Christopher J. Gilpin

article

Skeletal muscle‐derived exosomes regulate endothelial cell functions via reactive oxygen species‐activated nuclear factor‐κB signalling

Yaohui Nie, Yoriko Sato, Ron T. Garner, Christopher Kargl, more

Experimental Physiology > 104 > 8 > 1262 - 1273

New Findings What is the central question of this study? Capillary rarefaction is found in diabetic and aged muscle, whereas exercise increases skeletal muscle angiogenesis. The association implies a crosstalk between muscle cells and endothelial cells. The underlying mechanisms mediating the crosstalk between these cells remains to be elucidated fully. What is the main finding and its importance?...

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Protein particulate retention and microorganism recovery for rapid detection of Salmonella

Seockmo Ku, Thomas Kreke, Eduardo Ximenes, Kirk Foster, more

Biotechnology Progress > 33 > 3 > 687 - 695

The rapid detection of Salmonella in ground meat requires that living microorganisms be brought to levels detectable by PCR, immunoassays, or similar techniques within 8 h. Previously, we employed microfiltration using hollow fiber membranes to rapidly process and concentrate viable bacteria in food extracts through a combination of enzyme treatment and prefiltration in order to prevent blockage or...

article

Stabilization of immiscible polymer blends using structure directing metal organic frameworks (MOFs)

Nimanka P. Panapitiya, Sumudu N. Wijenayake, Yu Huang, David Bushdiecker, more

Polymer > 2014 > 55 > 8 > 2028-2034

We have developed a novel approach for compatibilizing immiscible polymer blends using metal organic frameworks (MOFs). For the first time we demonstrated that the droplet diameter of the dispersed phase in a 1:1 immiscible polymer blend composed of 6FDA-DAM:DABA [copolymer of 4,4-hexafluoroisopropylidene diphthalic anhydride (6FDA), 2,4,6-trimethyl-1,3-phenylenediamine and 3,5-diaminobenzoic acid...

article

Type III Effector VopC Mediates Invasion for Vibrio Species

Lingling Zhang, Anne Marie Krachler, Christopher A. Broberg, Yan Li, more

Cell Reports > 2012 > 1 > 5 > 453-460

Vibrio spp. are associated with infections caused by contaminated food and water. A type III secretion system (T3SS2) is a shared feature of all clinical isolates of V. parahaemolyticus and some V. cholerae strains. Despite its being responsible for enterotoxicity, no molecular mechanism has been determined for the T3SS2-dependent pathogenicity. Here, we show that although Vibrio spp. are typically...

article

RhoA-inhibiting NSAIDs promote axonal myelination after spinal cord injury

Bin Xing, Hui Li, Hongyu Wang, Dhriti Mukhopadhyay, more

Experimental Neurology > 2011 > 231 > 2 > 247-260

Nonsteroidal anti-inflammatory drugs (NSAIDs) are extensively used to relieve pain and inflammation in humans via cyclooxygenase inhibition. Our recent research suggests that certain NSAIDs including ibuprofen suppress intracellular RhoA signal and improve significant axonal growth and functional recovery following axonal injury in the CNS. Several NSAIDs have been shown to reduce generation of amyloid-beta42...

article

Stroboscopic image capture: Reducing the dose per frame by a factor of 30 does not prevent beam-induced specimen movement in paraffin

Dieter Typke, Christopher J. Gilpin, Kenneth H. Downing, Robert M. Glaeser

Ultramicroscopy > 2007 > 107 > 2-3 > 106-115

Beam-induced specimen movement may be the major factor that limits the quality of high-resolution images of organic specimens. One of the possible measures to improve the situation that was proposed by Henderson and Glaeser [Ultramicroscopy 16 (1985) 139–150], which we refer to here as “stroboscopic image capture”, is to divide the normal exposure into many successive frames, thus reducing the amount...

article

SNARE-Mediated Lipid Mixing Depends on the Physical State of the Vesicles

Xiaocheng Chen, Demet Araç, Tzu-Ming Wang, Christopher J. Gilpin, more

Biophysical Journal > 2006 > 90 > 6 > 2062-2074

Reconstitution experiments have suggested that N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) proteins constitute a minimal membrane fusion machinery but have yielded contradictory results, and it is unclear whether the mechanism of membrane merger is related to the stalk mechanism that underlies physiological membrane fusion. Here we show that reconstitution of solubilized...

article

The application of the environmental scanning electron microscope in biological and materials sciences

Christopher J. Gilpin

Biology of the Cell > 1998 > 90 > 3 > 249

The environmental scanning electron microscope (ESEM) utilises a secondary electron detector capable of operating at pressures in the range of 1 20 Torr (130 2700 Pascals). By use of differential pumping apertures the electron gun and column can be maintained at ''normal'' vacuum levels of 10-5 Torr. A pressure of 10-2 Torr exists within the secondary electron detector separated from the specimen...

INFONA - science communication portal

Search results for: Christopher J. Gilpin

Skeletal muscle‐derived exosomes regulate endothelial cell functions via reactive oxygen species‐activated nuclear factor‐κB signalling

Protein particulate retention and microorganism recovery for rapid detection of Salmonella

Stabilization of immiscible polymer blends using structure directing metal organic frameworks (MOFs)

Type III Effector VopC Mediates Invasion for Vibrio Species

RhoA-inhibiting NSAIDs promote axonal myelination after spinal cord injury

Stroboscopic image capture: Reducing the dose per frame by a factor of 30 does not prevent beam-induced specimen movement in paraffin

SNARE-Mediated Lipid Mixing Depends on the Physical State of the Vesicles

The application of the environmental scanning electron microscope in biological and materials sciences

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