Search results for: Katia Georgopoulos

Items from 1 to 20 out of 30 results

article

Central role for ikaros in pre-B cell differentiation and pathogenesis of high-risk B-cell acute lymphoblastic leukemia

Richard Van Etten, Yeguang Hu, Zihong Zhang, Toshimi Yoshida, more

Experimental Hematology > 2016 > 44 > 9(S) > S31

article

The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis

Pablo Gómez-del Arco, Eusebio Perdiguero, Paula Sofia Yunes-Leites, Rebeca Acín-Pérez, more

Cell Metabolism > 2016 > 23 > 5 > 881-892

Heart muscle maintains blood circulation, while skeletal muscle powers skeletal movement. Despite having similar myofibrilar sarcomeric structures, these striated muscles differentially express specific sarcomere components to meet their distinct contractile requirements. The mechanism responsible is still unclear. We show here that preservation of the identity of the two striated muscle types depends...

chapter

The Role of the Ikaros Gene Family in Lymphocyte Development

Pablo Gómez-del Arco, Taku Naito, John Seavitt, Toshimi Yoshida, more

Molecular Biology Intelligence Unit > Zinc Finger Proteins > Biology of Zinc Finger Proteins > 200-206

In many developmental systems, nuclear regulators have been implicated in coupling key events in gene expression with specific cell fate and lineage decisions. In the hemo-lymphoid system, the Ikaros gene family of zinc finger DNA binding factors controls lymphocyte specification and homeostasis from the hemopoietic stem cell (HSC) throughout development. The dependence of hemo-lymphoid differentiation...

article

Promoter Decommissioning by the NuRD Chromatin Remodeling Complex Triggers Synaptic Connectivity in the Mammalian Brain

Tomoko Yamada, Yue Yang, Martin Hemberg, Toshimi Yoshida, more

Neuron > 2014 > 83 > 1 > 122-134

Precise control of gene expression plays fundamental roles in brain development, but the roles of chromatin regulators in neuronal connectivity have remained poorly understood. We report that depletion of the NuRD complex by in vivo RNAi and conditional knockout of the core NuRD subunit Chd4 profoundly impairs the establishment of granule neuron parallel fiber/Purkinje cell synapses in the rodent...

article

Ikaros fingers on lymphocyte differentiation

Toshimi Yoshida, Katia Georgopoulos

International Journal of Hematology > 2014 > 100 > 3 > 220-229

The Ikaros family of DNA-binding proteins are critical regulators of lymphocyte differentiation. In multipotent, hematopoietic progenitors, Ikaros supports transcriptional priming of genes promoting lymphocyte differentiation. Ikaros targets the Nucleosome Remodeling Deacetylase (NuRD) complex to lymphoid lineage genes, thereby increasing chromatin accessibility and transcriptional priming. After...

article

A pair of transmembrane receptors essential for the retention and pigmentation of hair

Rong Han, Hideyuki Beppu, Yun‐Kyoung Lee, Katia Georgopoulos, more

genesis > 50 > 11 > 783 - 800

Hair follicles are simple, accessible models for many developmental processes. Here, using mutant mice, we show that Bmpr2, a known receptor for bone morphogenetic proteins (Bmps), and Acvr2a, a known receptor for Bmps and activins, are individually redundant but together essential for multiple follicular traits. When Bmpr2/Acvr2a function is reduced in cutaneous epithelium, hair follicles undergo...

article

Alternative Promoter Usage at the Notch1 Locus Supports Ligand-Independent Signaling in T Cell Development and Leukemogenesis

Pablo Gómez-del Arco, Mariko Kashiwagi, Audrey F. Jackson, Taku Naito, more

Immunity > 2010 > 33 > 5 > 685-698

Loss of the transcription factor Ikaros is correlated with Notch receptor activation in T cell acute lymphoblastic leukemia (T-ALL). However, the mechanism remains unknown. We identified promoters in Notch1 that drove the expression of Notch1 proteins in the absence of a ligand. Ikaros bound to both canonical and alternative Notch1 promoters and its loss increased permissive chromatin, facilitating...

article

Awakening lineage potential by Ikaros-mediated transcriptional priming

Toshimi Yoshida, Samuel Yao-Ming Ng, Katia Georgopoulos

Current Opinion in Immunology > 2010 > 22 > 2 > 154-160

Bioinformatic studies on a revised hierarchy of hematopoietic progenitors have provided a genome-wide view of lineage-affiliated transcriptional programs directing early hematopoiesis. Unexpectedly, lymphoid, myeloid, and erythroid gene expression programs were primed with similar frequency at the multipotent progenitor stage indicating a stochastic nature to this process. Multilineage transcriptional...

article

Ikaros‐1 couples cell cycle arrest of late striatal precursors with neurogenesis of enkephalinergic neurons

Raquel Martín‐Ibáñez, Empar Crespo, Noelia Urbán, Solène Sergent‐Tanguy, more

Journal of Comparative Neurology > 518 > 3 > 329 - 351

During central nervous system development, several transcription factors regulate the differentiation of progenitor cells to postmitotic neurons. Here we describe a novel role for Ikaros‐1 in the generation of late‐born striatal neurons. Our results show that Ikaros‐1 is expressed in the boundary of the striatal germinal zone (GZ)/mantle zone (MZ), where it induces cell cycle arrest of neural progenitors...

article

Genome-wide Lineage-Specific Transcriptional Networks Underscore Ikaros-Dependent Lymphoid Priming in Hematopoietic Stem Cells

Samuel Yao-Ming Ng, Toshimi Yoshida, Jiangwen Zhang, Katia Georgopoulos

Immunity > 2009 > 30 > 4 > 493-507

The mechanisms regulating lineage potential during early hematopoiesis were investigated. First, a cascade of lineage-affiliated gene expression signatures, primed in hematopoietic stem cells (HSCs) and differentially propagated in lineage-restricted progenitors, was identified. Lymphoid transcripts were primed as early as the HSC, together with myeloid and erythroid transcripts. Although this multilineage priming...

article

Antagonistic Interactions between Ikaros and the Chromatin Remodeler Mi-2β Determine Silencer Activity and Cd4 Gene Expression

Taku Naito, Pablo Gómez-del Arco, Christine J. Williams, Katia Georgopoulos

Immunity > 2007 > 27 > 5 > 723-734

Lineage commitment is induced by changes in gene expression dictated by the intimate interaction between transcription factors and chromatin regulators. Here, we revealed the antagonistic interplay between Ikaros and its associate the chromatin remodeler Mi-2β during T cell development, as exemplified by the regulation of Cd4 expression. Loss of Ikaros or Mi-2β led to activation or repression, respectively,...

article

Ikaros DNA-Binding Proteins as Integral Components of B Cell Developmental-Stage-Specific Regulatory Circuits

Elizabeth C. Thompson, Bradley S. Cobb, Pierangela Sabbattini, Sonja Meixlsperger, more

Immunity > 2007 > 26 > 4 > 533

article

Ikaros and chromatin regulation in early hematopoiesis

Samuel Yao-Ming Ng, Toshimi Yoshida, Katia Georgopoulos

Current Opinion in Immunology > 2007 > 19 > 2 > 116-122

Hematopoiesis is the developmental process by which all blood and immune cells are generated. A decade-old scheme has supported an early and complete separation of the erythro-myeloid from the lymphoid lineages. Recent advances have re-drawn this map, separating lymphoid and myeloid from erythroid programs early in development. Subsequently, the fate restriction of both the lympho-myeloid and the...

article

Ikaros DNA-Binding Proteins as Integral Components of B Cell Developmental-Stage-Specific Regulatory Circuits

Elizabeth C. Thompson, Bradley S. Cobb, Pierangela Sabbattini, Sonja Meixlsperger, more

Immunity > 2007 > 26 > 3 > 335-344

Ikaros DNA-binding proteins are critical for the development of lymphocytes and other hematopoietic lineages, but it remains unclear how they cooperate with other regulators of signaling and transcription to achieve ordered gene expression during development. Here, we show that Ikaros proteins regulate the pre-BCR component λ5 in a stage-specific manner. In pre-BI cells, Ikaros modulated λ5 expression...

article

The Chromatin Remodeler Mi-2β Is Required for CD4 Expression and T Cell Development

Christine J. Williams, Taku Naito, Pablo Gómez-del Arco, John R. Seavitt, more

Immunity > 2004 > 20 > 6 > 719-733

Changes in chromatin structure underlie the activation or silencing of genes during development. The chromatin remodeler Mi-2β is highly expressed in thymocytes and is presumed to be a transcriptional repressor because of its presence in the nucleosome remodeling deacetylase (NuRD) complex. Using conditional inactivation, we show that Mi-2β is required at several steps during T cell development: for...

article

The CD8α Gene Locus Is Regulated by the Ikaros Family of Proteins

Nicola Harker, Taku Naito, Marta Cortes, Arnd Hostert, more

Molecular Cell > 2002 > 10 > 6 > 1403-1415

Ikaros family members are important regulatory factors in lymphocyte development. Here we show that Ikaros may play an important role in CD4 versus CD8 lineage commitment decisions by demonstrating: (1) that it binds to regulatory elements in the endogenous CD8α locus in vivo using thymocyte chromatin immunoprecipitations, (2) that Ikaros suppresses position effect variegation of transgenes driven...

article

The Follicular versus Marginal Zone B Lymphocyte Cell Fate Decision Is Regulated by Aiolos, Btk, and CD21

Annaiah Cariappa, Mei Tang, Chuenlei Parng, Eugene Nebelitskiy, more

Immunity > 2001 > 14 > 5 > 603-615

Most splenic B cells in mice that lack Aiolos are mature IgD ^h ⁱ IgM ^l ^o follicular lymphocytes, suggesting that maturation signals delivered via the BCR are enhanced in the absence of Aiolos. The enhanced maturation of follicular B cells is accompanied by the absence of MZ B lymphocytes and the downregulation of CD21 expression in follicular B cells, all of which depend on...

article

Gene regulation and cancer - AACR meeting review, The Homestead, Hot Springs, VA, USA, 14-18 October 1998

Katia Georgopoulos

BBA - Reviews on Cancer > 1999 > 1423 > 3 > R75-R79

article

Control of lymphocyte development by the Ikaros gene family

Marta Cortes, Esther Wong, Joseph Koipally, Katia Georgopoulos

Current Opinion in Immunology > 1999 > 11 > 2 > 167-171

Lymphoid cell differentiation relies on precisely orchestrated gene activation and repression events. Gene targeting studies have demonstrated crucial roles for the transcription factors Ikaros and Aiolos in regulating multiple stages of B and T cell development. Recent experiments suggest that Ikaros and Aiolos set B cell antigen-receptor (BCR)- and TCR-mediated signaling thresholds and that the...

article

Ikaros Sets Thresholds for T Cell Activation and Regulates Chromosome Propagation

Nicole Avitahl, Susan Winandy, Christof Friedrich, Beverly Jones, more

Immunity > 1999 > 10 > 3 > 333-343

T cell activation involves the sustained accumulation of T cell receptor (TCR) and IL-2 receptor (IL-2R) mediated signaling events that promote cell cycle entry and progression. The Ikaros family of nuclear factors regulate this process by providing thresholds overcome by receptor signaling. T cells with reduced levels of Ikaros activity require fewer TCR engagement events for activation, exhibit...

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Search results for: Katia Georgopoulos

Central role for ikaros in pre-B cell differentiation and pathogenesis of high-risk B-cell acute lymphoblastic leukemia

The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis

The Role of the Ikaros Gene Family in Lymphocyte Development

Promoter Decommissioning by the NuRD Chromatin Remodeling Complex Triggers Synaptic Connectivity in the Mammalian Brain

Ikaros fingers on lymphocyte differentiation

A pair of transmembrane receptors essential for the retention and pigmentation of hair

Alternative Promoter Usage at the Notch1 Locus Supports Ligand-Independent Signaling in T Cell Development and Leukemogenesis

Awakening lineage potential by Ikaros-mediated transcriptional priming

Ikaros‐1 couples cell cycle arrest of late striatal precursors with neurogenesis of enkephalinergic neurons

Genome-wide Lineage-Specific Transcriptional Networks Underscore Ikaros-Dependent Lymphoid Priming in Hematopoietic Stem Cells

Antagonistic Interactions between Ikaros and the Chromatin Remodeler Mi-2β Determine Silencer Activity and Cd4 Gene Expression

Ikaros DNA-Binding Proteins as Integral Components of B Cell Developmental-Stage-Specific Regulatory Circuits

Ikaros and chromatin regulation in early hematopoiesis

Ikaros DNA-Binding Proteins as Integral Components of B Cell Developmental-Stage-Specific Regulatory Circuits

The Chromatin Remodeler Mi-2β Is Required for CD4 Expression and T Cell Development

The CD8α Gene Locus Is Regulated by the Ikaros Family of Proteins

The Follicular versus Marginal Zone B Lymphocyte Cell Fate Decision Is Regulated by Aiolos, Btk, and CD21

Gene regulation and cancer - AACR meeting review, The Homestead, Hot Springs, VA, USA, 14-18 October 1998

Control of lymphocyte development by the Ikaros gene family

Ikaros Sets Thresholds for T Cell Activation and Regulates Chromosome Propagation

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