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Recently, hyperpolarized substrates generated through dynamic nuclear polarization have been introduced to study in vivo metabolism. Injection of hyperpolarized [1-13C] pyruvate, the most widely used substrate, allows detection of time courses of [1-13C] pyruvate and its metabolic products, such as [1-13C] lactate and 13C-bicarbonate, in various organs. However, quantitative metabolic modeling of...
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