Search results for: Lissa C. Anderson

Items from 1 to 9 out of 9 results

article

Ion-Ion Proton Transfer and Parallel Ion Parking for the Analysis of Mixtures of Intact Proteins on a Modified Orbitrap Mass Analyzer

Scott A. Ugrin, A. Michelle English, John E. P. Syka, Dina L. Bai, more

Journal of The American Society for Mass Spectrometry > 2019 > 30 > 10 > 2163-2173

We have enabled parallel ion parking on a modified Orbitrap Elite™ as a way to control ion-ion proton transfer reactions via selective activation of a range of ions. The result is the concentration of the majority of ion current from multiple charge states of each precursor proteoform into a single charge state, maximizing signal intensity and increasing effective sensitivity compared to conventional...

article

Back Cover: Identification and Quantification of Proteoforms by Mass Spectrometry

Leah V. Schaffer, Robert J. Millikin, Rachel M. Miller, Lissa C. Anderson, more

PROTEOMICS > 19 > 10 > n/a - n/a

DOI: 10.1002/pmic.201800361 A proteoform is a defined form of a protein derived from a given gene with a specific amino acid sequence and localized post‐translational modifications. In top‐down proteomic analyses, proteoforms are identified and quantified through mass spectrometric analysis of intact proteins. Recent technological developments have enabled comprehensive proteoform analyses in complex...

article

Identification and Quantification of Proteoforms by Mass Spectrometry

Leah V. Schaffer, Robert J. Millikin, Rachel M. Miller, Lissa C. Anderson, more

PROTEOMICS > 19 > 10 > n/a - n/a

A proteoform is a defined form of a protein derived from a given gene with a specific amino acid sequence and localized post‐translational modifications. In top‐down proteomic analyses, proteoforms are identified and quantified through mass spectrometric analysis of intact proteins. Recent technological developments have enabled comprehensive proteoform analyses in complex samples, and an increasing...

article

Front-End Electron Transfer Dissociation Coupled to a 21 Tesla FT-ICR Mass Spectrometer for Intact Protein Sequence Analysis

Chad R. Weisbrod, Nathan K. Kaiser, John E. P. Syka, Lee Early, more

Journal of The American Society for Mass Spectrometry > 2017 > 28 > 9 > 1787-1795

High resolution mass spectrometry is a key technology for in-depth protein characterization. High-field Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) enables high-level interrogation of intact proteins in the most detail to date. However, an appropriate complement of fragmentation technologies must be paired with FTMS to provide comprehensive sequence coverage, as well as...

article

Intact Protein Analysis at 21 Tesla and X-Ray Crystallography Define Structural Differences in Single Amino Acid Variants of Human Mitochondrial Branched-Chain Amino Acid Aminotransferase 2 (BCAT2)

Lissa C. Anderson, Maria Håkansson, Björn Walse, Carol L. Nilsson

Journal of The American Society for Mass Spectrometry > 2017 > 28 > 9 > 1796-1804

Structural technologies are an essential component in the design of precision therapeutics. Precision medicine entails the development of therapeutics directed toward a designated target protein, with the goal to deliver the right drug to the right patient at the right time. In the field of oncology, protein structural variants are often associated with oncogenic potential. In a previous proteogenomic...

article

Erratum to: Analysis of Monoclonal Antibodies in Human Serum as a Model for Clinical Monoclonal Gammopathy by Use of 21 Tesla FT-ICR Top-Down and Middle-Down MS/MS

Lidong He, Lissa C. Anderson, David R. Barnidge, David L. Murray, more

Journal of The American Society for Mass Spectrometry > 2017 > 28 > 5 > 839-839

The online version of the original article can be found at http://dx.doi.org/10.1007/s13361-017-1602-6

article

Analysis of Monoclonal Antibodies in Human Serum as a Model for Clinical Monoclonal Gammopathy by Use of 21 Tesla FT-ICR Top-Down and Middle-Down MS/MS

Lidong He, Lissa C. Anderson, David R. Barnidge, David L. Murray, more

Journal of The American Society for Mass Spectrometry > 2017 > 28 > 5 > 827-838

With the rapid growth of therapeutic monoclonal antibodies (mAbs), stringent quality control is needed to ensure clinical safety and efficacy. Monoclonal antibody primary sequence and post-translational modifications (PTM) are conventionally analyzed with labor-intensive, bottom-up tandem mass spectrometry (MS/MS), which is limited by incomplete peptide sequence coverage and introduction of artifacts...

article

Protein derivatization and sequential ion/ion reactions to enhance sequence coverage produced by electron transfer dissociation mass spectrometry

Lissa C. Anderson, A. Michelle English, Wei-Han Wang, Dina L. Bai, more

International Journal of Mass Spectrometry > 2015 > 377 > C > 617-624

Previously, we described implementation of a front-end ETD (electron transfer dissociation) source for an Orbitrap instrument [1]. This source facilitates multiple fills of the C-trap with product ions from ETD of intact proteins prior to mass analysis. The result is a dramatic enhancement of the observed ion current without the need for time consuming averaging of data from multiple mass measurements...

article

Phosphorylation and arginine methylation mark histone H2A prior to deposition during Xenopus laevis development

Wei-Lin Wang, Lissa C Anderson, Joshua J Nicklay, Hongshan Chen, more

Epigenetics & Chromatin > 2014 > 7 > 1 > 1-20

Background Stored, soluble histones in eggs are essential for early development, in particular during the maternally controlled early cell cycles in the absence of transcription. Histone post-translational modifications (PTMs) direct and regulate chromatin-templated transactions, so understanding the nature and function of pre-deposition maternal histones is essential to deciphering mechanisms...

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ETD (3)
FTMS (2)
MS/MS (2)
TOP-DOWN (2)
XENOPUS LAEVIS (1)
BIOINFORMATICS (1)
CID (1)
COLLISION-INDUCED DISSOCIATION (1)
COLLISIONALLY INDUCED DISSOCIATION (1)
EARLY DEVELOPMENT (1)
ELECTRON TRANSFER DISSOCIATION (1)
ELECTRON-TRANSFER DISSOCIATION (1)
ELECTROSPRAY (1)
ELECTROSPRAY IONIZATION (1)
FOURIER TRANSFORM (1)
FOURIER TRANSFORM MASS SPECTROMETRY (1)
H2A (1)
HIGH FIELD FOURIER TRANSFORM MASS SPECTROMETRY (1)
HIGH RESOLUTION (1)
HISTONE ARGININE METHYLATION (1)
HISTONE DEPOSITION (1)
HISTONE PHOSPHORYLATION (1)
HISTONES (1)
IIPT (1)
INTACT PROTEIN (1)
ION CYCLOTRON RESONANCE (1)
ION-ION PROTON TRANSFER REACTIONS (1)
ION-ION REACTION (1)
ISOTYPE (1)
MASS SPECTROMETRY (1)
MIDDLE-DOWN (1)
MS2 (1)
MULTIPLE MYELOMA (1)
PARALLEL ION PARKING (1)
PRECISION MEDICINE (1)
PROTEIN DERIVATIZATION (1)
PROTEIN SEQUENCE VARIANT (1)
PROTEIN STRUCTURE (1)
PROTEOFORM (1)
PROTEOFORM FAMILY (1)
QUADRUPOLE LINEAR ION TRAP (1)
REAGENT ACTIVATION (1)
TOP‐DOWN PROTEOMICS (1)
VARIABLE REGION (1)
X RAY CRYSTALLOGRAPHY (1)
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Search results for: Lissa C. Anderson

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