Search results for: Robert D. Miller

Items from 1 to 20 out of 77 results

article

Identification of regenerative processes in neonatal spinal cord injury in the opossum (Monodelphis domestica): A transcriptomic study

Benjamin J. Wheaton, Johnny Sena, Anitha Sundararajan, Pooja Umale, more

Journal of Comparative Neurology > 529 > 5 > 969 - 986

This study investigates the response to spinal cord injury in the gray short‐tailed opossum (Monodelphis domestica). In opossums spinal injury early in development results in spontaneous axon growth through the injury, but this regenerative potential diminishes with maturity until it is lost entirely. The mechanisms underlying this regeneration remain unknown. RNA sequencing was used to identify differential...

chapter

Analysis of tin oxide thin films fabricated via sol-gel and delayed ignition of combustion processes

Andrea Fasoli, Krystelle Lionti, Linda Sundberg, Robert D. Miller, more

2017 ISOCS/IEEE International Symposium on Olfaction and Electronic Nose (ISOEN) > 1 - 3

2017 ISOCS/IEEE International Symposium on Olfaction and Electronic Nose (ISOEN)

Metal oxide semiconductor (MOS) gas sensors based on thin film technology offer the potential of higher sensitivity and faster response and recovery than their thick film counterparts. Solution-based approaches are facile and inexpensive routes to prepare thin films. They also provide the means to control and tune the final MOS morphology. Here we present an analysis of tin oxide-based MOS films tens...

article

On the prenatal initiation of T cell development in the opossum Monodelphis domestica

Victoria L. Hansen, Robert D. Miller

Journal of Anatomy > 230 > 4 > 596 - 600

Thymus‐dependent lymphocytes (T cells) are a critical cell lineage in the adaptive immune system of all jawed vertebrates. In eutherian mammals the initiation of T cell development takes place prenatally and the offspring of many species are born relatively immuno‐competent. Marsupials, in contrast, are born in a comparatively altricial state and with a less well developed immune system. As such,...

article

The UT family of MHC class I loci unique to non-eutherian mammals has limited polymorphism and tissue specific patterns of expression in the opossum

Katina V. Krasnec, Anthony T. Papenfuss, Robert D. Miller

BMC Immunology > 2016 > 17 > 1 > 1-13

Background The Major Histocompatibility Complex (MHC) class I family of genes encode for molecules that have well-conserved structures, but have evolved to perform diverse functions. The availability of the gray, short-tailed opossum, Monodelphis domestica whole genome sequence has allowed for analysis of MHC class I gene content in this marsupial. Utilization of a novel method to search for MHC related...

chapter

Marsupial Immunoglobulin and T Cell Receptor Genomics

Michelle L. Baker, Xinxin Wang, Robert D. Miller

Marsupial Genetics and Genomics > Marsupial Immune Genes > 357-380

The development of marsupial genomic resources has provided a wealth of information for the study of the development and function of the adaptive immune system in these remarkable mammals. Here is reviewed the organization, content, and evolutionary history of the genes encoding the antigen specific receptors of the adaptive immune system, the immunoglobulins and T cell receptors. Included is one...

article

Synthesis of diblock copolymers by combination of organocatalyzed ring‐opening polymerization and atom transfer radical polymerization using trichloroethanol as a bifunctional initiator

Victoria A. Piunova, Hans W. Horn, Gavin O. Jones, Julia E. Rice, more

Journal of Polymer Science Part A: Polymer Chemistry > 54 > 4 > 563 - 569

This study reports an application of trichloroethanol (TCE) as a bifunctional initiator for the synthesis of block copolymers (BCPs) by organocatalyzed ring‐opening polymerization (OROP) and atom transfer radical polymerization (ATRP). TCE was employed to synthesize a low dispersity poly (valerolactone) macroinitiator, which was subsequently used for the ATRP of tert‐butyl methacrylate. While it is...

article

MHC in a monogamous lizard – Characterization of class I MHC genes in the Australian skink Tiliqua rugosa

Talat Hojat Ansari, Terry Bertozzi, Robert D. Miller, Michael G. Gardner

Developmental and Comparative Immunology > 2015 > 53 > 2 > 320-327

The major histocompatibility complex (MHC) is a highly variable region of vertebrate genomes that encodes cellular proteins involved in the immune response. In addition to the benefits of MHC research in understanding the genetic basis of host resistance to disease, the MHC is an ideal candidate for studying genetic diversity under strong natural selection. However, the MHC of many non-model vertebrate...

article

Water soluble, biodegradable amphiphilic polymeric nanoparticles and the molecular environment of hydrophobic encapsulates: Consistency between simulation and experiment

Robert D. Miller, Rosmadi M. Yusoff, William C. Swope, Julia E. Rice, more

Polymer > 2015 > 79 > C > 255-261

Star polymers with a crosslinked nanogel core constitute an unusual class of polymers with many arms emanating from the functionalized core. Although the core is usually hydrophobic, the arms can be hydrophobic, hydrophilic or amphiphilic. We describe the synthesis of biodegradable nanogel core stars which are largely water soluble and use encapsulated pyrene fluorescence to probe the environment...

article

The opossum MHC genomic region revisited

Katina V. Krasnec, Alana R. Sharp, Tracey L. Williams, Robert D. Miller

Immunogenetics > 2015 > 67 > 4 > 259-264

The gray short-tailed opossum Monodelphis domestica is one of the few marsupial species for which a high quality whole genome sequence is available and the major histocompatibility complex (MHC) region has been annotated. Previous analyses revealed only a single locus within the opossum MHC region, designated Modo-UA1 , with the features expected for encoding a functionally...

article

Marsupials and monotremes possess a novel family of MHC class I genes that is lost from the eutherian lineage

Anthony T Papenfuss, Zhi-Ping Feng, Katina Krasnec, Janine E Deakin, more

BMC Genomics > 2015 > 16 > 1 > 1-13

Background Major histocompatibility complex (MHC) class I genes are found in the genomes of all jawed vertebrates. The evolution of this gene family is closely tied to the evolution of the vertebrate genome. Family members are frequently found in four paralogous regions, which were formed in two rounds of genome duplication in the early vertebrates, but in some species class Is have been subject to...

article

Teaching with Reverence: Reviving an Ancient Virtue for Today's Schools. Edited by A. G.Rud and JimGarrison. New York, N.Y.: Palgrave Macmillan, 2012. xv + 168 pages. ISBN 978‐0‐230‐11492‐0. $85.00.

Robert D. Miller

Teaching Theology & Religion > 17 > 1 > 89 - 90

article

A VpreB3 homologue in a marsupial, the gray short-tailed opossum, Monodelphis domestica

Xinxin Wang, Zuly E. Parra, Robert D. Miller

Immunogenetics > 2012 > 64 > 8 > 647-652

A VpreB surrogate light (SL) chain was identified for the first time in a marsupial, the opossum Monodelphis domestica. Comparing the opossum VpreB to homologues from eutherian (placental mammals) and avian species supported the marsupial gene being VpreB3. VpreB3 is a protein that is not known to traffic to the cell surface as part of the pre-B cell receptor. Rather, VpreB3 associates with nascent...

article

Recombination, transcription, and diversity of a partially germline-joined VH in a mammal

Xinxin Wang, Robert D. Miller

Immunogenetics > 2012 > 64 > 9 > 713-717

Full or partially germline-joined V genes have been described in a number of different vertebrate lineages where they can contribute to the expressed antibody repertoire through different mechanisms. Here we demonstrate that VH3.1, a partially germline-joined VH gene in the opossum Monodelphis domestica, can undergo V(D)J recombination to generate productive IgH transcripts. VH3.1 is fused to a DH...

article

Comparative analysis of the chicken TCRα/δ locus

Zuly E. Parra, Robert D. Miller

Immunogenetics > 2012 > 64 > 8 > 641-645

The access to whole genome sequences has provided the opportunity to study the evolution and organization of immunologically related genes on a large scale. The genes encoding the T cell receptor (TCR) α and δ chains are part of a complex locus that has shown remarkable conserved organization across different amniote lineages. In this study we have examined and annotated the TCRα/δ locus in chicken...

article

Development of CAPS and dCAPS markers for CYP82E4, CYP82E5v2 and CYP82E10 gene mutants reducing nicotine to nornicotine conversion in tobacco

Dandan Li, Ramsey S. Lewis, Anne M. Jack, Ralph E. Dewey, more

Molecular Breeding > 2012 > 29 > 3 > 589-599

Nornicotine accumulation in tobacco is of concern because nornicotine is a precursor of N-nitrosonornicotine (NNN), a tobacco constituent recognized as a carcinogen by the health community. Nornicotine is derived from nicotine through a demethylation process catalyzed by nicotine demethylase enzymes. Three genes (CYP82E4, CYP82E5v2, and CYP82E10) have currently been identified that encode for these...

article

Nanogel Star Polymer Architectures: A Nanoparticle Platform for Modular Programmable Macromolecular Self‐Assembly, Intercellular Transport, and Dual‐Mode Cargo Delivery

Victor Y. Lee, Karen Havenstrite, Melia Tjio, Melanie McNeil, more

Advanced Materials > 23 > 39 > 4509 - 4515

Nanogel star polymers are developed as a new route for the formation of dual‐mode nanoparticle systems for applications in the areas of synergistic therapeutic delivery, imaged therapeutic delivery, and dual‐mode bioimaging agents. These extremely uniform, structurally versatile, water‐soluble, unimolecular organic nanoparticles with tunable polyvalency and functionality are preprogrammed to spontaneously...

article

Star Polymer Nanoparticles: Nanogel Star Polymer Architectures: A Nanoparticle Platform for Modular Programmable Macromolecular Self‐Assembly, Intercellular Transport, and Dual‐Mode Cargo Delivery (Adv. Mater. 39/2011)

Victor Y. Lee, Karen Havenstrite, Melia Tjio, Melanie McNeil, more

Advanced Materials > 23 > 39 > 4464 - 4464

On page 4509, Robert D. Miller, Joseph Sly, and co‐workers report the use of sequential polymer synthesis to create highly uniform, size‐controlled nanogel star polymer nanoparticles capable of programmable tandem‐modal self‐assembly with other functional molecules and transportation of their “cargo” across cellular membranes. These dual‐mode unimolecular delivery vehicles have been developed for...

article

Abundant non-toxic materials for thin film solar cells: Alternative to conventional materials

Fahhad Alharbi, John D. Bass, Abdelmajid Salhi, Ahmed Alyamani, more

Renewable Energy > 2011 > 36 > 10 > 2753-2758

Presented are the results of a comparative analysis to identify abundant, non-toxic binary materials with potential applicability for photovoltaics. Materials other than the conventional Si, CdTe, and Cu(In,Ga)Se ₂ (CIGS) are examined. The screening is based on the materials’ bulk properties and a set of environmental, physical, and chemical criteria. The screening process is detailed and...

article

Transcriptomic analysis supports similar functional roles for the two thymuses of the tammar wallaby

Emily Sw Wong, Anthony T Papenfuss, Andreas Heger, Arthur L Hsu, more

BMC Genomics > 2011 > 12 > 1 > 1-12

Background The thymus plays a critical role in the development and maturation of T-cells. Humans have a single thoracic thymus and presence of a second thymus is considered an anomaly. However, many vertebrates have multiple thymuses. The tammar wallaby has two thymuses: a thoracic thymus (typically found in all mammals) and a dominant cervical thymus. Researchers have known about the presence of...

article

An Efficient and Low‐Cost Method for the Purification of Colloidal Nanoparticles

John D. Bass, Xin Ai, Abdulaziz Bagabas, Philip M. Rice, more

Angewandte Chemie > 123 > 29 > 6668 - 6672

In null Komma nichts sauber! Ein skalierbares Verfahren zur Reinigung von Nanopartikeln in nichtwässrigen Medien wurde entwickelt, das auf einer reversiblen elektrophoretischen Abscheidung beruht. Damit werden Nanopartikel unterschiedlicher Größe, Form, Zusammensetzung und Ligandenumgebung in weniger als zwei Minuten auf einer Elektrodenoberfläche abgeschieden, gewaschen und redispergiert.

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INFONA - science communication portal

Search results for: Robert D. Miller

Identification of regenerative processes in neonatal spinal cord injury in the opossum (Monodelphis domestica): A transcriptomic study

Analysis of tin oxide thin films fabricated via sol-gel and delayed ignition of combustion processes

On the prenatal initiation of T cell development in the opossum Monodelphis domestica

The UT family of MHC class I loci unique to non-eutherian mammals has limited polymorphism and tissue specific patterns of expression in the opossum

Marsupial Immunoglobulin and T Cell Receptor Genomics

Synthesis of diblock copolymers by combination of organocatalyzed ring‐opening polymerization and atom transfer radical polymerization using trichloroethanol as a bifunctional initiator

MHC in a monogamous lizard – Characterization of class I MHC genes in the Australian skink Tiliqua rugosa

Water soluble, biodegradable amphiphilic polymeric nanoparticles and the molecular environment of hydrophobic encapsulates: Consistency between simulation and experiment

The opossum MHC genomic region revisited

Marsupials and monotremes possess a novel family of MHC class I genes that is lost from the eutherian lineage

Teaching with Reverence: Reviving an Ancient Virtue for Today's Schools. Edited by A. G.Rud and JimGarrison. New York, N.Y.: Palgrave Macmillan, 2012. xv + 168 pages. ISBN 978‐0‐230‐11492‐0. $85.00.

A VpreB3 homologue in a marsupial, the gray short-tailed opossum, Monodelphis domestica

Recombination, transcription, and diversity of a partially germline-joined VH in a mammal

Comparative analysis of the chicken TCRα/δ locus

Development of CAPS and dCAPS markers for CYP82E4, CYP82E5v2 and CYP82E10 gene mutants reducing nicotine to nornicotine conversion in tobacco

Nanogel Star Polymer Architectures: A Nanoparticle Platform for Modular Programmable Macromolecular Self‐Assembly, Intercellular Transport, and Dual‐Mode Cargo Delivery

Star Polymer Nanoparticles: Nanogel Star Polymer Architectures: A Nanoparticle Platform for Modular Programmable Macromolecular Self‐Assembly, Intercellular Transport, and Dual‐Mode Cargo Delivery (Adv. Mater. 39/2011)

Abundant non-toxic materials for thin film solar cells: Alternative to conventional materials

Transcriptomic analysis supports similar functional roles for the two thymuses of the tammar wallaby

An Efficient and Low‐Cost Method for the Purification of Colloidal Nanoparticles

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