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We describe a new tandem-columns chiral–achiral HPLC arrangement by using a chiral column (CHIROBIOTIC TAG™) connected in series with an achiral column (Spherisorb S5 SCX), based on a strong cationic exchange mechanism; this approach is very useful for the analysis of chiral molecules, containing cationic groups in their structures. We used this special combination to develop an easy and convenient...
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