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Schizophrenia is associated with very high rates of tobacco smoking. The latter may be related to an attempt to self-medicate symptoms and/or to alterations in function of high-affinity β 2 -subunit-containing nicotinic acetylcholine receptors (β 2 *-nAChRs).Smoking and nonsmoking subjects with schizophrenia (n = 31) and age-, smoking-, and sex-matched comparison subjects (n = 31)...
The uncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist, ketamine, induces a range of symptoms resembling those seen in schizophrenia. Enhancement of nicotinic acetylcholine receptor (nAChR) function may have potential as a treatment for the cognitive deficits and negative symptoms of schizophrenia. Accordingly, we examined the modulatory effects of brain nAChR systems on NMDAR antagonist-induced...
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