoury, Emmanuelle Laurenceau, Yann Chevolot, Yves Mérieux, more

Analytical Biochemistry > 2010 > 400 > 1 > 10-18

Protein microarray technology provides a useful approach for the simultaneous serodetection of various antibodies in low sample volumes. To implement functional protein microarrays, appropriate surface chemistry must be designed so that both the protein structure and the biological activity can be retained. In the current study, two surface chemistries for protein microarrays and immunofluorescent...

article

La recherche des anticorps anti-plaquettes spécifiques : deux tests de dépistage sont-ils nécessaires ?

Pierre Moncharmont, Sylvie Canillas, Martine Vignal, Yves Mérieux, more

Revue Francophone des Laboratoires > 2009 > 2009 > 412 > 49-51

De nombreuses techniques sont disponibles pour le dépistage et l’identification des anticorps (Acs) anti-plaquettes (PLT) spécifiques, mais l’efficacité de certaines demeure controversée. Pour l’apprécier, deux méthodes ont été évaluées simultanément en dépistage, l’immunocapture (IC) et le « monoclonal antibody-specific immobilization of platelet antigen » (MAIPA). Parmi 737 échantillons, 95 (12,9...

article

Induction of high expression of CCR7 and high production of IL-12 in human monocyte-derived dendritic cells by a new bacterial component: LCOS 1013

Stéphanie Gillet-Hladky, Karine Duperrier, Stéphanie Picandet, Virginie Mathias, more

International Immunopharmacology > 2008 > 8 > 9 > 1151-1163

Dendritic cells (DCs) are the most potent antigen presenting cells of the immune system as they can act as initiators, stimulators and regulators of the immune response. Human DCs are most commonly generated for clinical use by in vitro differentiation of monocytes with exogenous cytokines. Here, we investigate the effect of LCOS 1013 on the production of mature Mo-DCs. LCOS 1013 is a new bacterial...

article

Les allo-immunisations fœto-maternelles anti-érythrocytaires : état de l’art en 2008

Dominique Rigal, Francis Meyer, Elisabeth Mayrand, Françoise Dupraz

Revue Francophone des Laboratoires > 2008 > 2008 > 402 > 51-62

En 2008, les allo-immunisations fœto-maternelles anti-érythrocytaires restent d’actualité du fait de leur persistance et surtout de part les modalités de prise en charge qui ont été largement bouleversées par trois progrès très substantiels. Ce sont d’une part, par la découverte de tous les gènes qui codent pour les groupes sanguins érythrocytaires qui permet de déterminer dans le plasma maternel...

article

Analysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients

Wen-Hui Cao, Xiaogan Wang, Lucien Frappart, Dominique Rigal, more

Mutation Research - Genetic Toxicology and Environmental Mutagenesis > 2007 > 632 > 1-2 > 20-28

Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that catalyzes the poly(ADP-ribosyl)ation of target proteins in response to DNA damage and has been proposed to play a role in DNA repair, recombination, transcription, cell death, cell proliferation, as well as in stabilization of the genome. We have recently shown that PARP-1 deficiency causes mammary tumorigenesis in mice. In the present...

article

Toll-like receptor 3 (TLR3): A new marker of canine monocytes-derived dendritic cells (cMo-DC)

Catherine Bonnefont-Rebeix, Thierry Marchal, Janine Bernaud, Jean-Jacques Pin, more

Veterinary Immunology and Immunopathology > 2007 > 118 > 1-2 > 134-139

Toll-like receptors (TLRs) are a family of functionally important receptors for recognition of pathogen-associated molecular pattern (PAMP) since they trigger the pro-inflammatory response and upregulation of costimulatory molecules, linking the rapid innate response to adaptative immunity. In human leukocytes, TLR3 has been found to be specifically expressed in dendritic cells (DC). This study examined...

article

Minor Histocompatibility Antigen DDX3Y Induces HLA-DQ5-Restricted T Cell Responses with Limited TCR-Vβ Usage Both In Vivo and In Vitro

David Laurin, Eric Spierings, Lars T. van der Veken, Abdelbasset Hamrouni, more

Biology of Blood and Marrow Transplantation > 2006 > 12 > 11 > 1114-1124

In vitro stimulation of human female T cells with male HLA-identical dendritic cells resulted in the generation of HLA-DQB1*0501/0502-restricted minor histocompatibility H-Y antigen-specific CD4 ⁺ T cell clones. Two clones generated from different HLA-identical pairs were analyzed. Use of HLA-DQ5-expressing female Epstein-Barr virus transformed B lymphoblastoid cell lines transfected with...

article

Amélioration d'une technique de dépistage de l'hémoglobinurie paroxystique nocturne en cytométrie en flux

Pierre Moncharmont, Janine Bernaud, Annick Raffin, Dominique Rigal

Revue Francophone des Laboratoires > 2006 > 2006 > 386 > 41-44

L'hémoglobinurie paroxystique nocturne (HPN) se traduit par un déficit d'une ou plusieurs des protéines régulatrices du complément sur les érythrocytes favorisant l'hémolyse. Le test au sucrose et l'étude en cytométrie en flux de 3 marqueurs, les CD55, CD58 et CD59 ont été employés pour détecter un clone déficitaire. Afin d'optimiser cette recherche, une technique avec lavages automatisés des érythrocytes...

article

CD86 molecule is a specific marker for canine monocyte-derived dendritic cells

Catherine Bonnefont-Rebeix, Camila Miranda de Carvalho, Janine Bernaud, Luc Chabanne, more

Veterinary Immunology and Immunopathology > 2006 > 109 > 1-2 > 167-176

In this study, canine monocyte-derived dendritic cells (cMo-DC) were produced in presence of canine GM-CSF (cGM-CSF) and canine IL-4 (cIL-4), and they were characterized by their dendritic morphology, MLR functionality and phenotype. We noticed that cMo-DC were labelled with three anti-human CD86 (FUN-1, BU63 and IT2.2 clones), whereas resting and activated lymphocytes or monocytes were not stained...

article

Erratum to “Evaluation of elutriation and magnetic microbead purification of canine monocytes” [Vet. Immunol. Immunopathol. 101(2004) 171–178]

Camila Miranda de Carvalho, Catherine Bonnefont-Rebeix, Stephanie Picandet, Janine Bernaud, more

Veterinary Immunology and Immunopathology > 2005 > 104 > 3-4 > 297

article

Control of P-Glycoprotein Activity by Membrane Cholesterol Amounts and Their Relation to Multidrug Resistance in Human CEM Leukemia Cells ^†

Landry Gayet, Guila Dayan, Stéphane Barakat, Stéphane Labialle, more

Biochemistry > 2005 > 44 > 11 > 4499 - 4509

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Search results for: Dominique Rigal

CD8⁺ T cells mediate ultraviolet A‐induced immunomodulation in a model of extracorporeal photochemotherapy

A multicenter validation of recombinant β3 integrin–coupled beads to detect human platelet antigen‐1 alloantibodies in 498 cases of fetomaternal alloimmune thrombocytopenia

Flexible Automated Platform for Blood Group Genotyping on DNA Microarrays

Does high-resolution donor typing of HLA-C or other loci upon registration confer advantages to patients?

l‐asparaginase loaded red blood cells in refractory or relapsing acute lymphoblastic leukaemia in children and adults: results of the GRASPALL 2005‐01 randomized trial

Quantitative and functional analyses of CD4⁺CD25⁺FoxP3⁺ regulatory T cells in chronic phase chronic myeloid leukaemia patients at diagnosis and on imatinib mesylate

Multipurpose high-throughput filtering microarrays (HiFi) for DNA and protein assays

Robust, High-Throughput Solution for Blood Group Genotyping

Inositol hexaphosphate–loaded red blood cells prevent in vitro sickling

Development of miniaturized immunoassay: Influence of surface chemistry and comparison with enzyme-linked immunosorbent assay and Western blot

La recherche des anticorps anti-plaquettes spécifiques : deux tests de dépistage sont-ils nécessaires ?

Induction of high expression of CCR7 and high production of IL-12 in human monocyte-derived dendritic cells by a new bacterial component: LCOS 1013

Les allo-immunisations fœto-maternelles anti-érythrocytaires : état de l’art en 2008

Analysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients

Toll-like receptor 3 (TLR3): A new marker of canine monocytes-derived dendritic cells (cMo-DC)

Minor Histocompatibility Antigen DDX3Y Induces HLA-DQ5-Restricted T Cell Responses with Limited TCR-Vβ Usage Both In Vivo and In Vitro

Amélioration d'une technique de dépistage de l'hémoglobinurie paroxystique nocturne en cytométrie en flux

CD86 molecule is a specific marker for canine monocyte-derived dendritic cells

Erratum to “Evaluation of elutriation and magnetic microbead purification of canine monocytes” [Vet. Immunol. Immunopathol. 101(2004) 171–178]

Control of P-Glycoprotein Activity by Membrane Cholesterol Amounts and Their Relation to Multidrug Resistance in Human CEM Leukemia Cells ^†

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