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The objective of the present study was to figure out whether human IL-27-producing CD4 + T cells represent a distinct T cell subset in tuberculosis pleural effusion (TPE).Distribution, phenotypic features of IL-27-producing CD4 + T cells in TPE were determined. The required transcription factors and signal transductions for IL-27-producing CD4 + T cell differentiation were...
Programmed death 1 (PD-1), PD-ligand 1 (PD-L1), and PD-L2 have been demonstrated to be involved in tuberculosis immunity, however, the expression and regulation of PD-1/PD-Ls pathways in pleural mesothelial cells (PMCs) and CD4 + T cells in tuberculous pleural effusion (TPE) have not been investigated.Expression of PD-1 on CD4 + T cells and expressions of PD-L1 and PD-L2 on PMCs in...
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