Search results for: Christian Bailly

Items from 1 to 20 out of 207 results

article

Limonoids isolated from Chisocheton ceramicus Miq. and the antiadipogenic mechanism of action of ceramicine B

Christian Bailly

Archiv der Pharmazie > 357 > 8 > n/a - n/a

Different types of limonoids have been isolated from plants of the Chisocheton genus, notably from the species Chisocheton ceramicus Miq. which is largely distributed in the Indonesian archipelago and Malaysia region. A variety of natural products have been found in the bark of the tree and characterized as antimicrobial and/or antiproliferative agents. The isolated limonoids include chisomicines...

article

Molecular docking study of GSK‐3β interaction with nomilin, kihadanin B, and related limonoids and triterpenes with a furyl‐δ‐lactone core

Gérard Vergoten, Christian Bailly

Journal of Biochemical and Molecular Toxicology > 36 > 9 > n/a - n/a

Glycogen synthase kinase‐3β (GSK‐3β) is a target enzyme considered for the treatment of multiple human diseases, from neurodegenerative pathologies to viral infections and cancers. Numerous inhibitors of GSK‐3β have been discovered but thus far only a few have reached clinical trials and only one drug, tideglusib (1), has been registered. Natural products targeting GSK‐3β have been identified, including...

article

The health benefits of santol fruits and bioactive products isolated from Sandoricum koetjape Merr.: A scoping review

Christian Bailly

Journal of Food Biochemistry > 46 > 7 > n/a - n/a

The santol tree (Sandoricum koetjape Merr.) is largely distributed in Southeast Asia. It produces useful timber and edible fruits, consumed fresh, and transformed. It has a wide range of traditional medicinal uses for the treatment of inflammatory disorders and digestive troubles. Numerous bioactive natural products have been isolated from the roots, leaves, stems, and fruits of S. koetjape, including...

article

Molecular docking of brazilin and its analogs to barrier‐to‐autointegration factor 1 (BAF1)

Maria de Nazaré Correia Soeiro, Gérard Vergoten, Christian Bailly

Annals of the New York Academy of Sciences > 1511 > 1 > 154 - 163

The tetracyclic phenolic compound brazilin, derived from the wood of Caesalpinia sappan, has been shown to bind to the chromatin protein BAF1 (barrier‐to‐autointegration factor 1), a protein essential to maintain integrity of the nuclear envelope in cells. BAF1 plays a role in cancer development. Using molecular docking, we have located the binding site for brazilin on the surface of the BAF1 monomer...

article

Acankoreagenin and acankoreosides, a family of lupane triterpenoids with anti‐inflammatory properties: an overview

Christian Bailly

Annals of the New York Academy of Sciences > 1502 > 1 > 14 - 27

Acankoreagenin (ACK, also known as acankoreanogenin and HLEDA) and impressic acid are two lupane‐type triterpenes that can be isolated from various Acanthopanax and Schefflera species. They efficiently block activation of the NF‐κB signaling pathway and the release of proinflammatory cytokines and/or the action of inflammation mediators (HMGB1, iNOS, and NO). These effects are the basis for the antiviral...

article

Bio‐Sourced Poly l‐Lactide‐Flax Composites with Close to Maximum Stiffness at Low Fiber Content through Two‐Stage Annealing

Rajendar Nutenki, Pascal Van Velthem, Martial Kuete, Matthieu Lezaak, more

Macromolecular Materials and Engineering > 306 > 10 > n/a - n/a

Poly l‐Lactide (PLLA) composites with short flax fibers (from 0 to 10 wt/wt%) with close to maximum theoretical stiffness are prepared by melt‐compounding and injection‐molding followed by a two‐step isothermal crystallization protocol that fully separates the nucleation and growth stages (Tammann). The use of fast chip scanning calorimetry for thermal characterization avoids the complicating issues...

article

Pyronaridine: An update of its pharmacological activities and mechanisms of action

Christian Bailly

Biopolymers > 112 > 4 > n/a - n/a

Pyronaridine (PYR) is an erythrocytic schizonticide with a potent antimalarial activity against multidrug‐resistant Plasmodium. The drug is used in combination with artesunate for the treatment of uncomplicated P. falciparum malaria, in adults and children. The present review briefly retraces the discovery of PYR and recent antimalarial studies which has led to the approval of PYR/artesunate combination...

article

Anticancer properties and mechanism of action of the quassinoid ailanthone

Christian Bailly

Phytotherapy Research > 34 > 9 > 2203 - 2213

Ailanthone (AIT) is a quassinoid natural product isolated from the worldwide‐distributed plant Ailanthus altissima. The drug displays multiple pharmacological properties, in particular significant antitumor effects against a variety of cancer cell lines in vitro. Potent in vivo activities have been evidenced in mice bearing hepatocellular carcinoma, nonsmall cell lung cancer and castration‐resistant...

article

Flexible twist polarizer based on ultrathin multi‐layered polymer‐carbon nanotubes composite films

Yann Danlée, Isabelle Huynen, Christian Bailly

Microwave and Optical Technology Letters > 59 > 11 > 2844 - 2848

We present an ultrathin and flexible microwave broadband polarization transformer concept based on oriented carbon nanotubes dispersed in a polycarbonate matrix. Stacking anisotropic composite films with a controlled angle mismatch between successive layers produces a twist polarizer able to change the orientation of the electric field over broad frequency range in the microwave domain. The smart...

article

Erratum for: Multilayer cylindrical invisibility cloak at microwave frequencies built from polymer and carbon nanotubes

Yann Danlée, Isabelle Huynen, Christian Bailly

Microwave and Optical Technology Letters > 59 > 5 > 1227 - 1227

article

Flexible polarization‐dependent absorbers based on patterned carbon nanotubes films

Yann Danlée, Christian Bailly, Isabelle Huynen

Microwave and Optical Technology Letters > 59 > 5 > 1164 - 1167

We present a thin and flexible broadband polarizer‐absorber concept based on a multi‐layered anisotropic arrangement of carbon nanotubes (CNT) and polymer films. The anisotropic layers consist of CNT striplines deposited over a prepared polycarbonate surface. Stacks of the patterned composites organized in gradient of layer conductivity are very effective for polarization‐sensitive absorption of incident...

article

Absorption modulation of FSS-polymer nanocomposites through incorporation of conductive nanofillers

Rajkumar Jaiswar, Yann Danlée, Henok Mesfin, Arnaud Delcorte, more

Applied Physics A > 2017 > 123 > 3 > 1-8

The hybrid concept of utilizing frequency selective surface (FSS) and polymer nanocomposite (PNC) for absorption modulation is presented in 8–18 GHz frequency band. The extruded PNCs are fabricated by incorporating different weight% fraction of conductive fillers, namely carbon nanotubes (CNTs) and graphene nanoplatelets (GNPs), in high, low and mixed nano-filler concentration in a polycarbonate matrix...

article

Interdiffusion and phase separation upon curing in thermoset-thermoplastic interphases unravelled by the characterization of partially cured systems

Quentin Voleppe, Thomas Pardoen, Christian Bailly

Polymer > 2016 > 106 > C > 120-127

The evolution upon curing of interdiffusion as well as phase separation is characterized at the interphase between a high T_g poly(ether sulfone) thermoplastic (TP) and a high density thermosetting network (TS), both components being initially miscible. We show that the late stages of the diffusion process overlap with the early stages of phase separation, which is contrary to the expectations from...

article

Synergistic local toughening of high performance epoxy-matrix composites using blended block copolymer-thermoplastic thin films

Amir Bahrami, François Cordenier, Pascal Van Velthem, Wael Ballout, more

Composites Part A: Applied Science and Manufacturing > 2016 > 91 > P1 > 398-405

A new block copolymer-thermoplastic dual toughening concept for high performance RTM6 epoxy matrix composites is elaborated through a comprehensive microstructural study of well-defined model systems. A blend of phenoxy and MAM (copolymer of poly(methyl methacrylate) and poly(butyl acrylate)) increases the toughness of the corresponding carbon fiber reinforced composite by 125%, a five-fold synergistic...

article

Multilayer cylindrical invisibility cloak at microwave frequencies built from polymer and carbon nanotubes

Yann Danlée, Isabelle Huynen, Christian Bailly

Microwave and Optical Technology Letters > 59 > 1 > 65 - 69

We present a multilayered invisibility cloak effective at microwave frequencies based on carbon nanotubes (CNT) and polymer foam. The structure deflects transverse magnetic (TM) waves at 6GHz to reconstruct the incoming wave front beyond an obstacle. This is achieved with the help of nested cylindrical arrangements of anisotropic conductive films and insulating foam spacers, which provide the correct...

article

Quantitative understanding of two distinct melting kinetics of an isothermally crystallized poly(ether ether ketone)

Yoshitomo Furushima, Akihiko Toda, Vincent Rousseaux, Christian Bailly, more

Polymer > 2016 > 99 > C > 97-104

The multiple melting peaks of isothermally crystallized poly(ether ether ketone) were investigated by fast-scanning chip calorimetry over a wide range of heating rates from 500 to 60,000 K s⁻¹. The analysis of heating rate dependence of melting temperatures revealed that there are two crystal populations with distinct melting kinetics for the samples prepared at different crystallization temperatures,...

chapter

Topoisomerase Inhibitors of Marine Origin and Their Potential Use as Anticancer Agents

Nathalie Dias, Hervé Vezin, Amélie Lansiaux, Christian Bailly

Topics in Current Chemistry > DNA Binders and Related Subjects > 89-108

Cancer chemotherapy relies to a great extent on the use of drugs like doxorubicin, etoposide, and camptothecin derivatives, which are targeted at topoisomerases. These enzymes that resolve DNA topological constraints in cells are the primary targets for a large diversity of natural products extracted from plants, microorganisms or, as reviewed here, from marine organisms. Marine products capable of...

article

Thin Oriented Polymer Carbon Nanotube Composites for Microwave Absorption

Henok M. Mesfin, Sophie Hermans, Isabelle Huynen, Arnaud Delcorte, more

Materials Today: Proceedings > 2016 > 3 > 2 > 491-496

This paper presents an approach for electromagnetic shielding by absorption based on polycarbonate films containing oriented carbon nanotubes. Films with and without in plane CNT orientation were obtained by squeezing nanocomposites in the melt. The results reveal that the thick non-oriented and thin oriented nanocomposites have comparable highest electromagnetic absorption around 50% over a broad...

article

F14512, a polyamine-vectorized inhibitor of topoisomerase II, exhibits a marked anti-tumor activity in ovarian cancer

Benoît Thibault, Emily Clement, Grégoire Zorza, Samuel Meignan, more

Cancer Letters > 2016 > 370 > 1 > 10-18

Epithelial ovarian cancer is the fourth cause of death among cancer-bearing women and frequently associated with carboplatin resistance, underlining the need for more efficient and targeted therapies. F14512 is an epipodophylotoxin-core linked to a spermine chain which enters cells via the polyamine transport system (PTS). Here, we investigate this novel concept of vectorization in ovarian cancer...

article

Anticancer activity of koningic acid and semisynthetic derivatives

Nicolas J. Rahier, Nicolas Molinier, Christophe Long, Sunil Kumar Deshmukh, more

Bioorganic & Medicinal Chemistry > 2015 > 23 > 13 > 3712-3721

A screening program aimed at discovering novel anticancer agents based on natural products led to the selection of koningic acid (KA), known as a potent inhibitor of glycolysis. A method was set up to produce this fungal sesquiterpene lactone in large quantities by fermentation, thus allowing (i) an extensive analysis of its anticancer potential in vitro and in vivo and (ii) the semi-synthesis of...

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INFONA - science communication portal

Search results for: Christian Bailly

Limonoids isolated from Chisocheton ceramicus Miq. and the antiadipogenic mechanism of action of ceramicine B

Molecular docking study of GSK‐3β interaction with nomilin, kihadanin B, and related limonoids and triterpenes with a furyl‐δ‐lactone core

The health benefits of santol fruits and bioactive products isolated from Sandoricum koetjape Merr.: A scoping review

Molecular docking of brazilin and its analogs to barrier‐to‐autointegration factor 1 (BAF1)

Acankoreagenin and acankoreosides, a family of lupane triterpenoids with anti‐inflammatory properties: an overview

Bio‐Sourced Poly l‐Lactide‐Flax Composites with Close to Maximum Stiffness at Low Fiber Content through Two‐Stage Annealing

Pyronaridine: An update of its pharmacological activities and mechanisms of action

Anticancer properties and mechanism of action of the quassinoid ailanthone

Flexible twist polarizer based on ultrathin multi‐layered polymer‐carbon nanotubes composite films

Erratum for: Multilayer cylindrical invisibility cloak at microwave frequencies built from polymer and carbon nanotubes

Flexible polarization‐dependent absorbers based on patterned carbon nanotubes films

Absorption modulation of FSS-polymer nanocomposites through incorporation of conductive nanofillers

Interdiffusion and phase separation upon curing in thermoset-thermoplastic interphases unravelled by the characterization of partially cured systems

Synergistic local toughening of high performance epoxy-matrix composites using blended block copolymer-thermoplastic thin films

Multilayer cylindrical invisibility cloak at microwave frequencies built from polymer and carbon nanotubes

Quantitative understanding of two distinct melting kinetics of an isothermally crystallized poly(ether ether ketone)

Topoisomerase Inhibitors of Marine Origin and Their Potential Use as Anticancer Agents

Thin Oriented Polymer Carbon Nanotube Composites for Microwave Absorption

F14512, a polyamine-vectorized inhibitor of topoisomerase II, exhibits a marked anti-tumor activity in ovarian cancer

Anticancer activity of koningic acid and semisynthetic derivatives

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