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Long-term L-3,4-dihydroxyphenylalanine (L-DOPA) treatment in Parkinson's disease (PD) is associated with motor complications such as dyskinesia. There are clear functional interactions between dopaminergic and serotonergic type 2A receptors (5-HT 2A )-mediated neurotransmission. Moreover, 5-HT 2A receptor antagonists can reduce L-DOPA-induced dyskinesia (LID). We hypothesized that...
Well‐formed visual hallucinations (VH) are common in patients with Parkinson's disease (PD). The pathophysiology of VH in PD is unknown but may involve structures mediating visual processing such as the inferior temporal cortex. Serotonergic type 2A (5‐HT2A) receptors have been linked to many psychiatric disorders, including psychosis. We hypothesized that enhanced 5‐HT2A receptor levels may be involved...
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