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Encapsulation and transplantation of insulin‐producing cells offer a promising curative treatment for type 1 diabetes (T1D) without immunosuppression. However, biomaterials used to encapsulate cells often elicit foreign body responses, leading to cellular overgrowth and deposition of fibrotic tissue, which in turn diminishes mass transfer to and from transplanted cells. Meanwhile, the encapsulation...
Thin, conformal coatings on cell membranes provide potential solutions to many of the challenges associated with cellular therapies. These coatings can protect transplanted cells from the host immune system, yet because of their thin nature, minimally impede nutrient transport and do not significantly increase the transplant volume. In addition, active agents and therapeutics may be embedded within...
Cell encapsulation holds enormous potential to treat a number of hormone deficient diseases and endocrine disorders. We report a simple and universal approach to fabricate robust, hydrogel-based, nanofiber-enabled encapsulation devices (NEEDs) with macroscopic dimensions. In this design, we take advantage of the well-known capillary action that holds wetting liquid in porous media. By impregnating...
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