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Normal human somatic cells can only divide for a limited number of times. This phenomenon has been regarded as a reflection of individual aging at the cellular level. Experimental evidences suggest that a cell's division potential is limited by the physical length of telomeres that gradually shorten through successive cell divisions. At present, it is not clear whether such a limit is imposed by the...
Cultures of normal human cell can only undergo a finite number of population doublings. The proliferative life span of a culture is affected by population size, i.e., the number of cells a culture maintains. A 1000-fold transient reduction in population size can reduce the life span by as many as eight population doublings. The limited proliferative potential of human cells has been speculated to...
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