Search results for: Kang Choon Lee

Items from 1 to 20 out of 106 results

article

PEGylated TRAIL ameliorates experimental inflammatory arthritis by regulation of Th17 cells and regulatory T cells

Jong-Sung Park, Yumin Oh, Ogyi Park, Catherine A. Foss, more

Journal of Controlled Release > 2017 > 267 > C > 163-171

TNF-related apoptosis-inducing ligand (TRAIL) is a death ligand that can induce apoptosis in cells expressing its cognate death receptors (DRs). Previously, we demonstrated the therapeutic potential of recombinant human TRAIL in experimental rheumatoid arthritis (RA) models. However, the mechanisms of how DR-mediated apoptosis elicits these actions is not known. Here, we show that systemically administering...

article

The synthesis of tamoxifen-loaded albumin nanoparticles by homogenizers: Optimization and in vitro characterization

Maryam Sadat Safavi, Seyed Abbas Shojaosadati, Farid Abedin Dorkoosh, Hyun Ji Jo, more

Journal of Drug Delivery Science and Technology > 2017 > 41 > Complete > 20-30

The aim of this study was to develop mechanical homogenization processes to fabricate protein-based nanoparticles. The high-pressure homogenizer (HPH) and high-speed homogenizer (HSH); were used to encapsulate the hydrophobic drug, tamoxifen, in albumin nanoparticles. The results revealed that the rotational speed with HSH and the pressure with HPH were the main factors affecting the size, while increasing...

article

Reducing agent-free synthesis of curcumin-loaded albumin nanoparticles by self-assembly at room temperature

Maryam Sadat Safavi, Seyed Abbas Shojaosadati, Hye Gyeong Yang, Yejin Kim, more

International Journal of Pharmaceutics > 2017 > 529 > 1-2 > 303-309

The purpose of this study was to prepare curcumin-loaded bovine serum albumin nanoparticles (CCM-BSA-NPs) by reducing agent-free self-assembly at room temperature. A 2⁴ factorial design approach was used to investigate the CCM-BSA-NP preparation process at different pH values, temperatures, dithiothreitol amounts, and CCM/BSA mass ratios. Increasing the ionic strength enabled preparation of CCM-BSA-NPs...

article

Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells

Yumin Oh, Ogyi Park, Magdalena Swierczewska, James P. Hamilton, more

Hepatology > 64 > 1 > 209 - 223

Liver fibrosis is a common outcome of chronic liver disease that leads to liver cirrhosis and hepatocellular carcinoma. No US Food and Drug Administration–approved targeted antifibrotic therapy exists. Activated hepatic stellate cells (aHSCs) are the major cell types responsible for liver fibrosis; therefore, eradication of aHSCs, while preserving quiescent HSCs and other normal cells, is a logical...

article

Doxorubicin-Bound Albumin Nanoparticles Containing a TRAIL Protein for Targeted Treatment of Colon Cancer

Le Quang Thao, Hyeong Jun Byeon, Changkyu Lee, Seunghyun Lee, more

Pharmaceutical Research > 2016 > 33 > 3 > 615-626

Purpose We developed a new nanoparticle formulation comprised of human serum albumin (HSA) for co-delivery of doxorubicin (Dox) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) with the goal of apoptotic synergy in the treatment of colon cancer. Methods TRAIL (0.2, 0.4, 1.0%)- and Dox-loaded HSA nanoparticles (TRAIL/Dox HSA NPs) were prepared by using the nab^TM technology. Morphological...

article

Delivery of tumor-homing TRAIL sensitizer with long-acting TRAIL as a therapy for TRAIL-resistant tumors

Yumin Oh, Magdalena Swierczewska, Tae Hyung Kim, Sung Mook Lim, more

Journal of Controlled Release > 2015 > 220 > PB > 671-681

Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) has attracted great interest as a cancer therapy because it selectively induces death receptor (DR)-mediated apoptosis in cancer cells while sparing normal tissue. However, recombinant human TRAIL demonstrates limited therapeutic efficacy in clinical trials, possibly due to TRAIL-resistance of primary cancers and its inherent short half-life...

article

Mono-lithocholated exendin-4-loaded glycol chitosan nanoparticles with prolonged antidiabetic effects

Sohee Son, Sung Mook Lim, Su Young Chae, Kwangmeyung Kim, more

International Journal of Pharmaceutics > 2015 > 495 > 1 > 81-86

Hydrophobically modified glycol chitosan (HGC) nanoparticles loaded with mono-lithocholic acid-conjugated exendin-4 at the Lys²⁷ residue (LAM1-Ex4) were prepared and characterized by particle size measurement, proteolytic stability, in vitro drug-release profile, and in vivo antidiabetic effects in a db/db diabetic mouse model. Compared with Ex-4-loaded HGC nanoparticles (Ex4/HGC NPs) prepared as...

article

Facile one-pot formulation of TRAIL-embedded paclitaxel-bound albumin nanoparticles for the treatment of pancreatic cancer

Sun Young Min, Hyeong Jun Byeon, Changkyu Lee, Jisoo Seo, more

International Journal of Pharmaceutics > 2015 > 494 > 1 > 506-515

Nanoparticle albumin-bound (nab™) technology is an effective way of delivering hydrophobic chemotherapeutics. We developed a one-pot/one-step formulation of paclitaxel (PTX)-bound albumin nanoparticles with embedded tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/PTX HSA-NP) for the treatment of pancreatic cancer. TRAIL/PTX HSA-NPs were fabricated using a high-pressure homogenizer at...

article

In situ facile-forming PEG cross-linked albumin hydrogels loaded with an apoptotic TRAIL protein

Insoo Kim, Ji Su Choi, Seunghyun Lee, Hyeong Jun Byeon, more

Journal of Controlled Release > 2015 > 214 > Complete > 30-39

The key to making a practicable hydrogel for pharmaceutical or medical purposes is to endow it with relevant properties, i.e., facile fabrication, gelation time-controllability, and in situ injectability given a firm basis for safety/biocompatibility. Here, the authors describe an in situ gelling, injectable, albumin-cross-linked polyethylene glycol (PEG) hydrogel that was produced using a thiol–maleimide...

article

Differences in electrophoretic behavior between linear and branched PEG‐conjugated proteins

Eun Ji Park, Myung Sun Kim, Hye Suk Lee, Kang Choon Lee, more

ELECTROPHORESIS > 36 > 6 > 918 - 923

The objective of this study was to characterize the differences in electrophoretic behavior between linear and branched PEG‐conjugated proteins. Human growth hormone and alpha‐lactalbumin modified by linear or branched PEGs with molecular weight of 10 kDa were analyzed by SEC, MALDI‐TOF MS, SDS‐PAGE, and microchip CGE (MCGE). Chromatographic and mass spectrometric differences between the linear and...

article

Hyaluronic acid–tumor necrosis factor-related apoptosis-inducing ligand conjugate for targeted treatment of liver fibrosis

Jeong-A Yang, Won Ho Kong, Dong Kyung Sung, Hyemin Kim, more

Acta Biomaterialia > 2015 > 12 > C > 174-182

Liver fibrosis is a chronic liver disease caused by viral infection and/or metabolic, genetic and cholestatic disorders. The inhibition of hepatic stellate cell (HSC) activation and the selective apoptosis of activated HSCs can be a good strategy to treat liver fibrosis. The activated HSCs are known to be more susceptible to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induced apoptosis...

article

Inhalable self-assembled albumin nanoparticles for treating drug-resistant lung cancer

Seong Ho Choi, Hyeong Jun Byeon, Ji Su Choi, Lequang Thao, more

Journal of Controlled Release > 2015 > 197 > C > 199-207

Direct pulmonary delivery of anti-cancer agents is viewed as an effective way of treating lung cancer. Here, we fabricated inhalable nanoparticles made of human serum albumin (HSA) conjugated with doxorubicin and octyl aldehyde and adsorbed with apoptotic TRAIL protein (TRAIL/Dox HSA-NP). The octyl aldehyde and doxorubicin endowed HSA with significant hydrophobicity that facilitated self-assembly...

article

Evaluation of PEGylated Exendin‐4 Released from Poly (Lactic‐co‐Glycolic Acid) Microspheres for Antidiabetic Therapy

Sung Mook Lim, Ha Na Eom, Hai Hua Jiang, Minji Sohn, more

Journal of Pharmaceutical Sciences > 104 > 1 > 72 - 80

Peptide‐based therapies have the potential to induce antibody formation if the molecules differ from a native human peptide. Several reports have disclosed the occurrence of antibody generation in a patient treated with exenatide. The immune response can be problematic from a clinical stand point, particularly if the antibodies neutralize the efficacy of the biotherapeutic agent or cause a general...

article

Apoptotic activity and antitumor efficacy of PEGylated TNF-related apoptosis-inducing ligand (TRAIL) in a Mia Paca-2 cell-xenografted mouse model

Hyeong Jun Byeon, Seong Ho Choi, Ji Su Choi, Tae Hyung Kim, more

Biomedicine & Pharmacotherapy > 2014 > 68 > 1 > 65-69

The purpose of this study was to demonstrate the apoptotic activity and antitumor effect of PEGylated tumor necrosis factor-related apoptosis-inducing ligand (PEG-TRAIL) in pancreatic carcinoma Mia Paca-2 cells and in Mia Paca-2 cell-xenografted mice. PEG-TRAIL was prepared using mPEG-aldehyde (Mw 5kDa). The apoptosis induced by PEG-TRAIL in Mia Paca-2 cells and in the tumors of Mia Paca-2 cell-xenografted...

article

Decanoic acid-modified glycol chitosan hydrogels containing tightly adsorbed palmityl-acylated exendin-4 as a long-acting sustained-release anti-diabetic system

Changkyu Lee, Ji Su Choi, Insoo Kim, Hyeong Jun Byeon, more

Acta Biomaterialia > 2014 > 10 > 2 > 812-820

Decanoic acid-modified glycol chitosan (DA-GC) hydrogels containing tightly adsorbed palmitic acid-modified exendin-4 (Ex4-C16) were prepared, and their pharmaceutical abilities as a long-acting sustained-release exendin-4 system for the treatment of diabetes were evaluated. Glycol chitosan (GC) was conjugated with N-hydroxysuccinimide-activated decanoic acid (DA) in anhydrous 0.4% dimethylaminopyridine/dimethylsulfoxide...

article

β-cyclodextrin-bearing glycol chitosan for long-acting formulation of an exenatide derivative

Hye Jin Jang, Thavasyappan Thambi, Maharajan Sivasubramanian, Jae Hyun Byun, more

Macromolecular Research > 2014 > 22 > 8 > 816-819

Electronic Supplementary Material Supplementary material is available for this article at 10.1007/s13233-014-2147-1 and is accessible for authorized users.

article

Four-arm PEG cross-linked hyaluronic acid hydrogels containing PEGylated apoptotic TRAIL protein for treating pancreatic cancer

Hyeong Jun Byeon, Seong Ho Choi, Ji Su Choi, Insoo Kim, more

Acta Biomaterialia > 2014 > 10 > 1 > 142-150

Four-arm polyethylene glycol (PEG) cross-linked hyaluronic acid (HA) hydrogels containing PEGylated tumor necrosis factor-related apoptosis-inducing ligand (PEG-TRAIL) were fabricated, and their antitumor effects were evaluated in pancreatic cell (Mia Paca-2)-xenografted mice. HA was conjugated with 4-arm PEG_10k-amine (a cross-linker) at ratios of 100:1 and 100:2 using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide...

article

Doxorubicin-loaded porous PLGA microparticles with surface attached TRAIL for the inhalation treatment of metastatic lung cancer

Insoo Kim, Hyeong Jun Byeon, Tae Hyung Kim, Eun Seong Lee, more

Biomaterials > 2013 > 34 > 27 > 6444-6453

Inhalable highly porous large PLGA microparticles with incorporated doxorubicin and surface-attached with TRAIL (TRAIL/Dox PLGA MP) were fabricated using a w/o/w double emulsification method using ammonium bicarbonate as a gas-foaming agent for the treatment of lung cancer. The TRAIL/Dox PLGA MP produced were highly porous and 11.5 ± 0.4 μm in diameter, and the loading efficiencies of Dox and TRAIL...

article

Rücktitelbild: Mix to Validate: A Facile, Reversible PEGylation for Fast Screening of Potential Therapeutic Proteins In Vivo (Angew. Chem. 27/2013)

Tae Hyung Kim, Magdalena Swierczewska, Yumin Oh, AeRyon Kim, more

Angewandte Chemie > 125 > 27 > 7182 - 7182

Eine verlängerte Halbwertszeit für therapeutische Proteine sollte die Suche nach neuen Proteinwirkstoffen erleichtern. In ihrer Zuschrift auf S. 7018 ff. beschreiben K. C. Lee, S. Lee und Mitarbeiter einen Weg zu diesem Ziel: Sie haben eine spezifische und zuverlässige Methode entwickelt, bei der sie erst Ni‐NTA an Polyethylenglycol konjugieren und dann an Oligohistidin‐markierte therapeutische Proteine...

article

Mix to Validate: A Facile, Reversible PEGylation for Fast Screening of Potential Therapeutic Proteins In Vivo

Tae Hyung Kim, Magdalena Swierczewska, Yumin Oh, AeRyon Kim, more

Angewandte Chemie > 125 > 27 > 7018 - 7022

Umgarntes Protein: Die PEGylierung von Proteinen über komplementäre Wechselwirkungen zwischen einer His‐Markierung und einem Ni²⁺‐Komplex von Nitrilotriessigsäure (NTA; siehe Bild) – ein gängiges Verfahren in der Proteinforschung – verlängert die Halbwertszeit therapeutischer Proteine in der Blutbahn nach systemischer Verabfolgung. In Tiermodellen verbesserte diese ortsspezifische Modifikation die...

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English (106)
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Keywords

PEGYLATION (21)
TRAIL (14)
STABILITY (10)
TYPE 2 DIABETES (10)
EXENDIN-4 (9)
PHARMACOKINETICS (8)
NANOPARTICLES (7)
INHALATION (6)
CAPILLARY ELECTROPHORESIS (5)
DOXORUBICIN (5)
HYALURONIC ACID (5)
PEPTIDE (5)
SALMON CALCITONIN (5)
APOPTOSIS (4)
MICROSPHERES (4)
OCTREOTIDE (4)
PANCREATIC CANCER (4)
ALBUMIN (3)
ALBUMIN NANOPARTICLES (3)
ALBUMIN-BINDING (3)
HPLC (3)
HUMAN PLASMA (3)
MATRIX-ASSISTED LASER DESORPTION/IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY (3)
MICROSPHERE (3)
PEPTIDE ACYLATION (3)
PULMONARY DELIVERY (3)
ACYLATION (2)
ANTITUMOR (2)
BIOLOGICAL ACTIVITY (2)
BIOTINYLATION (2)
BRANCHED PEG (2)
CALCITONIN (2)
CALCITONINS (2)
CONJUGATION (2)
CURCUMIN (2)
CYTOTOXICITY (2)
DEGRADATION (2)
DRUG SCREENING (2)
GLUCAGON-LIKE PEPTIDE-1 (2)
GST-TATDMT (2)
HISTIDINE TAGS (2)
HISTIDIN‐MARKIERUNG (2)
HUMAN SERUM ALBUMIN (2)
HYPOGLYCEMIA (2)
IMMUNOTOXIN (2)
LITHOCHOLIC ACID (2)
LUNG CANCER (2)
MICROCHIP CGE (2)
MONOCLONAL ANTIBODY (2)
NANOCOMPLEX (2)
NANOPARTICLE (2)
OBESITY (2)
ORAL HYPOGLYCEMIC EFFICACY (2)
PALMITYL-ACYLATED EXENDIN-4 (2)
PEGYLIERUNG (2)
PEPTIDE DELIVERY (2)
PEPTIDE STABILITY (2)
PLGA MICROSPHERES (2)
POLY(D,L-LACTIDE-CO-GLYCOLIDE) (2)
POLY(LACTIDE-CO-GLYCOLIDE) (2)
POLYETHYLENE GLYCOL (2)
POROUS MICROPARTICLES (2)
POROUS MICROSPHERES (2)
PROTEIN DELIVERY (2)
PROTEIN DESIGN (2)
PROTEIN MODIFICATIONS (2)
PROTEINDESIGN (2)
PROTEINMODIFIKATIONEN (2)
REVERSED-PHASE HPLC (2)
RHEUMATOID ARTHRITIS (2)
RICIN (2)
RICIN A CHAIN (2)
SELF-ASSEMBLY (2)
SITE-SPECIFIC PEGYLATION (2)
SODIUM DODECYL SULFATE-CAPILLARY GEL ELECTROPHORESIS (2)
TAT (2)
TISSUE DISTRIBUTION (2)
TNF-RELATED APOPTOSIS-INDUCING LIGAND (2)
WIRKSTOFF‐SCREENING (2)
(TNF)‐RELATED APOPTOSIS INDUCING LIGAND (TRAIL) (1)
4-ARM PEG (1)
ABSORPTION (1)
ACTIVE TUMOR TARGETING (1)
ADVANCED PULMONARY DELIVERY OF PEPTIDES OR PROTEINS USING POLYMERIC PARTICLES (1)
ALBUMIN BINDING (1)
ALBUMIN-COATING (1)
ANTI-CANCER AGENT (1)
ANTIDIABETIC EFFECTS (1)
ANTIOXIDANT ACTIVITY (1)
ANTITUMOR EFFICACY (1)
APO2L LIGAND/TUMOR NECROSIS FACTOR (1)
APOPTOTIC ACTIVITY (1)
ARG-GLY-ASP (1)
AUTOIMMUNE DISEASES (1)
BIOACTIVITY (1)
BIOAVAILABILITY (1)
BIOCONJUGATION (1)
BIOTIN (1)
BUCILLAMINE (1)
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Elsevier (66)
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Journal of Controlled Release (15)
International Journal of Pharmaceutics (13)
Biomaterials (8)
Bioconjugate Chemistry (6)
Pharmaceutical Research (5)
Regulatory Peptides (5)
AAPS PharmSciTech (4)
Journal of Chromatography B: Biomedical Sciences and Applications (4)
Acta Biomaterialia (3)
Angewandte Chemie (3)
Angewandte Chemie International Edition (3)
Archives of Pharmacal Research (3)
Journal of Chromatography B (3)
Analytical Biochemistry (2)
Biotechnology Letters (2)
ELECTROPHORESIS (2)
Journal of Chromatography A (2)
Journal of Natural Products (2)
Journal of Pharmaceutical Sciences (2)
Analytical Chemistry (1)
Archives of Toxicology (1)
Biochemical Pharmacology (1)
Biomedicine & Pharmacotherapy (1)
Chromatographia (1)
European Journal of Pharmaceutics and Biopharmaceutics (1)
Hepatology (1)
International Journal of Biochemistry and Cell Biology (1)
Journal of Bioscience and Bioengineering (1)
Journal of Drug Delivery Science and Technology (1)
Journal of Immunological Methods (1)
Journal of Medicinal Chemistry (1)
Journal of Pharmaceutical and Biomedical Analysis (1)
Journal of Pharmacy and Pharmacology (1)
Macromolecular Research (1)
Protein Expression and Purification (1)
Talanta (1)
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INFONA - science communication portal

Search results for: Kang Choon Lee

PEGylated TRAIL ameliorates experimental inflammatory arthritis by regulation of Th17 cells and regulatory T cells

The synthesis of tamoxifen-loaded albumin nanoparticles by homogenizers: Optimization and in vitro characterization

Reducing agent-free synthesis of curcumin-loaded albumin nanoparticles by self-assembly at room temperature

Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells

Doxorubicin-Bound Albumin Nanoparticles Containing a TRAIL Protein for Targeted Treatment of Colon Cancer

Delivery of tumor-homing TRAIL sensitizer with long-acting TRAIL as a therapy for TRAIL-resistant tumors

Mono-lithocholated exendin-4-loaded glycol chitosan nanoparticles with prolonged antidiabetic effects

Facile one-pot formulation of TRAIL-embedded paclitaxel-bound albumin nanoparticles for the treatment of pancreatic cancer

In situ facile-forming PEG cross-linked albumin hydrogels loaded with an apoptotic TRAIL protein

Differences in electrophoretic behavior between linear and branched PEG‐conjugated proteins

Hyaluronic acid–tumor necrosis factor-related apoptosis-inducing ligand conjugate for targeted treatment of liver fibrosis

Inhalable self-assembled albumin nanoparticles for treating drug-resistant lung cancer

Evaluation of PEGylated Exendin‐4 Released from Poly (Lactic‐co‐Glycolic Acid) Microspheres for Antidiabetic Therapy

Apoptotic activity and antitumor efficacy of PEGylated TNF-related apoptosis-inducing ligand (TRAIL) in a Mia Paca-2 cell-xenografted mouse model

Decanoic acid-modified glycol chitosan hydrogels containing tightly adsorbed palmityl-acylated exendin-4 as a long-acting sustained-release anti-diabetic system

β-cyclodextrin-bearing glycol chitosan for long-acting formulation of an exenatide derivative

Four-arm PEG cross-linked hyaluronic acid hydrogels containing PEGylated apoptotic TRAIL protein for treating pancreatic cancer

Doxorubicin-loaded porous PLGA microparticles with surface attached TRAIL for the inhalation treatment of metastatic lung cancer

Rücktitelbild: Mix to Validate: A Facile, Reversible PEGylation for Fast Screening of Potential Therapeutic Proteins In Vivo (Angew. Chem. 27/2013)

Mix to Validate: A Facile, Reversible PEGylation for Fast Screening of Potential Therapeutic Proteins In Vivo

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