Search results for: Sebastien Ourselin

Items from 1 to 20 out of 412 results

article

Cutaneous manifestations of SARS‐CoV‐2 infection during the Delta and Omicron waves in 348 691 UK users of the UK ZOE COVID Study app*

Alessia Visconti, Benjamin Murray, Niccolò Rossi, Jonathan Wolf, more

British Journal of Dermatology > 187 > 6 > 900 - 908

Background Symptoms of SARS‐CoV‐2 infection have differed during the different waves of the pandemic but little is known about how cutaneous manifestations have changed. Objectives To investigate the diagnostic value, frequency and duration of cutaneous manifestations of SARS‐CoV‐2 infection and to explore their variations between the Delta and Omicron waves of the pandemic. Methods In this retrospective...

article

Idea, Development, Exploration, Assessment, Long‐term follow‐up study (IDEAL) Stage 1/2a evaluation of urological procedures with the Versius robot

Fairleigh Reeves, Ben Challacombe, Alexander Ribbits, Sebastien Ourselin, more

BJU International > 130 > 4 > 441 - 443

article

Optical properties of human brain and tumour tissue: An ex vivo study spanning the visible range to beyond the second near‐infrared window

Jonathan Shapey, Yijing Xie, Elham Nabavi, Michael Ebner, more

Journal of Biophotonics > 15 > 4 > n/a - n/a

Neuro‐oncology surgery would benefit from detailed intraoperative tissue characterization provided by noncontact, contrast‐agent‐free, noninvasive optical imaging methods. In‐depth knowledge of target tissue optical properties across a wide‐wavelength spectrum could inform the design of optical imaging and computational methods to enable robust tissue analysis during surgery. We adapted a dual‐beam...

article

Data‐driven staging of genetic frontotemporal dementia using multi‐modal MRI

Jillian McCarthy, Barbara Borroni, Raquel Sanchez‐Valle, Fermin Moreno, more

Human Brain Mapping > 43 > 6 > 1821 - 1835

Frontotemporal dementia in genetic forms is highly heterogeneous and begins many years to prior symptom onset, complicating disease understanding and treatment development. Unifying methods to stage the disease during both the presymptomatic and symptomatic phases are needed for the development of clinical trials outcomes. Here we used the contrastive trajectory inference (cTI), an unsupervised machine...

article

Fetoscopic insufflation of heated‐humidified carbon dioxide during simulated spina bifida repair is safe under controlled anesthesia in the fetal lamb

Luc Joyeux, David Basurto, Tom Bleeser, Lennart Van der Veeken, more

Prenatal Diagnosis > 42 > 2 > 180 - 191

Objective To assess the safety of Partial‐Amniotic‐Insufflation‐of‐heated‐humidified‐CO₂ (hPACI) during fetoscopic spina bifida repair (fSB‐repair). Method A simulated fSB‐repair through an exteriorized uterus under hPACI was performed in 100‐day fetal lambs (term = 145 days) under a laboratory anesthesia protocol (n = 5; group 1) which is known to induce maternal‐fetal acidosis and hypercapnia...

article

Stratifying the Presymptomatic Phase of Genetic Frontotemporal Dementia by Serum NfL and pNfH: A Longitudinal Multicentre Study

Carlo Wilke, Selina Reich, John C. Swieten, Barbara Borroni, more

Annals of Neurology > 91 > 1 > 33 - 47

Objective Although the presymptomatic stages of frontotemporal dementia (FTD) provide a unique chance to delay or even prevent neurodegeneration by early intervention, they remain poorly defined. Leveraging a large multicenter cohort of genetic FTD mutation carriers, we provide a biomarker‐based stratification and biomarker cascade of the likely most treatment‐relevant stage within the presymptomatic...

article

Incidence and patterns of abnormal corpus callosum in fetuses with isolated spina bifida aperta

Yada Kunpalin, Jan Deprest, Ioannis Papastefanou, Emma Bredaki, more

Prenatal Diagnosis > 41 > 8 > 957 - 964

Objective To determine the incidence and characterise corpus callosum (CC) abnormalities in fetuses with spina bifida aperta (SBA) between 18 and 26 weeks of gestation. Methods This was a retrospective study on fetuses with isolated SBA and who were assessed for fetal surgery. Digitally stored ultrasound images of the brain were reviewed for the presence/absence of the CC, and the length and diameter...

article

Preclinical stem cell therapy in fetuses with myelomeningocele: A systematic review and meta‐analysis

Yada Kunpalin, Sindhu Subramaniam, Silvia Perin, Mattia F. M. Gerli, more

Prenatal Diagnosis > 41 > 3 > 283 - 300

Objective We performed a systematic review to summarize the efficacy and safety of in utero stem cells application in preclinical models with myelomeningocele (MMC). Methods The study was registered with PROSPERO (CRD42019160399). We searched MEDLINE, Embase, Web of Science, Scopus and CENTRAL for publications articles on stem cell therapy in animal fetuses with MMC until May 2020. Publication...

article

Dimensionless squared jerk: An objective differential to assess experienced and novice probe movement in obstetric ultrasound

Brian P Dromey, Shahanaz Ahmed, Francisco Vasconcelos, Evangelos Mazomenos, more

Prenatal Diagnosis > 41 > 2 > 271 - 277

Objective Widely accepted, validated and objective measures of ultrasound competency have not been established for clinical practice. Outcomes of training curricula are often based on arbitrary thresholds, such as the number of clinical cases completed. We aimed to define metrics against which competency could be measured. Method We undertook a prospective, observational study of obstetric sonographers...

article

Sodium in the Relapsing–Remitting Multiple Sclerosis Spinal Cord: Increased Concentrations and Associations With Microstructural Tissue Anisotropy

Bhavana S. Solanky, Ferran Prados, Carmen Tur, Marios C. Yiannakas, more

Journal of Magnetic Resonance Imaging > 52 > 5 > 1429 - 1438

Background Associations between brain total sodium concentration, disability, and disease progression have recently been reported in multiple sclerosis. However, such measures in spinal cord have not been reported. Purpose To measure total sodium concentration (TSC) alterations in the cervical spinal cord of people with relapsing–remitting multiple sclerosis (RRMS) and a control cohort using sodium...

article

Front Cover: Photoacoustic imaging of the human placental vasculature (J. Biophotonics 4/2020)

Efthymios Maneas, Rosalind Aughwane, Nam Huynh, Wenfeng Xia, more

Journal of Biophotonics > 13 > 4 > 1214 - 1229

Successful therapy of twin‐to‐twin transfusion syndrome requires accurate imaging to guide laser photocoagulation of the anastomosing placental vessels. Photoacoustic (PA) imaging is an alternative imaging method that provides contrast for hemoglobin, and in this study, it was used to visualize chorionic superficial and subsurface vasculature in human placentas. The strong potential of PA imaging...

article

Photoacoustic imaging of the human placental vasculature

Efthymios Maneas, Rosalind Aughwane, Nam Huynh, Wenfeng Xia, more

Journal of Biophotonics > 13 > 4 > n/a - n/a

Minimally invasive fetal interventions require accurate imaging from inside the uterine cavity. Twin‐to‐twin transfusion syndrome (TTTS), a condition considered in this study, occurs from abnormal vascular anastomoses in the placenta that allow blood to flow unevenly between the fetuses. Currently, TTTS is treated fetoscopically by identifying the anastomosing vessels, and then performing laser photocoagulation...

article

Improved fetal blood oxygenation and placental estimated measurements of diffusion‐weighted MRI using data‐driven Bayesian modeling

Dimitra Flouri, David Owen, Rosalind Aughwane, Nada Mufti, more

Magnetic Resonance in Medicine > 83 > 6 > 2160 - 2172

Purpose Motion correction in placental DW‐MRI is challenging due to maternal breathing motion, maternal movements, and rapid intensity changes. Parameter estimates are usually obtained using least‐squares methods for voxel‐wise fitting; however, they typically give noisy estimates due to low signal‐to‐noise ratio. We introduce a model‐driven registration (MDR) technique which incorporates a placenta‐specific...

article

Hippocampal profiling: Localized magnetic resonance imaging volumetry and T2 relaxometry for hippocampal sclerosis

Sjoerd B. Vos, Gavin P. Winston, Olivia Goodkin, Hugh G. Pemberton, more

Epilepsia > 61 > 2 > 297 - 309

Objective Hippocampal sclerosis (HS) is the most common cause of drug‐resistant temporal lobe epilepsy, and its accurate detection is important to guide epilepsy surgery. Radiological features of HS include hippocampal volume loss and increased T2 signal, which can both be quantified to help improve detection. In this work, we extend these quantitative methods to generate cross‐sectional area and...

article

A 30‐Year Clinical and Magnetic Resonance Imaging Observational Study of Multiple Sclerosis and Clinically Isolated Syndromes

Karen K. Chung, Daniel Altmann, Frederik Barkhof, Katherine Miszkiel, more

Annals of Neurology > 87 > 1 > 63 - 74

Objective Clinical outcomes in multiple sclerosis (MS) are highly variable. We aim to determine the long‐term clinical outcomes in MS, and to identify early prognostic features of these outcomes. Methods One hundred thirty‐two people presenting with a clinically isolated syndrome were prospectively recruited between 1984 and 1987, and followed up clinically and radiologically 1, 5, 10, 14, 20,...

article

Learning to see the invisible: A data‐driven approach to finding the underlying patterns of abnormality in visually normal brain magnetic resonance images in patients with temporal lobe epilepsy

Oscar F. Bennett, Baris Kanber, Chandrashekar Hoskote, M. Jorge Cardoso, more

Epilepsia > 60 > 12 > 2499 - 2507

Objective To find the covert patterns of abnormality in patients with unilateral temporal lobe epilepsy (TLE) and visually normal brain magnetic resonance images (MRI‐negative), comparing them to those with visible abnormalities (MRI‐positive). Methods We used multimodal brain MRI from patients with unilateral TLE and employed contemporary machine learning methods to predict the known laterality...

article

Longitudinal spinal cord atrophy in multiple sclerosis using the generalized boundary shift integral

Marcello Moccia, Ferran Prados, Massimo Filippi, Maria A. Rocca, more

Annals of Neurology > 86 > 5 > 704 - 713

Objective Spinal cord atrophy is a clinically relevant feature of multiple sclerosis (MS), but longitudinal assessments on magnetic resonance imaging using segmentation‐based methods suffer from measurement variability, especially in multicenter studies. We compared the generalized boundary shift integral (GBSI), a registration‐based method, with a standard segmentation‐based method. Methods Baseline...

article

Stereoelectroencephalography electrode placement: Detection of blood vessel conflicts

Kuo Li, Vejay N. Vakharia, Rachel Sparks, Roman Rodionov, more

Epilepsia > 60 > 9 > 1942 - 1948

Objective Various forms of vascular imaging are performed to identify vessels that should be avoided during stereoelectroencephalography (SEEG) planning. Digital subtraction angiography (DSA) is the gold standard for intracranial vascular imaging. DSA is an invasive investigation, and a balance is necessary to identify all clinically relevant vessels and not to visualize irrelevant vessels that may...

article

Multicenter validation of automated trajectories for selective laser amygdalohippocampectomy

Vejay N. Vakharia, Rachel E. Sparks, Kuo Li, Aidan G. O'Keeffe, more

Epilepsia > 60 > 9 > 1949 - 1959

Objective Laser interstitial thermal therapy (LITT) is a novel minimally invasive alternative to open mesial temporal resection in drug‐resistant mesial temporal lobe epilepsy (MTLE). The safety and efficacy of the procedure are dependent on the preplanned trajectory and the extent of the planned ablation achieved. Ablation of the mesial hippocampal head has been suggested to be an independent predictor...

article

Intraoperative multispectral and hyperspectral label‐free imaging: A systematic review of in vivo clinical studies

Jonathan Shapey, Yijing Xie, Eli Nabavi, Robert Bradford, more

Journal of Biophotonics > 12 > 9 > n/a - n/a

Multispectral and hyperspectral imaging (HSI) are emerging optical imaging techniques with the potential to transform the way surgery is performed but it is not clear whether current systems are capable of delivering real‐time tissue characterization and surgical guidance. We conducted a systematic review of surgical in vivo label‐free multispectral and HSI systems that have been assessed intraoperatively...

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INFONA - science communication portal

Search results for: Sebastien Ourselin

Cutaneous manifestations of SARS‐CoV‐2 infection during the Delta and Omicron waves in 348 691 UK users of the UK ZOE COVID Study app*

Idea, Development, Exploration, Assessment, Long‐term follow‐up study (IDEAL) Stage 1/2a evaluation of urological procedures with the Versius robot

Optical properties of human brain and tumour tissue: An ex vivo study spanning the visible range to beyond the second near‐infrared window

Data‐driven staging of genetic frontotemporal dementia using multi‐modal MRI

Fetoscopic insufflation of heated‐humidified carbon dioxide during simulated spina bifida repair is safe under controlled anesthesia in the fetal lamb

Stratifying the Presymptomatic Phase of Genetic Frontotemporal Dementia by Serum NfL and pNfH: A Longitudinal Multicentre Study

Incidence and patterns of abnormal corpus callosum in fetuses with isolated spina bifida aperta

Preclinical stem cell therapy in fetuses with myelomeningocele: A systematic review and meta‐analysis

Dimensionless squared jerk: An objective differential to assess experienced and novice probe movement in obstetric ultrasound

Sodium in the Relapsing–Remitting Multiple Sclerosis Spinal Cord: Increased Concentrations and Associations With Microstructural Tissue Anisotropy

Front Cover: Photoacoustic imaging of the human placental vasculature (J. Biophotonics 4/2020)

Photoacoustic imaging of the human placental vasculature

Improved fetal blood oxygenation and placental estimated measurements of diffusion‐weighted MRI using data‐driven Bayesian modeling

Hippocampal profiling: Localized magnetic resonance imaging volumetry and T2 relaxometry for hippocampal sclerosis

A 30‐Year Clinical and Magnetic Resonance Imaging Observational Study of Multiple Sclerosis and Clinically Isolated Syndromes

Learning to see the invisible: A data‐driven approach to finding the underlying patterns of abnormality in visually normal brain magnetic resonance images in patients with temporal lobe epilepsy

Longitudinal spinal cord atrophy in multiple sclerosis using the generalized boundary shift integral

Stereoelectroencephalography electrode placement: Detection of blood vessel conflicts

Multicenter validation of automated trajectories for selective laser amygdalohippocampectomy

Intraoperative multispectral and hyperspectral label‐free imaging: A systematic review of in vivo clinical studies

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