Search results for: Éva Pállinger

Items from 1 to 20 out of 44 results

article

Characterization of Electrospun Polysuccinimide‐Dopamine Conjugates and Effect on Cell Viability and Uptake

Krisztina Tóth, Krisztina S. Nagy, Zeliha Güler, Ákos György Juhász, more

Macromolecular Bioscience > 23 > 3 > n/a - n/a

Biocompatible nanofibrous systems made by electrospinning have been studied widely for pharmaceutical applications since they have a high specific surface and the capability to make the entrapped drug molecule amorphous, which increases bioavailability. By covalently conjugating drugs onto polymers, the degradation of the drug as well as the fast clearance from the circulation can be avoided. Although...

article

Characterization of immune checkpoint inhibitor‐induced cardiotoxicity reveals interleukin‐17A as a driver of cardiac dysfunction after anti‐PD‐1 treatment

Tamás G. Gergely, Dániel Kucsera, Viktória E. Tóth, Tamás Kovács, more

British Journal of Pharmacology > 180 > 6 > 740 - 761

Background and Purpose Immune checkpoint inhibitors (ICI), such as anti‐PD‐1 monoclonal antibodies, have revolutionized cancer therapy by enhancing the cytotoxic effects of T‐cells against tumours. However, enhanced T‐cell activity also may cause myocarditis and cardiotoxicity. Our understanding of the mechanisms of ICI‐induced cardiotoxicity is limited. Here, we aimed to investigate the effect of...

article

Functional and cell surface characteristics of periodontal ligament cells (PDLCs) on RGD‐synthetic polypeptide conjugate coatings

Zambaga Khorolsuren, Orsolya Lang, Eva Pallinger, Anna Foldes, more

Journal of Periodontal Research > 55 > 5 > 713 - 723

Background and Objective Periodontal ligament cells (PDLCs) are an important source for periodontal tissue healing and regeneration. Proper cell adhesion is a key for survival of anchorage‐dependent cells and also initiates further intracellular signals for essential cellular functions. We aimed to test 3 different synthetic conjugates with integrin‐binding RGD sequence (SAK‐c[RGDfC], AK‐c[RGDfC],...

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Tight co-twin similarity of monozygotic twins for hTERT protein level of T cell subsets, for telomere length and mitochondrial DNA copy number, but not for telomerase activity

Dóra Melicher, Anett Illés, Éva Pállinger, Árpád Ferenc Kovács, more

Cellular and Molecular Life Sciences > 2018 > 75 > 13 > 2447-2456

Our study analyzed lymphocyte subpopulations of 32 monozygotic twins and compared the level of the catalytic reverse transcriptase protein subunit (hTERT) in T lymphocytes (Tly), helper- (Th), cytotoxic- (Tc) and regulatory T cell (Treg) subgroups. Four variables related to telomere and mitochondrial biology were simultaneously assessed, applying multi-parametric flow cytometry, TRAP-ELISA assay and...

article

Diurnal variation of circulating microvesicles is associated with the severity of obstructive sleep apnoea

András Bikov, László Kunos, Éva Pállinger, Zsófia Lázár, more

Sleep and Breathing > 2017 > 21 > 3 > 595-600

Purpose Microvesicles (MVs) have been implicated in the pathomechanism of obstructive sleep apnoea (OSA); however, the results are inconsistent, possibly due to an unrevealed temporal variation in circulating MV levels. We aimed to investigate the diurnal changes of MV fractions in OSA. Methods Peripheral blood was taken from 18 patients with OSA and 9 healthy subjects at different time points (11:00,...

article

Synthesis, conformation and cytotoxicity of new, branched polymeric polypeptides containing hydrophobic amino acid or arginine moiety

Mónika Sebestyén, Rita Szabó, László Kőhidai, Éva Pállinger, more

Structural Chemistry > 2017 > 28 > 2 > 527-535

In this paper we report on the synthesis and solution conformation of a new set of structurally related polycationic branched chain polypeptides (poly[Lys(X_i-dl-Ala_m)]) with hydrophobic (Ile, Nle, Val) or cationic (Arg) amino acids at the N-terminal end of the side chains as well as their cytotoxic effect on murine bone marrow derived macrophages. Solution conformation of the polypeptides was studied...

article

O72. Monocyte–macrophage system in pregnancy complications from the prospective of extracellular vesicles

Éva Pállinger, Nóra Fekete, Anikó Árokszállási, József Gábor Joó, more

Pregnancy Hypertension: An International Journal of Women's Cardiovascular... > 2015 > 5 > 3 > 227

Successful pregnancy is based on the immunological balance between the maternal immunity and the feto-placental immune system. The activity of the monocyte–macrophage (MO–Mph) system is a critical step in placental homeostasis. The bilateral effects between MO–Mph-derived extracellular vesicles (EVs) and neighboring cells or the microenvironmental EVs and MO–Mph are well-known. On the one hand, EVs...

article

O18. Oxidative stress in preeclampsia

Hajnalka Héjja, Nóra Fekete, Bálint Alasztics, József Gábor Joó, more

Pregnancy Hypertension: An International Journal of Women's Cardiovascular... > 2015 > 5 > 3 > 214

Preeclampsia (PE) is characterized by hypertension and proteinuria that affects 5–10% of pregnancies. Risk factors of PE cause the release of reactive oxygen species, which lead to increased vascular cell proliferation and hypertrophy, apoptosis, inflammation and extracellular matrix remodeling.Our purpose was the complex monitoring of in vivo oxidative stress in preeclamptic patients in order to...

article

P45. Target cells of pregnancy-associated extracellular vesicles

Árpád Ferenc Kovács, Nóra Fekete, Bálint Alasztics, József Gábor Joó, more

Pregnancy Hypertension: An International Journal of Women's Cardiovascular... > 2015 > 5 > 3 > 247

Extracellular vesicles (EVs) produced by living cells are abundant in body fluids. They have a significant role in the intercellular cross-talk. The cellular origin of circulating EVs is characteristic for pregnancy complications and may determine their regulatory effects on maternal immune system.The aim of our study was identification of the target cells of circulating EVs isolated from the blood...

article

Functional characterization of two novel non-synonymous alterations in CD46 and a Q950H change in factor H found in atypical hemolytic uremic syndrome patients

Frida C. Mohlin, Sara C. Nilsson, Tanja Kersnik Levart, Ema Golubovic, more

Molecular Immunology > 2015 > 65 > 2 > 367-376

Atypical hemolytic uremic syndrome (aHUS) is a disease of complement dysregulation, characterized by hemolytic anemia, thrombocytopenia and acute renal failure. Mutations in complement inhibitors are major risk factors for development of aHUS. The three aHUS patients reported in this study had several previously identified alterations in complement inhibitors; e.g. risk haplotypes in CD46 and factor...

article

Oxidative and other posttranslational modifications in extracellular vesicle biology

Katalin Szabó-Taylor, Brent Ryan, Xabier Osteikoetxea, Tamás G. Szabó, more

Seminars in Cell and Developmental Biology > 2015 > 40 > Complete > 8-16

Extracellular vesicles including exosomes, microvesicles and apoptotic vesicles, are phospholipid bilayer surrounded structures secreted by cells universally, in an evolutionarily conserved fashion. Posttranslational modifications such as oxidation, citrullination, phosphorylation and glycosylation play diverse roles in extracellular vesicle biology. Posttranslational modifications orchestrate the...

article

Microvesicle-associated immune regulation during pregnancy

Éva Pállinger, Attila András Kiss, András Falus, Edit Buzás

Journal of Reproductive Immunology > 2014 > 101-102 > C > 23

article

Improved circulating microparticle analysis in acid-citrate dextrose (ACD) anticoagulant tube

Bence György, Krisztina Pálóczi, Alexandra Kovács, Eszter Barabás, more

Thrombosis Research > 2014 > 133 > 2 > 285-292

Recently extracellular vesicles (exosomes, microparticles also referred to as microvesicles and apoptotic bodies) have attracted substantial interest as potential biomarkers and therapeutic vehicles. However, analysis of microparticles in biological fluids is confounded by many factors such as the activation of cells in the blood collection tube that leads to in vitro vesiculation. In this study we...

article

Critical role of extracellular vesicles in modulating the cellular effects of cytokines

Géza Tamás Szabó, Bettina Tarr, Krisztina Pálóczi, Katalin Éder, more

Cellular and Molecular Life Sciences > 2014 > 71 > 20 > 4055-4067

Under physiological and pathological conditions, extracellular vesicles (EVs) are present in the extracellular compartment simultaneously with soluble mediators. We hypothesized that cytokine effects may be modulated by EVs, the recently recognized conveyors of intercellular messages. In order to test this hypothesis, human monocyte cells were incubated with CCRF acute lymphoblastic leukemia cell...

article

Effect of different concentrations of serotonin, histamine and insulin on the hormone (serotonin and ACTH) production of Tetrahymena in nutrient-free physiological milieu

G. Csaba, Eszter Lajkó, Éva Pállinger

Experimental Parasitology > 2011 > 129 > 2 > 179-182

Cell populations of Tetrahymena pyriformis GL were kept in nutrient-free (Losina) milieu and treated with different (10 ⁻⁶ –10 ⁻²¹ M) concentrations of serotonin, histamine or insulin for 30min. Following that the hormone (serotonin and adrenocorticotropin (ACTH) content of the cells were measured by immunocytochemical flow cytometric method. Serotonin reduced histamine when applied...

article

The role of membrane vesicles in tumorigenesis

Erna Pap, Éva Pállinger, András Falus

Critical Reviews in Oncology / Hematology > 2011 > 79 > 3 > 213-223

Membrane vesicles are membrane-covered cell fragments generated by all cell types. They comprise a recently recognized new system of intercellular communication, believed to play a pivotal role in information transfer between cells, as they display a large number of biomolecules enclosed within the membrane as well as in the membrane proper. The phenotype of the donor cell is reflected in the vesicular...

article

Thyrotropin (Tsh) Regulates Triiodothyronine (T₃) Production in the Unicellular Tetrahymena

G. Csaba, Éva Pállinger

Acta Biologica Hungarica > 2011 > 62 > 3 > 228-234

The aim of the experiments was to study the regulation of triiodothyronine (T₃) production in the unicellular Tetrahymena. Untreated and troph-hormone treated specimen were prepared and in different time-points T₃ content was measured and compared by immunocytochemical flow cytometry. 0.1 or 0.001 IU TSH in tryptone-yeast medium stimulated T₃ synthesis at 10, 20, 30 min, but does not stimulate after...

article

The miR-290-295 cluster promotes pluripotency maintenance by regulating cell cycle phase distribution in mouse embryonic stem cells

Zsuzsanna Lichner, Emőke Páll, Andrea Kerekes, Éva Pállinger, more

Differentiation > 2011 > 81 > 1 > 11-24

The mmu-miR-290-295 cluster codes for a family of microRNAs (miRNAs) that are expressed de novo during early embryogenesis and are specific for mouse embryonic stem cells (ESC) and embryonic carcinoma cells (ECC). Detailed sequence analysis and alignment studies of miR-290-295 precursors demonstrated that the cluster has evolved by repeated duplication events of the ancient miR-290 precursor. We show...

article

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

Bence György, Tamás G. Szabó, Mária Pásztói, Zsuzsanna Pál, more

Cellular and Molecular Life Sciences > 2011 > 68 > 16 > 2667-2688

Release of membrane vesicles, a process conserved in both prokaryotes and eukaryotes, represents an evolutionary link, and suggests essential functions of a dynamic extracellular vesicular compartment (including exosomes, microparticles or microvesicles and apoptotic bodies). Compelling evidence supports the significance of this compartment in a broad range of physiological and pathological processes...

article

S-genotyping of old apple cultivars from the Carpathian basin: methodological, breeding and evolutionary aspects

Julia Halász, Attila Hegedűs, Zsuzsanna György, Éva Pállinger, more

Tree Genetics & Genomes > 2011 > 7 > 6 > 1135-1145

Apple exhibits self-incompatibility controlled by the multiallelic S-locus. Twenty-three old apple cultivars were S-genotyped using three different approaches (allele-specific polymerase chain reaction (PCR) + cleaved amplified polymorphic sequences (CAPS), consensus PCR + sequencing and consensus PCR + CAPS) to compare the robustness and reliability of these techniques and characterise genotypes...

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INFONA - science communication portal

Search results for: Éva Pállinger

Characterization of Electrospun Polysuccinimide‐Dopamine Conjugates and Effect on Cell Viability and Uptake

Characterization of immune checkpoint inhibitor‐induced cardiotoxicity reveals interleukin‐17A as a driver of cardiac dysfunction after anti‐PD‐1 treatment

Functional and cell surface characteristics of periodontal ligament cells (PDLCs) on RGD‐synthetic polypeptide conjugate coatings

Tight co-twin similarity of monozygotic twins for hTERT protein level of T cell subsets, for telomere length and mitochondrial DNA copy number, but not for telomerase activity

Diurnal variation of circulating microvesicles is associated with the severity of obstructive sleep apnoea

Synthesis, conformation and cytotoxicity of new, branched polymeric polypeptides containing hydrophobic amino acid or arginine moiety

O72. Monocyte–macrophage system in pregnancy complications from the prospective of extracellular vesicles

O18. Oxidative stress in preeclampsia

P45. Target cells of pregnancy-associated extracellular vesicles

Functional characterization of two novel non-synonymous alterations in CD46 and a Q950H change in factor H found in atypical hemolytic uremic syndrome patients

Oxidative and other posttranslational modifications in extracellular vesicle biology

Microvesicle-associated immune regulation during pregnancy

Improved circulating microparticle analysis in acid-citrate dextrose (ACD) anticoagulant tube

Critical role of extracellular vesicles in modulating the cellular effects of cytokines

Effect of different concentrations of serotonin, histamine and insulin on the hormone (serotonin and ACTH) production of Tetrahymena in nutrient-free physiological milieu

The role of membrane vesicles in tumorigenesis

Thyrotropin (Tsh) Regulates Triiodothyronine (T₃) Production in the Unicellular Tetrahymena

The miR-290-295 cluster promotes pluripotency maintenance by regulating cell cycle phase distribution in mouse embryonic stem cells

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

S-genotyping of old apple cultivars from the Carpathian basin: methodological, breeding and evolutionary aspects

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