Search results for: Brian Pittman

Items from 1 to 20 out of 77 results

article

Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial

Carlos M. Grilo, Janet A. Lydecker, Ania M. Jastreboff, Brian Pittman, more

Obesity > 31 > 11 > 2762 - 2773

Objective Binge‐eating disorder (BED) is a prevalent psychiatric disorder associated with obesity. Few evidence‐based treatments exist for BED, particularly pharmacological options. This study tested the efficacy of naltrexone/bupropion for BED. Methods A randomized, double‐blind, placebo‐controlled, 12‐week trial tested naltrexone/bupropion for BED with and without obesity. Eighty‐nine patients...

article

Delta‐9‐tetrahydrocannabinol modulates pain sensitivity among persons receiving opioid agonist therapy for opioid use disorder: A within‐subject, randomized, placebo‐controlled laboratory study

Joao P. De Aquino, Julia Meyerovich, Catherine Z. Xie, Mohini Ranganathan, more

Addiction Biology > 28 > 9 > n/a - n/a

The opioid and cannabinoid receptor systems are inextricably linked—overlapping at the anatomical, functional and behavioural levels. Preclinical studies have reported that cannabinoid and opioid agonists produce synergistic antinociceptive effects. Still, there are no experimental data on the effects of cannabinoid agonists among humans who receive opioid agonist therapies for opioid use disorder...

article

Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender

Sheida Koohsari, Faranak Ebrahimian Sadabad, Brian Pittman, Jean‐Dominque Gallezot, more

Synapse > 77 > 5 > n/a - n/a

Previous research reported an age‐related decline in brain norepinephrine transporter (NET) using (S, S)‐[11C]O‐methylreboxetine ([11C]MRB) as a radiotracer. Studies with the same tracer have been mixed in regard to differences related to body mass index (BMI). Here, we investigated potential age‐, BMI‐, and gender‐related differences in brain NET availability using [11C]MRB, the most selective available...

article

Dorsal bed nucleus of stria terminalis in depressed and nondepressed temporal lobe epilepsy patients

Roni Dhaher, Richard A. Bronen, Linda Spencer, Lejla Colic, more

Epilepsia > 63 > 10 > 2561 - 2570

Objective Temporal lobe epilepsy (TLE) and depression are common comorbid disorders whose underlying shared neural network has yet to be determined. Although animal studies demonstrate a role for the dorsal bed nucleus of the stria terminalis (dBNST) in both seizures and depression, and human clinical studies demonstrate a therapeutic effect of stimulating this region on treatment‐resistant depression,...

article

A graph theory‐based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorder

Danielle A. Goldman, Anjali Sankar, Lejla Colic, Luca Villa, more

Bipolar Disorders > 24 > 4 > 412 - 423

Objectives Identifying hubs of brain dysfunction in adolescents and young adults with Bipolar I Disorder (BD_AYA) could provide targets for early detection, prevention, and treatment. Previous neuroimaging studies across mood states of BD_AYA are scarce and often examined limited brain regions potentially prohibiting detection of other important regions. We used a data‐driven whole‐brain Intrinsic...

article

Sensitivity, specificity, and tolerability of the BACTrack Skyn compared to other alcohol monitoring approaches among young adults in a field‐based setting

Garrett I. Ash, Ralitza Gueorguieva, Nancy P. Barnett, Wuyi Wang, more

Alcoholism: Clinical and Experimental Research > 46 > 5 > 783 - 796

Background There is a need for novel alcohol biosensors that are accurate, able to detect alcohol concentration close in time to consumption, and feasible and acceptable for many clinical and research applications. We evaluated the field accuracy and tolerability of novel (BACTrack Skyn) and established (Alcohol Monitoring Systems SCRAM CAM) alcohol biosensors. Methods The sensor and diary data...

article

Sexual minority disparities in opioid and benzodiazepine misuse among adults with opioid use disorder

Cara A. Struble, Kathryn Thomas, Madeline R. Stenersen, Kelly E. Moore, more

The American Journal on Addictions > 31 > 3 > 200 - 209

Background and Objectives Sexual minority individuals demonstrate disparate rates of substance use. Research suggests that bisexual women are vulnerable to substance use disorders when compared to other sexual minority groups. This study explored differences in prevalence of past‐year alcohol use disorder (AUD) with and without concurrent past‐year opioid and/or benzodiazepine misuse. Methods The...

chapter

Synaptic changes in Parkinson disease assessed with in vivo imaging

David Matuskey, Sule Tinaz, Kyle C Wilcox, Mika Naganawa, more

329-338

Objective Parkinson disease is characterized by motor and nonmotor symptoms, reduced striatal dopamine signaling, and loss of dopamine neurons in the substantia nigra. It is now known that the pathological process in Parkinson disease may begin decades before the clinical diagnosis and include a variety of neuronal alterations in addition to the dopamine system. Methods This study examined...

article

Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory ¹¹C‐UCB‐J positron emission tomography study in humans

Gustavo A. Angarita, Patrick D. Worhunsky, Mika Naganawa, Takuya Toyonaga, more

Addiction Biology > 27 > 2 > n/a - n/a

Preclinical studies have revealed robust and long‐lasting alterations in dendritic spines in the brain following cocaine exposure. Such alterations are hypothesized to underlie enduring maladaptive behaviours observed in cocaine use disorder (CUD). The current study explored whether synaptic density is altered in CUD. Fifteen individuals with DSM‐5 CUD and 15 demographically matched healthy control...

article

Examining depression scores as predictors and moderators of treatment outcomes in patients with binge‐eating disorder

Carlos M. Grilo, Ralitza Gueorguieva, Brian Pittman

International Journal of Eating Disorders > 54 > 8 > 1555 - 1559

Objective A substantial proportion of patients with binge‐eating disorder (BED) do not derive sufficient benefits from available evidence‐based psychological interventions. We examined depression scores as predictors and moderators of response to cognitive‐behavioral therapy (CBT) and behavioral weight‐loss (BWL) for BED. We explored associations between changes in depression scores and changes in...

article

Altered frontal cortex functioning in emotion regulation and hopelessness in bipolar disorder

Anjali Sankar, Kirstin Purves, Lejla Colic, Elizabeth T. Cox Lippard, more

Bipolar Disorders > 23 > 2 > 152 - 164

Objectives Emotion regulation difficulties precipitate and exacerbate acute mood symptoms in individuals with bipolar disorder (BD), and contribute to suicidal behavior. However, few studies have examined regional brain responses in explicit emotion regulation during acute BD mood states, or hopelessness, a major suicide risk factor. We assessed brain responses during explicit emotion regulation,...

article

Examining the Relationship Between Self‐Reported Drinking and In‐Laboratory Drinking and Craving: Is There Concordance?

Kelly S. DeMartini, Brian Pittman, John H. Krystal, Stephanie S. O’Malley, more

Alcoholism: Clinical and Experimental Research > 44 > 5 > 1151 - 1157

Background In‐laboratory drinking sessions that allow direct assessment of drinking and craving are an emerging method for testing novel pharmacotherapy compounds and behavioral interventions for alcohol use disorders. Despite wide implementation, limited evidence supports the concordance between drinking in the laboratory and in a natural setting. This study examined the relationship between self‐reports...

article

Synaptic Changes in Parkinson Disease Assessed with in vivo Imaging

David Matuskey, Sule Tinaz, Kyle C. Wilcox, Mika Naganawa, more

Annals of Neurology > 87 > 3 > 329 - 338

article

Effects of age, BMI and sex on the glial cell marker TSPO — a multicentre [¹¹C]PBR28 HRRT PET study

Jouni Tuisku, Pontus Plavén-Sigray, Edward C. Gaiser, Laura Airas, more

European Journal of Nuclear Medicine and Molecular Imaging > 2019 > 46 > 11 > 2329-2338

Purpose The purpose of this study was to investigate the effects of ageing, sex and body mass index (BMI) on translocator protein (TSPO) availability in healthy subjects using positron emission tomography (PET) and the radioligand [¹¹C]PBR28. Methods [¹¹C]PBR28 data from 140 healthy volunteers (72 males and 68 females; N = 78 with HAB and N = 62 MAB genotype; age range 19–80 years; BMI range 17...

article

Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humans

Mohini Ranganathan, Joao P. De Aquino, Jose A. Cortes-Briones, Rajiv Radhakrishnan, more

Psychopharmacology > 2019 > 236 > 11 > 3209-3219

Rationale The catechol-O-methyl transferase (COMT) enzyme has been implicated in determining dopaminergic tone and the effects of delta-9-tetrahydrocannabinol (THC) in the human brain. Objective This study was designed to evaluate the effect of (1) a functional polymorphism and (2) acute pharmacological inhibition of COMT on the acute response to THC in humans. Methods Sub-study I: The effect...

article

Dynamic functional connectivity in schizophrenia and autism spectrum disorder: Convergence, divergence and classification

Liron Rabany, Sophy Brocke, Vince D. Calhoun, Brian Pittman, more

NeuroImage: Clinical > 2019 > 24 > C

Over the recent years there has been a growing debate regarding the extent and nature of the overlap in neuropathology between schizophrenia (SZ) and autism spectrum disorder (ASD). Dynamic functional network connectivity (dFNC) is a recent analysis method that explores temporal patterns of functional connectivity (FC). We compared resting-state dFNC in SZ, ASD and healthy controls (HC), characterized...

article

Corrigendum to “Dynamic functional connectivity in schizophrenia and autism spectrum disorder: Convergence, divergence and classification” [NeuroImage: Clinical, 24, 2019 / 101966]

Liron Rabany, Sophy Brocke, Vince D. Calhoun, Brian Pittman, more

NeuroImage: Clinical > 2019 > 24 > C

article

Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia Subjects

Deepak Cyril D’Souza, Richard E. Carson, Naomi Driesen, Jason Johannesen, more

Biological Psychiatry > 2018 > 84 > 6 > 413-421

Glycine transporter-1 (GlyT1) inhibitors may ameliorate cognitive impairments associated with schizophrenia. The dose-related occupancy and target engagement of the GlyT1 inhibitor PF-03463275 were studied to inform optimal dose selection for a clinical trial for cognitive impairments associated with schizophrenia.In substudy 1, the effects of PF-03463275 (10, 20, and 40 mg twice a day) on occupancy...

article

The effects of cannabidiol (CBD) on cognition and symptoms in outpatients with chronic schizophrenia a randomized placebo controlled trial

Douglas L. Boggs, Toral Surti, Aarti Gupta, Swapnil Gupta, more

Psychopharmacology > 2018 > 235 > 7 > 1923-1932

Rationale Preliminary evidence suggests that cannabidiol (CBD) may be effective in the treatment of neurodegenerative disorders; however, CBD has never been evaluated for the treatment of cognitive impairments associated with schizophrenia (CIAS). Objective This study compared the cognitive, symptomatic, and side effects of CBD versus placebo in a clinical trial. Methods This study was a 6-week,...

article

Tetrahydrocannabinol (THC) impairs encoding but not retrieval of verbal information

Mohini Ranganathan, Rajiv Radhakrishnan, Peter H. Addy, Ashley M. Schnakenberg-Martin, more

Progress in Neuro-Psychopharmacology and Biological Psychiatry > 2017 > 79 > PB > 176-183

Cannabis and agonists of the brain cannabinoid receptor (CB₁R) produce acute memory impairments in humans. However, the extent to which cannabinoids impair the component processes of encoding and retrieval has not been established in humans. The objective of this analysis was to determine whether the administration of Δ⁹-Tetrahydrocannabinol (THC), the principal psychoactive constituent of cannabis,...

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INFONA - science communication portal

Search results for: Brian Pittman

Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial

Delta‐9‐tetrahydrocannabinol modulates pain sensitivity among persons receiving opioid agonist therapy for opioid use disorder: A within‐subject, randomized, placebo‐controlled laboratory study

Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender

Dorsal bed nucleus of stria terminalis in depressed and nondepressed temporal lobe epilepsy patients

A graph theory‐based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorder

Sensitivity, specificity, and tolerability of the BACTrack Skyn compared to other alcohol monitoring approaches among young adults in a field‐based setting

Sexual minority disparities in opioid and benzodiazepine misuse among adults with opioid use disorder

Synaptic changes in Parkinson disease assessed with in vivo imaging

Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory ¹¹C‐UCB‐J positron emission tomography study in humans

Examining depression scores as predictors and moderators of treatment outcomes in patients with binge‐eating disorder

Altered frontal cortex functioning in emotion regulation and hopelessness in bipolar disorder

Examining the Relationship Between Self‐Reported Drinking and In‐Laboratory Drinking and Craving: Is There Concordance?

Synaptic Changes in Parkinson Disease Assessed with in vivo Imaging

Effects of age, BMI and sex on the glial cell marker TSPO — a multicentre [¹¹C]PBR28 HRRT PET study

Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humans

Dynamic functional connectivity in schizophrenia and autism spectrum disorder: Convergence, divergence and classification

Corrigendum to “Dynamic functional connectivity in schizophrenia and autism spectrum disorder: Convergence, divergence and classification” [NeuroImage: Clinical, 24, 2019 / 101966]

Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia Subjects

The effects of cannabidiol (CBD) on cognition and symptoms in outpatients with chronic schizophrenia a randomized placebo controlled trial

Tetrahydrocannabinol (THC) impairs encoding but not retrieval of verbal information

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