Search results for: Marcin Wierzchowski

Items from 1 to 20 out of 20 results

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An approach for electrochemical functionalization of carbon nanotubes/1-amino-9,10-anthraquinone electrode with catechol derivatives for the development of NADH sensors

Tomasz Rębiś, Agnieszka Sobczak, Marcin Wierzchowski, Agata Frankiewicz, more

Electrochimica Acta > 2018 > 260 > C > 703-715

A new type of modified electrode, consisting of electro generated quinone redox mediator and carbon nanotubes (CNT) for electrocatalytic oxidation of reduced form of β-nicotinamide adenine dinucleotide (NADH) has been developed. The CNT functionalized with 1-amino-9,10-anthraquinone electrodes (GC/CNT/AAQ) were subjected to cyclic voltammetry in the presence of selected 1,2-dihydroxybenzene derivatives...

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Evaluation of the effect of the new methoxy-stilbenes on expression of receptors and enzymes involved in estrogen synthesis in cancer breast cells

Barbara Licznerska, Hanna Szaefer, Marcin Wierzchowski, Renata Mikstacka, more

Molecular and Cellular Biochemistry > 2018 > 444 > 1-2 > 53-62

Our previous study showed that the new synthetic methoxy-stilbenes, 3,4,2′-trimethoxy-trans-stilbene (3MS), 3,4,2′,4′-tetramethoxy-trans-stilbene (4MS), and 3,4,2′,4′,6′-pentamethoxy-trans-stilbene (5MS), modulate the constitutive expression of enzymes and receptors involved in estrogen metabolism in breast immortalized epithelial MCF10 cells. In this study, we evaluated the effect of 3MS, 4MS, and...

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Synthesis, biological evaluation and docking studies of trans‐stilbene methylthio derivatives as cytochromes P450 family 1 inhibitors

Marcin Wierzchowski, Zbigniew Dutkiewicz, Agnieszka Gielara‐Korzańska, Artur Korzański, more

Chemical Biology & Drug Design > 90 > 6 > 1226 - 1236

Cytochromes P450 family 1 (CYP1) are responsible for the metabolism of procarcinogens, for example polycyclic aromatic hydrocarbons and aromatic and heterocyclic amines. The inhibition of CYP1 activity is examined in terms of chemoprevention and cancer chemotherapy. We designed and synthesized a series of trans‐stilbene derivatives possessing a combination of methoxy and methylthio functional groups...

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Development and validation of HPLC–MS/MS procedure for determination of 3,4,4′,5-tetra-methoxystilbene (DMU-212) and its metabolites in ovarian cancer cells and culture medium

Agnieszka Klupczynska, Anna Maria Sulej-Suchomska, Hanna Piotrowska-Kempisty, Marcin Wierzchowski, more

Journal of Chromatography B > 2017 > 1060 > C > 30-35

The synthetic resveratrol analogue DMU-212 (3,4,4′,5-tetramethoxystilbene) has been shown to possess stronger anticancer activity than resveratrol in a variety of tumour cells. To date, there has been no appropriate procedure that would ensure a reliable data about levels of metabolic products of DMU-212 in cancer cell lines. The purpose of this study was to develop a new procedure for determination...

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Role of CYP1A1 in the biological activity of methylated resveratrol analogue, 3,4,5,4′-tetramethoxystilbene (DMU-212) in ovarian cancer A-2780 and non-cancerous HOSE cells

Hanna Piotrowska-Kempisty, Agnieszka Klupczyńska, Dorota Trzybulska, Katarzyna Kulcenty, more

Toxicology Letters > 2017 > 267 > C > 59-66

The role of CYP1A1 and CYP1B1 enzymes in the biotransformation and biological activity of the methylated resveratrol analogue, 3,4,5,4′-tetramethoxystilbene (DMU-212) is still elusive. Our recently published data have shown that one of the metabolites of DMU-212, 3′-hydroxy-3,4,5,4′-tetramethoxystilbene (DMU-214) exerts more potent cytotoxic effects in A-2780 ovarian cancer cell line, as compared...

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Resveratrol and its methoxy derivatives modulate the expression of estrogen metabolism enzymes in breast epithelial cells by AhR down-regulation

Barbara Licznerska, Hanna Szaefer, Marcin Wierzchowski, Hanna Sobierajska, more

Molecular and Cellular Biochemistry > 2017 > 425 > 1-2 > 169-179

Our earlier studies have shown that compared to resveratrol, its analogs with ortho-methoxy substituents exert stronger antiproliferative and proapoptotic activity. Since estrogens are considered the major risk factors of breast carcinogenesis, the aim of this study was to evaluate the effect of 3,4,2′-trimethoxy (3MS), 3,4,2′,4′-tetramethoxy (4MS), and 3,4,2′,4′,6′-pentamethoxy (5MS) trans-stilbenes...

article

O przemieniającym życie mroku postaci

MARCIN WIERZCHOWSKI

Images. The International Journal of European Film, Performing Arts and... > 2016 > 19 > 28 > 47-60

On the darkness of the character that transforms lifeThe author analyses the relationship between the actor>s life and the character they create on stage. He points to the interdependencies between the actor and their role. He determines the conditions in which the role should be constructed and also discusses the on- and off-stage circumstances that determine the value of a particular role. This...

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Photochemical studies and nanomolar photodynamic activities of phthalocyanines functionalized with 1,4,7-trioxanonyl moieties at their non-peripheral positions

Lukasz Sobotta, Marcin Wierzchowski, Michal Mierzwicki, Zofia Gdaniec, more

Journal of Inorganic Biochemistry > 2016 > 155 > C > 76-81

Manganese(III), cobalt(II), copper(II), magnesium(II), zinc(II) and metal-free phthalocyanines, possessing 1,4,7-trioxanonyl substituents, at their non-peripheral positions, were subjected to photochemical, photodynamic and biological activity studies. Demetallated phthalocyanine and its metallated d-block analogues, with copper(II), cobalt(II), manganese(III) chloride, were found to be less efficient...

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DMU-212 inhibits tumor growth in xenograft model of human ovarian cancer

Hanna Piotrowska, Krzysztof Myszkowski, Joanna Abraszek, Eliza Kwiatkowska-Borowczyk, more

Biomedicine & Pharmacotherapy > 2014 > 68 > 4 > 397-400

DMU-212 has been shown to evoke a mitochondrial apoptotic pathway in transformed fibroblasts and breast cancer. However, recently published data indicated the ability of DMU-212 to evoke apoptosis in both mitochondria- and receptor-mediated manner in two ovarian cancer cell lines, namely A-2780 and SKOV-3, which showed varied sensitivity to the compound tested. The pronounced cytotoxic effects of...

article

Prooxidative potential of hydroxylated resveratrol analogs

Malgorzata Kucinska, Hanna Piotrowska, Michał W. Luczak, Justyna Mikula-Pietrasik, more

Chemico-Biological Interactions > 2014 > 209 > Complete > 96-110

Resveratrol and its higher hydroxylated analogs have been reported to possess a variety of biological properties including antioxidant as well as prooxidant effects. The antioxidant properties are assumed to enable these compounds to protect cells from oxidative damage, however prooxidant activity are held likely to be responsible for their cytotoxic or pro-apoptotic effects. In present study the...

article

3,4,5,4′-trans-tetramethoxystilbene (DMU-212) modulates the activation of NF-κB, AP-1, and STAT3 transcription factors in rat liver carcinogenesis induced by initiation-promotion regimen

Michał Cichocki, Wanda Baer-Dubowska, Marcin Wierzchowski, Marek Murias, more

Molecular and Cellular Biochemistry > 2014 > 391 > 1-2 > 27-35

It has been reported that methylated analog of resveratrol, 3,4,5,4′-trans-tetramethoxystilbene (DMU-212), demonstrates strong antiproliferative, and proapoptotic activity. The aim of this study was to evaluate the effect of DMU-212 on the activation of nuclear factor-κB (NF-κB), activator protein-1 (AP-1), and signal transducer and activator of transcription 3 (STAT3) transcription factors, using...

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Different susceptibility of colon cancer DLD-1 and LOVO cell lines to apoptosis induced by DMU-212, a synthetic resveratrol analogue

Hanna Piotrowska, Krzysztof Myszkowski, Ryszard Amarowicz, Marek Murias, more

Toxicology in Vitro > 2013 > 27 > 8 > 2127-2134

The cytotoxic activity of DMU-212 has been shown to vary in cell lines derived from the same type of cancer, i.e. ovarian, breast and colorectal ones. However, the molecular mechanism of DMU-212 cytotoxicity has not been clarified in colon cancer cells. This study aims to elucidate the mechanism of antitumor effects of DMU-212 in two human colon cancer cell lines, DLD-1 and LOVO. We showed the stronger...

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Phthalocyanines functionalized with 2-methyl-5-nitro-1H-imidazolylethoxy and 1,4,7-trioxanonyl moieties and the effect of metronidazole substitution on photocytotoxicity

Marcin Wierzchowski, Lukasz Sobotta, Paulina Skupin-Mrugalska, Justyna Kruk, more

Journal of Inorganic Biochemistry > 2013 > 127 > Complete > 62-72

Four novel magnesium(II) and zinc(II) phthalocyanines bearing 1,4,7-trioxanonyl, polyether and/or (2-methyl-5-nitro-1H-imidazol-1-yl)ethoxy, heterocyclic substituents at their non-peripheral positions were synthesized and assessed in terms of physicochemical and biological properties. Magnesium phthalocyanine derivatives bearing polyether substituents (Pc-1), a mixed system of polyether and heterocyclic...

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Functional singlet oxygen generators based on porphyrazines with peripheral 2,5-dimethylpyrrol-1-yl and dimethylamino groups

Lukasz Sobotta, Piotr Fita, Wojciech Szczolko, Maciej Wrotynski, more

Journal of Photochemistry & Photobiology, A: Chemistry > 2013 > 269 > Complete > 9-16

Photochemical, photophysical and spectral properties of three synthesized porphyrazines, with 2,5-dimethylpyrrol-1-yl and dimethylamino substituents were studied to test their potential usefulness in photodynamic therapy. The porphyrazines are metallated at the core with Mg(II) – MgPz and Zn(II) – ZnPz ions; the third one was in demetallated form (2HPz). The compounds were irradiated with a xenon...

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Synthesis, characterization, photochemical properties and cytotoxicity of the novel porphyrazine functionalized with nitroimidazolylbutylsulfanyl groups

Sebastian Lijewski, Jaroslaw Piskorz, Malgorzata Kucinska, Marcin Wierzchowski, more

Inorganic Chemistry Communications > 2013 > 29 > Complete > 97-100

A novel porphyrazine analog possessing nitroimidazolylbutylsulfanyl groups was synthesized and characterized using UV–Vis, IR, MS MALDI and various NMR techniques. In addition, a computational model following the Density Functional Theory method (DFT) was applied to analyze the FT IR spectrum. Potential photosensitizing activity of the novel porphyrazine was evaluated by measuring its ability to generate...

article

Resveratrol analogue 3,4,4′,5-tetramethoxystilbene inhibits growth, arrests cell cycle and induces apoptosis in ovarian SKOV‐3 and A-2780 cancer cells

Hanna Piotrowska, Krzysztof Myszkowski, Alicja Ziółkowska, Katarzyna Kulcenty, more

Toxicology and Applied Pharmacology > 2012 > 263 > 1 > 53-60

In the screening studies, cytotoxicity of 12 methylated resveratrol analogues on 11 human cancer cell lines was examined. The most active compound 3,4,4′5-tetramethoxystilbene (DMU-212) and two ovarian cancer cell lines A-2780 (IC ₅₀ =0.71μM) and SKOV-3 (IC ₅₀ =11.51μM) were selected for further investigation.To determine the mechanism of DMU-212 cytotoxicity, its ability to induce...

article

Synthesis, characteristics and photochemical studies of novel porphyrazines possessing peripheral 2,5-dimethylpyrrol-1-yl and dimethylamino groups

Wojciech Szczolko, Lukasz Sobotta, Piotr Fita, Tomasz Koczorowski, more

Tetrahedron Letters > 2012 > 53 > 16 > 2040-2044

The synthesis and physicochemical properties of novel porphyrazines possessing an alternate system of two peripheral substituents, 2,5-dimethylpyrrol-1-yl and dimethylamino, are presented. All the macrocycles were subjected to HPLC purity studies. Spectroscopic studies of magnesium(II) porphyrazine encompassed steady state absorption, emission measurements, including fluorescence decays, transient...

article

Femtosecond studies of the excited-state dynamics of ester-alkyloxy substituted zinc phthalocyanines

Piotr Fita, Tomasz Osmalek, Tomasz Goslinski, Marcin Wierzchowski, more

Journal of Photochemistry & Photobiology, A: Chemistry > 2012 > 232 > Complete > 44-49

The ultrafast dynamics of two zinc(II) phthalocyanine derivatives with potential applications in photodynamic therapy was studied by femtosecond transient absorption spectroscopy. The kinetic features of the compounds were determined at excitation wavelengths within the Soret and the Q-bands. Three time constants revealed in time-resolved data were identified with the processes of solvent relaxation,...

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Resveratrol and its synthetic derivatives exert opposite effects on mesothelial cell-dependent angiogenesis via modulating secretion of VEGF and IL-8/CXCL8

Justyna Mikuła-Pietrasik, Angelika Kuczmarska, Małgorzata Kucińska, Marek Murias, more

Angiogenesis > 2012 > 15 > 3 > 361-376

We examined the effect of resveratrol (RVT) and its two derivatives (3,3′,4,4′-tetrahydroxy-trans-stilbene and 3,3′,4,4′,5,5′-hexahydroxy-trans-stilbene) on human peritoneal mesothelial cell (HPMC)-dependent angiogenesis in vitro. To this end, angiogenic activity of endothelial cells (HUVEC, HMVEC, and HMEC-1) was monitored upon their exposure to conditioned medium (CM) from young and senescent HPMCs...

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Photophysical properties and photocytotoxicity of novel phthalocyanines – potentially useful for their application in photodynamic therapy

Tomasz Goslinski, Tomasz Osmalek, Krystyna Konopka, Marcin Wierzchowski, more

Polyhedron > 2011 > 30 > 9 > 1538-1546

Two novel zinc(II) phthalocyanines bearing non-peripheral ester-alkyloxy substituents (Pc-4 and Pc-5) were synthesized, by a two-step procedure starting from 2,3-dicyanohydroquinone. Both sensitizers show promising photophysical properties, including solvatochromic study, qualitative evaluation of emission, aggregation behavior and singlet oxygen generation. It was proven that the photodynamic activity...

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