Search results for: Maria Walczak

Items from 1 to 20 out of 34 results

article

Vascular protein disulfide isomerase A1 mediates endothelial dysfunction induced by angiotensin II in mice

Agnieszka Kij, Anna Bar, Izabela Czyzynska‐Cichon, Kamil Przyborowski, more

Aim Protein disulfide isomerases (PDIs) are involved in platelet aggregation and intravascular thrombosis, but their role in regulating endothelial function is unclear. Here, we characterized the involvement of vascular PDIA1 in angiotensin II (Ang II)‐induced endothelial dysfunction in mice. Methods Endothelial dysfunction was induced in C57BL/6JCmd male mice via Ang II subcutaneous infusion,...

article

Promising anticonvulsant and/or analgesic compounds among 5‐chloro‐2‐ or 5‐chloro‐4‐methyl derivatives of xanthone coupled to aminoalkanol moieties—Design, synthesis and pharmacological evaluation

Gabriela Mazur, Katarzyna Pańczyk‐Straszak, Anna Rapacz, Jan Kiszela, more

Chemical Biology & Drug Design > 101 > 2 > 278 - 325

A series of 10 aminoalkanol derivatives of 5‐chloro‐2‐ or 5‐chloro‐4‐methylxanthone was synthetized and evaluated for anticonvulsant properties (MES test, mice, intraperitoneal) and compared with neurotoxicity rotarod test (NT, mice, i.p.). The best results both in terms of anticonvulsant activity and protective index value were obtained for 3: 5‐chloro‐2‐([4‐hydroxypiperidin‐1‐yl]methyl)‐9H‐xanthen‐9‐one...

article

Xanthotoxin enhances the anticonvulsant potency of levetiracetam and valproate in the 6‐Hz corneal stimulation model in mice

Mirosław Zagaja, Jarosław Bryda, Aleksandra Szewczyk, Joanna Szala‐Rycaj, more

Fundamental & Clinical Pharmacology > 36 > 1 > 133 - 142

Xanthotoxin (8‐methoxypsoralen; XANT) is a furanocoumarin that has many biological properties, including antiepileptic activity. This study evaluated the effect of XANT on the ability of classical and novel antiepileptic drugs to prevent seizures evoked by the 6‐Hz corneal stimulation‐induced seizure model, which is thought to be an experimental model of psychomotor (limbic) seizures in humans. XANT...

article

KA‐104, a new multitargeted anticonvulsant with potent antinociceptive activity in preclinical models

Krzysztof Kamiński, Szczepan Mogilski, Michał Abram, Anna Rapacz, more

Epilepsia > 61 > 10 > 2119 - 2128

Objective The main objective of the present work was to assess the utility of KA‐104 as potential therapy for drug‐resistant seizures and neuropathic pain, and to characterize its druglike properties in a series of absorption, distribution, metabolism, excretion and toxicity (ADME‐Tox) studies. We also aimed to establish its mechanism of action in electrophysiological studies. Methods The activity...

article

Dwa sposoby interpretacji problemu intersubiektywności w późnej filozofii Husserla i propozycje jego rozwiązania na przykładzie filozofii M. Henry’ego i M. Richira

Maria Walczak

Analiza i Egzystencja. Czasopismo Filozoficzne > 2020 > 51 > 5-22

This article is an analysis of two conceptions of both awareness of other persons and relations with them put forward by Michel Henry and Marc Richir – philosophers who are associated with “new phenomenology in France”. My aim is to show how they reinterpret Husserl’s view of intersubjectvity and attempt to solve the issues related to traditional phenomenological solution. Thanks to rejecting Husserl’s...

article

Lipophilicity profiling of anthracycline antibiotics by microemulsion electrokinetic chromatography–effects on cardiotoxicity and endotheliotoxicity

Karolina Matyjaszczyk‐Gwarda, Tomasz Wójcik, Małgorzata Łukawska, Stefan Chlopicki, more

ELECTROPHORESIS > 40 > 23-24 > 3108 - 3116

Accurate profiling of the lipophilicity of amphoteric compounds might be complex and laborious. In the present work the lipophilicity of 12 anthracycline antibiotics–four parent drugs: doxorubicin, daunorubicin, epidoxorubicin, and epidaunorubicin and eight novel formamidyne derivatives with attached morpholine, hexamethylenoimine or piperidine rings–was determined based on novel approach using MEEKC...

article

Benzophenone-2 Concentration and Its Effect on Oxidative Stress and Apoptosis Markers in Rat Brain

Żaneta Broniowska, Beata Bystrowska, Beata Starek-Świechowicz, Bartosz Pomierny, more

Neurotoxicity Research > 2019 > 36 > 1 > 39-48

Benzophenones, frequently used as UV chemical filters, are absorbed through the skin and can exert systemic adverse effects. So far, most of the data are related to their action on sex hormone receptors whereas potential neurotoxic effect is expected mainly on the basis of in vitro studies. The aim of the present study was to determine concentrations of BP-2, oxidative stress and apoptosis markers...

article

Wpływ oddziaływania wiązki laserowej na skłonność tkanin poliestrowych do pilingu

Ewa Korzeniewska, Maria Walczak, Joanna Sekulska-Nalewajko, Jarosław Gocławski

Przegląd Elektrotechniczny > 2019 > R. 95, nr 1 > 73--76

W artykule opisano wpływ modyfikacji powierzchni tkanin poliestrowych z wykorzystaniem wiązki laserowej. Ocenę tendencji do pilingu wykonano w oparciu o analizę obrazów 2D oraz 3D pozyskanych z wykorzystaniem optycznego tomografu koherentnego. Zaobserwowano, pozytywny wpływ obróbki laserowej na zmniejszającą się liczbę poluzowanych pojedynczych nitek wystających ponad powierzchnię tkaniny, a w efekcie...

article

Alterations in arginine and energy metabolism, structural and signalling lipids in metastatic breast cancer in mice detected in plasma by targeted metabolomics and lipidomics

Kamil Kus, Agnieszka Kij, Agnieszka Zakrzewska, Agnieszka Jasztal, more

Breast Cancer Research > 2018 > 20 > 1 > 1-13

Background The early detection of metastasis based on biomarkers in plasma may improve cancer prognosis and guide treatment. The aim of this work was to characterize alterations in metabolites of the arginine pathway, energy metabolism, and structural and signalling lipids in plasma in the early and late stages of murine breast cancer metastasis. Methods Mice were orthotopically inoculated with...

article

Development, validation and application of a micro–liquid chromatography–tandem mass spectrometry based method for simultaneous quantification of selected protein biomarkers of endothelial dysfunction in murine plasma

Joanna Suraj, Anna Kurpińska, Mariola Olkowicz, Ewa Niedzielska–Andres, more

Journal of Pharmaceutical and Biomedical Analysis > 2018 > 149 > C > 465-474

The objective of this study was to develop and validate the method based on micro–liquid chromatography–tandem mass spectrometry (microLC/MS–MRM) for simultaneous determination of adiponectin (ADN), von Willebrand factor (vWF), soluble form of vascular cell adhesion molecule 1 (sVCAM–1), soluble form of intercellular adhesion molecule 1 (sICAM–1) and syndecan–1 (SDC–1) in mouse plasma. The calibration...

article

Kategoria pasywności w fenomenologii materialnej Michela Henry`ego

Maria Walczak

Kwartalnik Filozoficzny > 2018 > 46 > 4 > 5-21

The aim of this article is to analyze the notion of passivity in Michel Henry's material phenomenology. I focus on three main issues: noetic-noematic structure, internal time consciousness, and phenomenological method. What I consider my main reference point is the classical Husserlian version of phenomenology, which is what is discussed by Michel Henry. In particular, I pay attention to those of...

article

Study on the effect of EMD386088, a 5-HT₆ receptor partial agonist, in enhancing the anti-immobility action of some antidepressants in rats

Magdalena Jastrzębska-Więsek, Agata Siwek, Anna Partyka, Marcin Kołaczkowski, more

Naunyn-Schmiedeberg's Archives of Pharmacology > 2018 > 391 > 1 > 37-49

The effect of some antidepressants co-administered with EMD386088 in the modified forced swim test in rats was investigated. Additionally, the pharmacokinetics, metabolic stability, and the effect of EMD386088 on P450 cytochromes were determined. Intraperitoneal (i.p.) coadministration of EMD386088 (2.5 mg/kg) and imipramine (15 mg/kg), reboxetine (5 mg/kg), moclobemide (10 mg/kg), or bupropion (10 mg/kg)...

article

HBK-15 protects mice from stress-induced behavioral disturbances and changes in corticosterone, BDNF, and NGF levels

Karolina Pytka, Monika Głuch-Lutwin, Magdalena Kotańska, Elżbieta Żmudzka, more

Behavioural Brain Research > 2017 > 333 > C > 54-66

Unlike majority of current antidepressants, HBK-15–a 5-HT_1A and 5-HT₇ receptor antagonist – showed memory-enhancing properties. In this study, we aimed to further characterize pharmacological profile of HBK-15 and investigate its antidepressant- and anxiolytic-like activity in the mouse model of unpredictable chronic mild stress. We used sucrose consumption test, forced swim test and elevated plus...

article

Effects of structural modification of the daunosamine moiety of anthracycline antibiotics on pKa values determined by capillary zone electrophoresis

Karolina Matyjaszczyk, Marta Kolonko, Anna Gonciarz-Dytman, Irena Oszczapowicz, more

Journal of Chromatography B > 2017 > 1060 > C > 44-52

The thermodynamic acid dissociation constants (pK_a1 and pK_a2) of 16 anthracycline antibiotics, including doxorubicin (DOX) and daunorubicin (DAU), their epimers, epidoxorubicin (EDOX) and epidaunorubicin (EDAU), as well as novel anthracycline derivatives containing piperidine (FPIP), morpholine (FMOR) and hexamethylenoimine (FHEX) rings in the formamidine group of the daunosamine moiety were determined...

chapter

Elements of elastic electronics created on textile substrate

Ewa Korzeniewska, Maria Walczak, Jacek Rymaszewski

2017 MIXDES - 24th International Conference "Mixed Design of Integrated Circuits and Systems > 447 - 450

2017 MIXDES - 24th International Conference "Mixed Design of Integrated Circuits and Systems"

The most well-known method for producing conductive elements for flexible electronics is to print the paths of electronic circuits directly onto polymer materials. The authors of the paper propose an alternative solution for creation of conductive elements such as using PVD vacuum deposition technology and laser shaping. The resistors and conductors obtained in this way have good electrical and mechanical...

chapter

Durability and reliability enhancement of selected electronic components achieved by laser technologies

Ryszard Pawlak, Mariusz Tomczyk, Maria Walczak

2017 MIXDES - 24th International Conference "Mixed Design of Integrated Circuits and Systems > 459 - 462

2017 MIXDES - 24th International Conference "Mixed Design of Integrated Circuits and Systems"

The article presents selected laser technologies designed to increase the reliability of some of electrical and electronic components. They include technology of connecting, surface modification or precise shaping. The technique of laser welding as more reliable joining than the traditional technique of thermo-compression and ultra-compression has been described. Our method of welding of thin wires...

article

Single Administration of HBK-15—a Triple 5-HT_1A, 5-HT₇, and 5-HT₃ Receptor Antagonist—Reverses Depressive-Like Behaviors in Mouse Model of Depression Induced by Corticosterone

Karolina Pytka, Monika Głuch-Lutwin, Magdalena Kotańska, Anna Waszkielewicz, more

Molecular Neurobiology > 2018 > 55 > 5 > 3931-3945

Studies suggest that the blockade of 5-HT_1A, 5-HT₇, and 5-HT₃ receptor may increase the speed of antidepressant response. 1-[(2,6-Dimethylphenoxy)ethoxyethyl]-4-(2-methoxyphenyl)piperazine hydrochloride (HBK-14) and 1-[(2-chloro-6-methylphenoxy)ethoxyethyl]-4-(2-methoxyphenyl)piperazine hydrochloride (HBK-15), dual 5-HT_1A and 5-HT₇ antagonists, showed significant antidepressant- and anxiolytic-like...

article

Simultaneous quantification of PGI2 and TXA2 metabolites in plasma and urine in NO-deficient mice by a novel UHPLC/MS/MS method

Agnieszka Kij, Lukasz Mateuszuk, Barbara Sitek, Kamil Przyborowski, more

Journal of Pharmaceutical and Biomedical Analysis > 2016 > 129 > C > 148-154

The balance between vascular prostacyclin (PGI₂) generated mainly via cyclooxygenase-2 (COX-2) and its physiological antagonist platelet-derived thromboxane A₂ (TXA₂) formed by cyclooxygenase-1 (COX-1) determines cardiovascular homeostasis. In the present work, a novel bioanalytical method for simultaneous quantification of stable plasma and urinary metabolites of PGI₂ (6-keto-PGF_1α, 2,3-dinor-6-keto-PGF...

article

Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension

Andrzej Fedorowicz, Łukasz Mateuszuk, Grzegorz Kopec, Tomasz Skórka, more

Respiratory Research > 2016 > 17 > 1 > 1-13

Background Pulmonary arterial hypertension (PAH) is associated with inflammatory response but it is unknown whether it is associated with alterations in NNMT activity and MNA plasma concentration. Here we examined changes in NNMT-MNA pathway in PAH in rats and humans. Methods PAH in rats was induced by a single subcutaneous injection of MCT (60 mg/kg). Changes in NNMT activity in the lungs and liver...

article

The antidepressant-like activity of 6-methoxy-2-[4-(2-methoxyphenyl)piperazin-1-yl]-9H-xanthen-9-one involves serotonergic 5-HT1A and 5-HT2A/C receptors activation

Karolina Pytka, Maria Walczak, Agnieszka Kij, Anna Rapacz, more

European Journal of Pharmacology > 2015 > 764 > Complete > 537-546

Xanthone derivatives have been shown to posses many biological properties. Some of them act within the central nervous system and show neuroprotective or antidepressant-like properties. Taking this into account we investigated antidepressant-like activity in mice and the possible mechanism of action of 6-methoxy-2-[4-(2-methoxyphenyl)piperazin-1-yl]-9H-xanthen-9-one (HBK-11) – a new xanthone derivative...

Publication date

Last year (1)
Last 3 years (3)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

Data set

Elsevier (12)
Wiley (10)
Springer (5)
CEJSH (3)
ieee (2)
BazTech (1)
PSJD (1)

Journal

Biomedical Chromatography (2)
Bioorganic & Medicinal Chemistry (2)
Chirality (2)
ELECTROPHORESIS (2)
Journal of Pharmaceutical and Biomedical Analysis (2)
Acta Physiologica (1)
Analiza i Egzystencja. Czasopismo Filozoficzne (1)
Behavioural Brain Research (1)
Biochemical Pharmacology (1)
Breast Cancer Research (1)
Chemical Biology & Drug Design (1)
Epilepsia (1)
European Journal of Medicinal Chemistry (1)
European Journal of Pharmacology (1)
Fundamental & Clinical Pharmacology (1)
International Immunopharmacology (1)
Internetowy Magazyn Filozoficzny Hybris (1)
Journal of Chromatography A (1)
Journal of Chromatography B (1)
Kwartalnik Filozoficzny (1)
Molecular Neurobiology (1)
Naunyn-Schmiedeberg's Archives of Pharmacology (1)
Neurotoxicity Research (1)
Ogrody Nauk i Sztuk (1)
Przegląd Elektrotechniczny (1)
Respiratory Research (1)
Talanta (1)
more

INFONA - science communication portal

Search results for: Maria Walczak

Vascular protein disulfide isomerase A1 mediates endothelial dysfunction induced by angiotensin II in mice

Promising anticonvulsant and/or analgesic compounds among 5‐chloro‐2‐ or 5‐chloro‐4‐methyl derivatives of xanthone coupled to aminoalkanol moieties—Design, synthesis and pharmacological evaluation

Xanthotoxin enhances the anticonvulsant potency of levetiracetam and valproate in the 6‐Hz corneal stimulation model in mice

KA‐104, a new multitargeted anticonvulsant with potent antinociceptive activity in preclinical models

Dwa sposoby interpretacji problemu intersubiektywności w późnej filozofii Husserla i propozycje jego rozwiązania na przykładzie filozofii M. Henry’ego i M. Richira

Lipophilicity profiling of anthracycline antibiotics by microemulsion electrokinetic chromatography–effects on cardiotoxicity and endotheliotoxicity

Benzophenone-2 Concentration and Its Effect on Oxidative Stress and Apoptosis Markers in Rat Brain

Wpływ oddziaływania wiązki laserowej na skłonność tkanin poliestrowych do pilingu

Alterations in arginine and energy metabolism, structural and signalling lipids in metastatic breast cancer in mice detected in plasma by targeted metabolomics and lipidomics

Development, validation and application of a micro–liquid chromatography–tandem mass spectrometry based method for simultaneous quantification of selected protein biomarkers of endothelial dysfunction in murine plasma

Kategoria pasywności w fenomenologii materialnej Michela Henry`ego

Study on the effect of EMD386088, a 5-HT₆ receptor partial agonist, in enhancing the anti-immobility action of some antidepressants in rats

HBK-15 protects mice from stress-induced behavioral disturbances and changes in corticosterone, BDNF, and NGF levels

Effects of structural modification of the daunosamine moiety of anthracycline antibiotics on pKa values determined by capillary zone electrophoresis

Elements of elastic electronics created on textile substrate

Durability and reliability enhancement of selected electronic components achieved by laser technologies

Single Administration of HBK-15—a Triple 5-HT_1A, 5-HT₇, and 5-HT₃ Receptor Antagonist—Reverses Depressive-Like Behaviors in Mouse Model of Depression Induced by Corticosterone

Simultaneous quantification of PGI2 and TXA2 metabolites in plasma and urine in NO-deficient mice by a novel UHPLC/MS/MS method

Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension

The antidepressant-like activity of 6-methoxy-2-[4-(2-methoxyphenyl)piperazin-1-yl]-9H-xanthen-9-one involves serotonergic 5-HT1A and 5-HT2A/C receptors activation

Filter options

Publication date

Content availability

Publication type

Publication language

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Maria Walczak

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Publication type

Publication language

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options