Prostaglandins (PGs) of the J 2 series form in vivo and exert effects on a variety of biological processes. While most PGs mediate their effects through G protein-coupled receptors, the mechanism of action for the J 2 series of PGs remains unclear. Here, we report that PGJ 2 and its derivatives are efficacious activators of peroxisome proliferator-activated receptors α and...
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