Search results for: Marian Klinger

Items from 1 to 20 out of 44 results

article

Post-transplant Alternative Complement Pathway Activation Influences Kidney Allograft Function

Dorota Bartoszek, Oktawia Mazanowska, Katarzyna Kościelska-Kasprzak, Agnieszka Lepiesza, more

Archivum Immunologiae et Therapiae Experimentalis > 2019 > 67 > 3 > 171-177

The complement system is one of the crucial pathophysiological mechanisms that directly influence the function of a transplanted kidney. Since the complement pathways’ activation potential can be easily determined via their functional activity measurement, we focused on fluctuation in the cascade activity in the early post-transplant period. The aim of the study was to relate the kidney transplantation-induced...

article

Autologous peripheral blood stem cell transplantation in dialysis‐dependent multiple myeloma patients—DAUTOS Study of the Polish Myeloma Study Group

Anna Waszczuk‐Gajda, Zbigniew Lewandowski, Joanna Drozd‐Sokołowska, Piotr Boguradzki, more

European Journal of Haematology > 101 > 4 > 475 - 485

Introduction Dialysis‐dependent (DD) multiple myeloma patients (MM) have a poor prognosis and high tumour burden, thus may benefit from autologous peripheral blood stem cell transplantation (auto‐PBSCT), however, these patients have an increased risk of toxicity. Aims To evaluate the outcomes (toxicity, PFS, OS) of high dose therapy followed by auto‐PBSCT during an observational study and after...

article

Stem cell mobilization in patients with dialysis‐dependent multiple myeloma: Report of the Polish Myeloma Study Group

Anna Waszczuk‐Gajda, Joanna Drozd‐Sokołowska, Piotr Boguradzki, Jarosław Dybko, more

Journal of Clinical Apheresis > 33 > 3 > 249 - 258

Introduction High‐dose chemotherapy with autologous hematopoietic stem cell transplantation (auto‐HSCT) improves the outcome of patients with multiple myeloma (MM). It seems that auto‐HSCT is also a feasible therapeutic option in MM dialysis‐dependent (MMDD) patients. However, to perform transplantation, a sufficient number of stem cells must be collected. Materials and Methods Given that data...

article

Stepwise Attempts on the Forearm Protect Against Exhaustion of Vascular Access Options

Krzysztof Letachowicz, Waldemar Letachowicz, Marian Klinger

American Journal of Kidney Diseases > 2018 > 71 > 5 > 758

article

Dialysis-Related Parameters Influence Remodeling in the Venous Part of the Native Arteriovenous Fistula

Tomasz Gołębiowski, Mariusz Kusztal, Krzysztof Letachowicz, Hanna Augustyniak-Bartosik, more

Annals of Vascular Surgery > 2017 > 45 > C > 179-185

The aim of this study was to evaluate the association of hemodynamic parameters related to hemodialysis and antropometric parameters of patients with changes in the venous part of the arteriovenous fistula (AVF) at points of needling.Two hundred forty-two hemodialysis (HD) patients (60.3% men), with median age 65 (interquartile range [IQR] 56–75) years, on HD treatment for a median of 49 (IQR 20–88)...

article

Antibodies against monomeric C-reactive protein – a promising biomarker of lupus nephritis?

Katarzyna Jakuszko, Magdalena Krajewska, Katarzyna Kościelska-Kasprzak, Marta Myszka, more

Clinical Biochemistry > 2017 > 50 > 13-14 > 756-762

A significant incidence of systemic lupus erythematosus (SLE), the severity of lupus nephritis and varying responses to treatment rationalize the search for novel biomarkers of disease activity.The aim of the study was to assess whether antibodies against monomeric C reactive protein (anti-mCRP) are associated with the presence of lupus nephritis, correlate with disease activity, and whether they...

article

Immune activation‐ and regulation‐related patterns in stable hand transplant recipients

Dorota Kamińska, Katarzyna Kościelska‐Kasprzak, Magdalena Krajewska, Adam Chełmoński, more

Transplant International > 30 > 2 > 144 - 152

We assessed cell subsets and expression of a set of genes related to the T‐cell populations in peripheral blood mononuclear cells to elucidate whether immune status of stable hand transplant recipients (HTx) differs from stable kidney transplant recipients (KTx). The study was conducted on five HTx 4.8 ± 1.7 years after transplantation and 30 stable KTx 7.9 ± 2.4 years after transplantation as well...

article

Vascular access should be tailored to the patient

Krzysztof Letachowicz, Przemysław Szyber, Tomasz Gołębiowski, Mariusz Kusztal, more

Seminars in Vascular Surgery > 2016 > 29 > 4 > 146-152

A cornerstone of hemodialysis treatment is the creation of a functional and durable dialysis vascular access. Every patient with chronic kidney disease should have a plan of renal replacement therapy and access site protection. Factors having a crucial impact on vascular access selection include age, comorbidity, vessel quality, prognosis, dialysis urgency, and surgeon’s preferences. Our medical group...

article

Kidney disease in the elderly: biopsy based data from 14 renal centers in Poland

Agnieszka Perkowska-Ptasinska, Dominika Deborska-Materkowska, Artur Bartczak, Tomasz Stompor, more

BMC Nephrology > 2016 > 17 > 1 > 1-9

Background Longer life expectancy is associated with an increasing prevalence of kidney disease. Aging itself may cause renal damage, but the spectrum of kidney disorders that affect elderly patients is diverse. Few studies, mostly form US, Asia and West Europe found differences in the prevalence of some types of kidney diseases between elderly and younger patients based on renal biopsy findings,...

article

Urgent hemodialysis with the use of peripheral veins to avoid catheter insertion

Tomasz Gołębiowski, Krzysztof Letachowicz, Waldemar Letachowicz, Mariusz Kusztal, more

Hemodialysis International > 20 > 4 > E4 - E6

Urgent hemodialysis (HD) in patients with uremia is usually performed using a central vein catheter unless an arteriovenous fistula (AVF) was created in the predialysis period. We present a unique approach, in a patient in whom the first two HD sessions were conducted without implantation of a catheter or AVF. The perfectly developed peripheral veins of a professional bodybuilder served as vascular...

article

Immunosuppression in the elderly renal allograft recipient: a systematic review

Nuria Montero, María José Pérez-Sáez, Julio Pascual, Daniel Abramowicz, more

Transplantation Reviews > 2016 > 30 > 3 > 144-153

The Elderly are the fastest growing part of kidney transplant recipients. The best immunosuppressive strategy is unknown.We performed a systematic search of randomized controlled trials and observational studies focused on safety and efficacy of different immunosuppression strategies in elderly kidney recipients. Data extraction and risk of bias evaluation were systematically performed.Ten studies...

article

Regarding “A randomized controlled trial of interrupted versus continuous suturing techniques for radiocephalic fistulas”

Krzysztof Letachowicz, Mariusz Kusztal, Tomasz Gołębiowski, Waldemar Letachowicz, more

Journal of Vascular Surgery > 2016 > 63 > 6 > 1666

article

Balloon Dilatation for Removal of an Irretrievable Permanent Hemodialysis Catheter: The Safest Approach

Jerzy Garcarek, Tomasz Gołębiowski, Krzysztof Letachowicz, Mariusz Kusztal, more

Artificial Organs > 40 > 5 > E84 - E88

Long‐term hemodialysis catheter dwell time in the central vein predisposes to fibrin sheath development, which subsequently causes catheter malfunction or occlusion. In very rare cases, the catheter can be overgrown with fibrin and rigidly connected with the vein or heart structures. This makes its removal almost impossible and dangerous because of the possibility of serious complications, namely...

article

CD4⁺CD25⁺CD127⁻ and CD4⁺CD25⁺Foxp3⁺ Regulatory T Cell Subsets in Mediating Autoimmune Reactivity in Systemic Lupus Erythematosus Patients

Marcelina Żabińska, Magdalena Krajewska, Katarzyna Kościelska-Kasprzak, Katarzyna Jakuszko, more

Archivum Immunologiae et Therapiae Experimentalis > 2016 > 64 > 5 > 399-407

The available clinical as well as experimental studies implicate participation of T regulatory (Treg) subsets in the pathogenesis and course of systemic lupus erythematosus (SLE). Introduction of the CD4⁺CD25⁺CD127⁻ and CD4⁺CD25⁺Foxp3⁺ regulatory subpopulations analysis into immunological processes assessment and disease activation prognosis in patients with lupus nephritis (LN) may improve monitoring...

article

Increased Granulocyte Heparanase Activity in Neutrophils from Patients with Lupus Nephritis and Idiopathic Membranous Nephropathy

Maciej Szymczak, Jakub Kuźniar, Wacław Kopeć, Marcelina Żabińska, more

Archivum Immunologiae et Therapiae Experimentalis > 2017 > 65 > 1 > 83-91

Heparanase is a β-glucuronidase that cleaves sugar chains of heparan sulfate proteoglycans. It is believed that heparanase may be involved in the pathogenesis of proteinuria. The aim of this study was to assess the significance of heparanase in the pathogenesis of particular glomerulonephritis types. The evaluation of heparanase activity in serum, urine, and granulocytes and superoxide dismutase (SOD)...

article

The possibility of renal function recovery in chronic hemodialysis patients should not be overlooked: Single center experience

Krzysztof Letachowicz, Katarzyna Madziarska, Waldemar Letachowicz, Magdalena Krajewska, more

Hemodialysis International > 20 > 2 > E12 - E14

Chronic hemodialysis is implemented when irreversible loss of kidney function occurs. Sometimes renal recovery is overlooked. From January 2005 to December 2014, we identified 28 patients hemodialyzed for more than 3 months who had renal replacement therapy discontinued. The group consisted of 17 (57.7%) males and 11 (42.3%) females. Patients were 18–87 years old. Time of hemodialysis ranged from...

article

The snuffbox fistula should be preferred over the wrist arteriovenous fistula

Krzysztof Letachowicz, Tomasz Gołębiowski, Mariusz Kusztal, Waldemar Letachowicz, more

Journal of Vascular Surgery > 2016 > 63 > 2 > 436-440

The snuffbox arteriovenous fistula (SBAVF) is the most distal native vascular access. Although published data show a favorable outcome, the SBAVF is not strongly recommended by the guidelines. The present study compared the patency of SBAVFs and wrist AVFs (WAVFs).All 416 AVFs created by the same nephrologist from March 2006 to October 2014 were reviewed. From 416 procedures, 47 SBAVFs and 77 WAVFs...

article

Single‐lumen tunneled catheter: An old but useful option

Krzysztof Letachowicz, Tomasz Gołębiowski, Mariusz Kusztal, Waldemar Letachowicz, more

Hemodialysis International > 19 > 4 > E21 - E23

We report a case of long‐term uneventful catheter use in a patient with previous recurrent vascular access dysfunction and infection. A single‐lumen tunneled catheter was inserted into the left internal jugular vein after a failed attempt of dual‐lumen permanent catheter placement. The follow‐up since device implantation has exceeded 5 years without any complications related to vascular access.

article

Use of the subcutaneous venous network of the forearm to create an arteriovenous fistula

Tomasz Gołębiowski, Krzysztof Letachowicz, Waldemar Letachowicz, Mariusz Kusztal, more

Hemodialysis International > 19 > 4 > E24 - E28

The reconstruction of vascular access in patients with kidney allograft failure is a challenging problem. A case of a 62‐year‐old man with transplanted kidney insufficiency is described. The patient was initially dialyzed with a wrist radial‐cephalic arteriovenous fistula. In the post‐transplantation period, the enormously dilated venous part of the anastomosis was ligated and the part of the vein...

article

Immunological characteristics of the elderly allograft recipient

Marian Klinger, Miroslaw Banasik

Transplantation Reviews > 2015 > 29 > 4 > 219-223

The increasing number of elderly people with a demand for organ transplantation poses an important medical challenge. The effect of aging on the immune system concerns wide modifications with a considerable influence on transplant outcomes. Aging causes significant changes in immune cells repertoire. Thymic involution impairs the production of new naïve cells. Immune remodeling induces important alterations...

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INFONA - science communication portal

Search results for: Marian Klinger

Post-transplant Alternative Complement Pathway Activation Influences Kidney Allograft Function

Autologous peripheral blood stem cell transplantation in dialysis‐dependent multiple myeloma patients—DAUTOS Study of the Polish Myeloma Study Group

Stem cell mobilization in patients with dialysis‐dependent multiple myeloma: Report of the Polish Myeloma Study Group

Stepwise Attempts on the Forearm Protect Against Exhaustion of Vascular Access Options

Dialysis-Related Parameters Influence Remodeling in the Venous Part of the Native Arteriovenous Fistula

Antibodies against monomeric C-reactive protein – a promising biomarker of lupus nephritis?

Immune activation‐ and regulation‐related patterns in stable hand transplant recipients

Vascular access should be tailored to the patient

Kidney disease in the elderly: biopsy based data from 14 renal centers in Poland

Urgent hemodialysis with the use of peripheral veins to avoid catheter insertion

Immunosuppression in the elderly renal allograft recipient: a systematic review

Regarding “A randomized controlled trial of interrupted versus continuous suturing techniques for radiocephalic fistulas”

Balloon Dilatation for Removal of an Irretrievable Permanent Hemodialysis Catheter: The Safest Approach

CD4⁺CD25⁺CD127⁻ and CD4⁺CD25⁺Foxp3⁺ Regulatory T Cell Subsets in Mediating Autoimmune Reactivity in Systemic Lupus Erythematosus Patients

Increased Granulocyte Heparanase Activity in Neutrophils from Patients with Lupus Nephritis and Idiopathic Membranous Nephropathy

The possibility of renal function recovery in chronic hemodialysis patients should not be overlooked: Single center experience

The snuffbox fistula should be preferred over the wrist arteriovenous fistula

Single‐lumen tunneled catheter: An old but useful option

Use of the subcutaneous venous network of the forearm to create an arteriovenous fistula

Immunological characteristics of the elderly allograft recipient

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