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Hereditary breast cancer has been associated with mutations in the BRCA1 and BRCA2 genes and has a natural history different from sporadic breast cancer. We investigated disease-free and overall survival for patients with a proven BRCA1 alteration. We estimated disease-free and overall survival for 49 Dutch patients from 19 consecutive families with a proven specific BRCA1 mutation and one family...
Previous studies showed that blood large granular lymphocytes (LGL), which possess natural killer (NK) activity, develop within rat liver sinusoids into high-density (HD) and subsequently into low-density (LD) pit cells which show an increasing level and spectrum of tumor cytotoxicity. In this study, we investigated the role of adhesion molecules, such as CD2, CD11a, CD18, and CD54 in the recruitment...
The clinical data of 2273 pts with primary breast cancer and known ER status were collected: mean age 56 yr (22-89 yr); premenopausal 41%; T 1 = 43%, T 2 = 45%, T 3 T 4 = 11%; N 0 = 46%, N 1-3 = 27%, N 4-9 = 17%, N =< 10 = 10%; ER + = 78%, PgR + = 72%; median follow-up 6 yr; adj. syst. ther...
The endocrine and antitumor effects of first-line combined LHRH-A (buserelin implant sc/8 wk) and TAM (40 mg/day) therapy were compared with those of each drug alone. ER/PR-negative pts or pts with unknown ER/PR status with DFS < 2 yr were excluded. From 160 pts randomized between 1988-1995 140 thus far are evaluable. There were no major differences between the 3 treatment groups regarding patient...
A family history is one of the major risk factors of breast cancer. We studied the histologic findings in prophylactically removed breasts. Prophylactic bilateral mastectomy was performed either because of a proven BRCA1 mutation, or because of psychological distress as a consequence of a high risk based on the pedigree. In a number of 22 mastectomy specimens a high frequency of fibrocystic changes...
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