Umberto Maria Marinari

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HO-1 Down-Regulation Increases the Efficacy of BRAFV600E Inhibition-Based Therapy in Primary Melanoma Cells

Anna Lisa Furfaro, Gabriella Pietra, Umberto Maria Marinari, Lorenzo Moretta, more

Free Radical Biology and Medicine > 2016 > 100 > S > S122

The inducible enzyme heme oxygenase 1 (HO-1) plays a crucial role in maintaining redox balance. Under stress conditions, HO-1 is up-regulated leading to the generation of bilirubin, ferritin and carbon monoxide, with antioxidant, antiapoptotic and anti-inflammatory properties [1]. The induction of HO-1 is involved in the gain of resistance to oxidation-based therapies and favors cancer progression...

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Neuroblastoma Cell Response to Oxidative Stress Is Impaired by Retinoic Acid-Induced Differentiation: Role of HO-1

Mariapaola Nitti, Sabrina Piras, Anna Lisa Furfaro, Lorenzo Brondolo, more

Free Radical Biology and Medicine > 2016 > 100 > S > S106-S107

The modulation of redox balance is able to drive different cell functions, from differentiation to proliferation. In a previous work, we showed that all-trans retinoic acid (ATRA) induced differentiation of SH-SY5Y neuroblastoma (NB) cells through the generation of reactive oxygen species (ROS) [Nitti et al Cell Signal 2010]. However, ATRA-differentiated NB cells resulted more sensitive to the further...

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A novel mechanism for cyclic adenosine monophosphate–mediated memory formation: Role of amyloid beta

Roberta Ricciarelli, Daniela Puzzo, Olga Bruno, Elisa Canepa, more

Annals of Neurology > 75 > 4 > 602 - 607

Cyclic adenosine monophosphate (cAMP) regulates long‐term potentiation (LTP) and ameliorates memory in healthy and diseased brain. Increasing evidence shows that, under physiological conditions, low concentrations of amyloid β (Aβ) are necessary for LTP expression and memory formation. Here, we report that cAMP controls amyloid precursor protein (APP) translation and Aβ levels, and that the modulatory...

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HO-1 up-regulation: A key point in high-risk neuroblastoma resistance to bortezomib

Anna Lisa Furfaro, Sabrina Piras, Mario Passalacqua, Cinzia Domenicotti, more

BBA - Molecular Basis of Disease > 2014 > 1842 > 4 > 613-622

High-risk neuroblastoma (NB) is characterized by the development of chemoresistance, and bortezomib (BTZ), a selective inhibitor of proteasome, has been proposed in order to overcome drug resistance. Considering the involvement of the nuclear factor-erythroid-derived 2-like 2 (Nrf2) and heme oxygenase-1 (HO-1) in the antioxidant and detoxifying ability of cancer cells, in this study we have investigated...

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Resistance of neuroblastoma GI-ME-N cell line to glutathione depletion involves Nrf2 and heme oxygenase-1

Anna Lisa Furfaro, José Raúl Zumba Macay, Barbara Marengo, Mariapaola Nitti, more

Free Radical Biology and Medicine > 2012 > 52 > 2 > 488-496

Cancer cell survival is known to be related to the ability to counteract oxidative stress, and glutathione (GSH) depletion has been proposed as a mechanism to sensitize cells to anticancer therapy. However, we observed that GI-ME-N cells, a neuroblastoma cell line without MYCN amplification, are able to survive even if GSH-depleted by l-buthionine-(S,R)-sulfoximine (BSO). Here, we show that in GI-ME-N...

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PKC delta and NADPH oxidase in retinoic acid-induced neuroblastoma cell differentiation

Mariapaola Nitti, Anna Lisa Furfaro, Claudia Cevasco, Nicola Traverso, more

Cellular Signalling > 2010 > 22 > 5 > 828-835

The role of reactive oxygen species (ROS) in the regulation of signal transduction processes has been well established in many cell types and recently the fine tuning of redox signalling in neurons received increasing attention. With regard to this, the involvement of NADPH oxidase (NOX) in neuronal pathophysiology has been proposed but deserves more investigation. In the present study, we used SH-SY5Y...

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Heme oxygenase 1 expression in rat liver during ageing and ethanol intoxication

Stefania Patriarca, Anna Lisa Furfaro, Luana Cosso, Elena Pesce Maineri, more

Biogerontology > 2007 > 8 > 3 > 365-372

Heme oxygenase 1 (HO-1) expression is recognized as a marker of cellular response to oxidative stress; since ageing is believed to be related to oxidative “wear and tear”, HO-1 may represent a candidate biomarker of ageing. In our study, the hepatic expression of HO-1 mRNA, evaluated by RT-PCR in 2.5–24 month-old rats, was higher at 6 months than at 2.5 months of age, but thereafter increased no further:...

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Reactive oxygen species: Biological stimuli of neuroblastoma cell response

Barbara Marengo, Lizzia Raffaghello, Vito Pistoia, Damiano Cottalasso, more

Cancer Letters > 2005 > 228 > 1-2 > 111-116

Reactive oxygen species play a critical role in differentiation, proliferation and apoptosis acting as ‘second messengers’ able to regulate sulphydryl groups in signaling molecules as protein kinase C, a family of isoenzymes involved in many cellular responses and implicated in cell transformation. Neuroblastoma is characterised by the production of oxygen intermediates and l-buthionine-S,R-sulfoximine,...

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Anti malondialdehyde-adduct immunological response as a possible marker of successful aging

Nicola Traverso, Stefania Patriarca, Emanuela Balbis, Anna Lisa Furfaro, more

Experimental Gerontology > 2003 > 38 > 10 > 1129-1135

Contrasting results have been obtained by various researchers about oxidative markers of aging. In this study, a healthy over-90-year-old population was examined for various plasma oxidative biomarkers and compared with a healthy population of blood donors (age range 23-66). Plasma malondialdehyde (MDA), evaluated by means of the thiobarbituric acid test, was significantly higher in the over-90-year-old...

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Role of PKC-δ activity in glutathione-depleted neuroblastoma cells

Cinzia Domenicotti, Barbara Marengo, Daniela Verzola, Giacomo Garibotto, more

Free Radical Biology and Medicine > 2003 > 35 > 5 > 504-516

Protein kinases C (PKCs) are a family of isoenzymes sensitive to oxidative modifications and involved in the transduction signal pathways that regulate cell growth. As such, they can act as cellular sensors able to intercept intracellular redox changes and promote the primary adaptive cell response. In this study, we have demonstrated that PKC isoforms are specifically influenced by the amount of...

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Role of PKC-dependent pathways in HNE-induced cell protein transport and secretion

Umberto Maria Marinari, Mariapaola Nitti, Maria Adelaide Pronzato, Cinzia Domenicotti

Molecular Aspects of Medicine > 2003 > 24 > 4-5 > 205-211

The β isoforms of protein Kinase C (PKC) are closely involved in the regulation of cell protein transport and secretion. We have shown in different cellular types that treatment with HNE in a concentration range detectable in many pathophysiological conditions is able to induce selective activation of βPKCs through direct interaction between the aldehyde and these isoenzymes. In isolated rat hepatocytes...

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Oxidative stress induces increase of intracellular a amyloid β-protein and selective activation of PKC βI and βII in NT2 cells

Massimo Tabaton, Dimitri Paola, Roberta Borghi, Antonella Vitali, more

Neurobiology of Aging > 2000 > 21 > Supplement 1 > 41

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Search results for: Umberto Maria Marinari

HO-1 Down-Regulation Increases the Efficacy of BRAFV600E Inhibition-Based Therapy in Primary Melanoma Cells

Neuroblastoma Cell Response to Oxidative Stress Is Impaired by Retinoic Acid-Induced Differentiation: Role of HO-1

A novel mechanism for cyclic adenosine monophosphate–mediated memory formation: Role of amyloid beta

HO-1 up-regulation: A key point in high-risk neuroblastoma resistance to bortezomib

Resistance of neuroblastoma GI-ME-N cell line to glutathione depletion involves Nrf2 and heme oxygenase-1

PKC delta and NADPH oxidase in retinoic acid-induced neuroblastoma cell differentiation

Heme oxygenase 1 expression in rat liver during ageing and ethanol intoxication

Reactive oxygen species: Biological stimuli of neuroblastoma cell response

Anti malondialdehyde-adduct immunological response as a possible marker of successful aging

Role of PKC-δ activity in glutathione-depleted neuroblastoma cells

Role of PKC-dependent pathways in HNE-induced cell protein transport and secretion

Oxidative stress induces increase of intracellular a amyloid β-protein and selective activation of PKC βI and βII in NT2 cells

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