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Conserved molecular patterns derived from pathogenic microorganisms prime antigen-presenting dendritic cells (DC) to induce adaptive T cell responses. In contrast, virus-infected or tumor cells that express low levels of major histocompatibility complex (MHC) class I activate natural killer (NK) cells for direct killing. It is unknown whether NK cell recognition of MHC class I low ...
Organ-specific autoimmune diseases, such as psoriasis, rheumatoid arthritis, multiple sclerosis and autoimmune diabetes, are initiated by aberrant activation of interferon-γ (IFN-γ)-producing T helper 1 (Th1) cells that recognize self-peptides expressed inside these organs. Together, these diseases affect 3-5% of the population. Predisposing factors, such as susceptibility genes and environmental...
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