Search results for: Kiichiro Nakajima

Items from 1 to 12 out of 12 results

article

The acceleration of boron neutron capture therapy using multi-linked mercaptoundecahydrododecaborate (BSH) fused cell-penetrating peptide

Hiroyuki Michiue, Yoshinori Sakurai, Natsuko Kondo, Mizuki Kitamatsu, more

Biomaterials > 2014 > 35 > 10 > 3396-3405

New anti-cancer therapy with boron neutron capture therapy (BNCT) is based on the nuclear reaction of boron-10 with neutron irradiation. The median survival of BNCT patients with glioblastoma was almost twice as long as those receiving standard therapy in a Japanese BNCT clinical trial. In this clinical trial, two boron compounds, BPA (boronophenylalanine) and BSH (sodium borocaptate), were used for...

article

The impact of extracellular syntaxin4 on HaCaT keratinocyte behavior

Nanako Kadono, Takafumi Miyazaki, Yoji Okugawa, Kiichiro Nakajima, more

Biochemical and Biophysical Research Communications > 2012 > 417 > 4 > 1200-1205

Syntaxin4 belongs to t-SNARE protein family and functions as a vesicular fusion mediator in the plasma membrane in a wide variety of cell types. This protein resembles another family member, epimorphin, a subpopulation of which has been shown to be secreted extracellularly in order to exert signaling functions. Here, we demonstrate the secretion of syntaxin4 via a non-classical pathway and its extracellular...

article

Organic near‐infrared photodiodes containing a wide‐bandgap polymer and an n‐type dopant in the active layer

Naoki Ohtani, Kiichiro Nakajima, Ken‐ichi Bando

physica status solidi c > 8 > 9 > 2907 - 2910

In this research, organic photodiodes (NIR‐OPDs) operating in the near‐infrared region were fabricated by wet process. Copper(II) 5,9,14,18,23,27,32,36‐octabutoxy‐2,3‐naphthalocyanine (Cu(II)) was used as a photovoltaic material in the active layer, whose λmax is in the NIR region. To improve the dark current property and external quantum efficiency (EQE), a wide‐bandgap polymer and an n‐type dopant...

article

Immunocytochemical localization of adrenomedullin 2/intermedin-like immunoreactivity in human hypothalamus, heart and kidney

Kazuhiro Takahashi, Kumi Kikuchi, Yutaka Maruyama, Tomoko Urabe, more

Peptides > 2006 > 27 > 6 > 1383-1389

Adrenomedullin 2/intermedin (AM2/IMD) is a novel member of the calcitonin/calcitonin gene-related peptide (CGRP) peptide family. AM2/IMD has a vasodilator action, and antidiuretic and antinatriuretic effects in mice. The aim of the present study is to clarify immunolocalization of AM2/IMD in human hypothalamus, heart and kidney obtained at autopsy. Immunocytochemistry showed AM2/IMD-immunoreactive...

article

Site-Dependent Effect of O-Glycosylation on the Conformation and Biological Activity of Calcitonin ^†

Mizuka Tagashira, Hideki Iijima, Yukihiro Isogai, Masayuki Hori, more

Biochemistry > 2001 > 40 > 37 > 11090 - 11095

article

Primary Structure and Bioactivity of Bullfrog Calcitonin

Azusa Yoshida, Hiroyuki Kaiya, Yoshio Takei, Takushi X. Watanabe, more

General and Comparative Endocrinology > 1997 > 107 > 2 > 147-152

Calcitonin was isolated from the bullfrog,Rana catesbeiana,and the first amino acid sequence of an amphibian calcitonin was determined to be Cys-Ser-Gly-Leu-Ser-Thr-Cys-Ala-Leu-Met-Lys-Leu-Ser-Gln-Asp-Leu-His-Arg-Phe-Asn-Ser-Tyr-Pro-Arg-Thr-Asn-Val-Gly-Ala-Gly-Thr-Pro-NH ₂ . Some portions of this sequence are specific to bullfrog calcitonin, and other portions are similar both to teleost calcitonins...

article

Inhibition of ICE-Related Proteases (Caspases) and Nuclear Apoptosis by Phenylarsine Oxide

Atsushi Takahashi, Pascal J. Goldschmidt-Clermont, Emad S. Alnemri, Teresa Fernandes-Alnemri, more

Experimental Cell Research > 1997 > 231 > 1 > 123-131

Biochemical analyses of nuclear apoptosisin vitrohave revealed the existence of multiple active interleukin-1β-converting enzyme-related proteases (caspases) with distinct substrate recognition properties in extracts of preapoptotic chicken DU249 cells (S/M extracts). Previously we demonstrated that the activity of a caspase that cleaves lamins is required for the disintegration of nuclei in the late...

article

Improvement in the oxidative folding of endothelin-1 by a Lys-Arg extension at the amino terminus: Implication of a salt bridge between Arg^-1 and Asp⁸

Shigeru Kubo, Naoyoshi Chino, Kiichiro Nakajima, André Aumelas, more

International Journal of Peptide Research and Therapeutics > 1997 > 4 > 3 > 185-192

An amino-terminal extension of endothelin-1 by the Lys-Arg dipeptide in the prosequence (KR-ET-1) greatly increased the ratio of native-type to non-native-type disulfide isomer (96/4 versus 71/29) during the oxidative folding reaction. This improvement was completely abolished by substituting Asn for Asp at position 8 (D8N-KR-ET-1), whereas most of it was maintained with similar carboxamide analogues...

article

Synthetic study of phosphopeptides related to heat shock protein HSP27

Tateaki Wakamiya, Ryusaku Togashi, Takatoshi Nishida, Kunio Saruta, more

Bioorganic & Medicinal Chemistry > 1997 > 5 > 1 > 135-145

Two kinds of phosphoserine-containing peptides related to HSP27 were synthesized by the Boc- or Fmoc-mode solid-phase method based on prephosphorylation strategy. In the case of the Boc strategy, the O-phosphono group of the phosphoserine residue was protected with the cyclopentyl or cyclohexyl group. On the other hand, N′-Fmoc-O-[(benzyloxy)hydroxyphosphinyl]serine was employed in case of the Fmoc...

article

Vasopressor Activities of N-Terminal Fragments of Adrenomedullin in Anesthetized Rat

Takushi X. Watanabe, Yukako Itahara, Tatsyuya Inui, Kumiko Yoshizawa-Kumagaye, more

Biochemical and Biophysical Research Communications > 1996 > 219 > 1 > 59-63

Adrenomedullin (AM) is a vasorelaxant peptide that was recently isolated from human pheochromocytoma. In contrast to human (h) AM, which has vasodepressor activity, a synthetic N-terminal fragment of hAM, hAM-(1-25)-NH ₂ showed vasopressor activity in the anesthetized rat. The N-terminal peptides hAM-(1-31)-NH ₂ , hAM-(1-25)-OH, hAM-(1-21)-NH ₂ , acetyl-hAM-(16-21)-NH ₂...

article

Specific receptors for adrenomedullin in cultured rat vascular smooth muscle cells

Satoru Eguchi, Yukio Hirata, Hiroaki Kano, Kyoko Sato, more

FEBS Letters > 1994 > 340 > 3 > 226-230

The effects of synthetic rat adrenomedullin (rAM), a novel vasorelaxant peptide originally isolated from human pheochromocytoma, on receptor binding and cAMP generation were studied in cultured rat vascular smooth muscle cells (VSMC). A binding study using [ ¹ ² ⁵ I]rAM revealed the presence of a single class of high-affinity (K _d 1.3 x 10 ^- ⁸ M) binding sites for...

article

A novel natriuretic peptide isolated from eel cardiac ventricles

Toshio Takei, Akiyoshi Takahashi, Takushi X. Watanabe, Kiichiro Nakajima, more

FEBS Letters > 1991 > 282 > 2 > 317-320

A new natriuretic peptide, which exhibits the entire spectrum of actions known to be characteristics of atrial and brain natriuretic peptides (ANP and BNP), was isolated from eel cardiac ventricles and has been named ventricular natriuretic peptide (VNP). The primary structure of eel VNP is characterized by its uniquely long C- terminal 'tall' that extends from the second half-cystine. Thus, eel VNP...

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