Search results for: Claudia A. M. Wheeler-Kingshott

Items from 1 to 12 out of 12 results

chapter

In-Vivo Estimates of Axonal Characteristics Using Optimized Diffusion MRI Protocols for Single Fibre Orientation

Torben Schneider, Claudia A. M. Wheeler-Kingshott, Daniel C. Alexander

Lecture Notes in Computer Science > Medical Image Computing and Computer-Assisted Intervention – MICCAI 2010 > Diffusion Tensor MR Imaging and Analysis > 623-630

This work presents diffusion MR protocols that allow estimation of axonal parameters like diameter and density in the live human brain. Previous approaches demand very high field experimental systems or suffer from long acquisition times and are therefore impractical for use in clinical studies. We propose a method that significantly reduces scan time by making use of the a-priori known fibre orientation...

article

Complex motor task associated with non-linear BOLD responses in cerebro-cortical areas and cerebellum

Adnan A. S. Alahmadi, Rebecca S. Samson, David Gasston, Matteo Pardini, more

Brain Structure and Function > 2016 > 221 > 5 > 2443-2458

Previous studies have used fMRI to address the relationship between grip force (GF) applied to an object and BOLD response. However, whilst the majority of these studies showed a linear relationship between GF and neural activity in the contralateral M1 and ipsilateral cerebellum, animal studies have suggested the presence of non-linear components in the GF–neural activity relationship. Here, we present...

article

Contralateral cerebello-thalamo-cortical pathways with prominent involvement of associative areas in humans in vivo

Fulvia Palesi, Jacques-Donald Tournier, Fernando Calamante, Nils Muhlert, more

Brain Structure and Function > 2015 > 220 > 6 > 3369-3384

In addition to motor functions, it has become clear that in humans the cerebellum plays a significant role in cognition too, through connections with associative areas in the cerebral cortex. Classical anatomy indicates that neo-cerebellar regions are connected with the contralateral cerebral cortex through the dentate nucleus, superior cerebellar peduncle, red nucleus and ventrolateral anterior nucleus...

article

A ranking of diffusion MRI compartment models with in vivo human brain data

Uran Ferizi, Torben Schneider, Eleftheria Panagiotaki, Gemma Nedjati‐Gilani, more

Magnetic Resonance in Medicine > 72 > 6 > 1785 - 1792

PurposeDiffusion magnetic resonance imaging (MRI) microstructure imaging provides a unique noninvasive probe into tissue microstructure. The technique relies on biophysically motivated mathematical models, relating microscopic tissue features to the magnetic resonance (MR) signal. This work aims to determine which compartment models of diffusion MRI are best at describing measurements from in vivo...

article

Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging

Olga Ciccarelli, Frederik Barkhof, Benedetta Bodini, Nicola De Stefano, more

The Lancet Neurology > 2014 > 13 > 8 > 807-822

The mechanisms underlying the pathogenesis of multiple sclerosis induce the changes that underpin relapse-associated and progressive disability. Disease mechanisms can be investigated in preclinical models and patients with multiple sclerosis by molecular and metabolic imaging techniques. Many insights have been gained from such imaging studies: persisting inflammation in the absence of a damaged...

article

Multicenter $R_{2}^{*}$ mapping in the healthy brain

Stefan Ropele, Mike P. Wattjes, Christian Langkammer, Iris D. Kilsdonk, more

Magnetic Resonance in Medicine > 71 > 3 > 1103 - 1107

PurposeThe

R_{2}^{*}

relaxation rate constant has been suggested as a sensitive measure for iron accumulation. The aim of this multi‐center study was to assess the inter‐scanner and inter‐subject variability of

R_{2}^{*}

mapping and to investigate the relationship between brain volume and

R_{2}^{*}

in specific structures. Methods

R_{2}^{*}

mapping was performed in 81 healthy subjects in seven centers using different 3...

article

Sodium (²³Na) ultra-short echo time imaging in the human brain using a 3D-Cones trajectory

Frank Riemer, Bhavana S. Solanky, Christian Stehning, Matthew Clemence, more

Magnetic Resonance Materials in Physics, Biology and Medicine > 2014 > 27 > 1 > 35-46

Object Sodium magnetic resonance imaging (²³Na-MRI) of the brain has shown changes in ²³Na signal as a hallmark of various neurological diseases such as stroke, Alzheimer’s disease, Multiple Sclerosis and Huntington’s disease. To improve scan times and image quality, we have implemented the 3D-Cones (CN) sequence for in vivo ²³Na brain MRI. Materials and methods Using signal-to-noise (SNR) as a...

article

Low Myo‐inositol indicating astrocytic damage in a case series of neuromyelitis optica

Olga Ciccarelli, David L. Thomas, Enrico Vita, Claudia A. M. Wheeler‐Kingshott, more

Annals of Neurology > 74 > 2 > 301 - 305

Astrocytic necrosis is a prominent pathological feature of neuromyelitis optica (NMO) lesions and is clinically relevant. We report 5 NMO‐related cases, all with longitudinally extensive lesions in the upper cervical cord, who underwent cervical cord ¹H‐magnetic resonance spectroscopy. Lower myo‐inositol/creatine values, suggesting astrocytic damage, were consistently found within the NMO lesions...

article

Sodium quantification in the spinal cord at 3T

Bhavana S. Solanky, Frank Riemer, Xavier Golay, Claudia A. M. Wheeler‐Kingshott

Magnetic Resonance in Medicine > 69 > 5 > 1201 - 1208

Purpose:Sodium channels are involved in neuronal function and therefore methods to assess tissue sodium concentration in vivo are exceptionally appealing. Recently there has been a renewed interest for brain sodium magnetic resonance imaging (MRI), thanks to higher magnetic field strength scanners. However, sodium measures in the spinal cord are lacking due to major technical challenges. Here we propose...

chapter

Ranking diffusion-MRI models with in-vivo human brain data

Uran Ferizi, Torben Schneider, Eleftheria Panagiotaki, Gemma Nedjati-Gilani, more

2013 IEEE 10th International Symposium on Biomedical Imaging > 676 - 679

2013 IEEE 10th International Symposium on Biomedical Imaging (ISBI 2013)

Diffusion MRI microstructure imaging provides a unique non-invasive probe into the microstructure of biological tissue. Its analysis relies on mathematical models relating microscopic tissue features to the MR signal. This work aims to determine which compartment models of diffusion MRI are best at describing the signal from in-vivo brain white matter. Recent work shows that three compartment models,...

article

Reproducibility of brain ADC histograms

Stefan C. A. Steens, Faiza Admiraal-Behloul, Jorrit A. Schaap, Frank G. C. Hoogenraad, more

European Radiology > 2004 > 14 > 3 > 425-430

The aim of this study was to assess the effect of differences in acquisition technique on whole-brain apparent diffusion coefficient (ADC) histogram parameters, as well as to assess scanrescan reproducibility. Diffusion-weighted imaging (DWI) was performed in 7 healthy subjects with b-values 0800, 01000, and 01500s/mm2 and fluid-attenuated inversion recovery (FLAIR) DWI with b-values 01000s/mm2. All...

article

A study of the mechanisms of normal-appearing white matter damage in multiple sclerosis using diffusion tensor imaging Evidence of Wallerian degeneration

Olga Ciccarelli, David J. Werring, Gareth J. Barker, Colette M. Griffin, more

Journal of Neurology > 2003 > 250 > 3 > 287-292

Abstract. Diffusion tensor imaging (DTI) investigates brain tissue microstructure in vivo. In multiple sclerosis (MS) Wallerian degeneration of axons traversing focal lesions is a potential mechanism of damage in normal-appearing white matter. In vivo evidence for this hypothesis is limited. The present study investigated the relationship between DTI-derived indices in the normal-appearing corpus...

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