Search results for: Hanna Billert

Items from 1 to 6 out of 6 results

article

Population analysis to assess the influence of age and body weight on pharmacokinetics and pharmacodynamics of dexmedetomidine in New Zealand White rabbits

Justyna Warzybok, Agnieszka Bienert, Agnieszka Borsuk‐De Moor, Włodzimierz Płotek, more

Biopharmaceutics & Drug Disposition > 41 > 7 > 307 - 316

The purpose of this work was i) to develop a population pharmacokinetic (PK) and pharmacodynamic (PD) model of dexmedetomidine (DEX) in New Zealand White rabbits, ii) to investigate the influence of the age and weight of the animals on the model parameters, and iii) to assess the linearity of DEX PKs in the examined dose range. This was a prospective, crossover study, using a total of 18 New Zealand...

article

Nitric oxide modulates redox-mediated defense in potato challenged with Phytophthora infestans

Dariusz Abramowski, Magdalena Arasimowicz-Jelonek, Karolina Izbiańska, Hanna Billert, more

European Journal of Plant Pathology > 2015 > 143 > 2 > 237-260

In our experimental approach we investigated how post-infection nitric oxide-dependent signaling activated in potato leaves was related to defense against avirulent (avr) and virulent (vr) races of Phytophthora infestans. Results revealed that only in an incompatible response, early NO and superoxide (O₂ ^•-) generation led to peroxynitrite (ONOO⁻) formation and together with hydrogen peroxide (H₂O...

article

Normoergic NO-dependent changes, triggered by a SAR inducer in potato, create more potent defense responses to Phytophthora infestans

Łukasz Janus, Grzegorz Milczarek, Magdalena Arasimowicz-Jelonek, Dariusz Abramowski, more

Plant Science > 2013 > 211 > Complete > 23-34

In our experimental approach we examined how potato leaves exposed to a chemical agent might induce nitric oxide (NO) dependent biochemical modifications for future mobilization of an effective resistance to Phytophthora infestans. After potato leaf treatment with one of the following SAR inducers, i.e. β-aminobutyric acid (BABA), 2,6-dichloroisonicotinic acid (INA) or Laminarin, we observed enhanced...

article

Synthesis, characterization, photochemical properties and cytotoxicity of the novel porphyrazine functionalized with nitroimidazolylbutylsulfanyl groups

Sebastian Lijewski, Jaroslaw Piskorz, Malgorzata Kucinska, Marcin Wierzchowski, more

Inorganic Chemistry Communications > 2013 > 29 > Complete > 97-100

A novel porphyrazine analog possessing nitroimidazolylbutylsulfanyl groups was synthesized and characterized using UV–Vis, IR, MS MALDI and various NMR techniques. In addition, a computational model following the Density Functional Theory method (DFT) was applied to analyze the FT IR spectrum. Potential photosensitizing activity of the novel porphyrazine was evaluated by measuring its ability to generate...

article

Influence of non-irradiated and ultraviolet-A-irradiated N,N-dialanyl protoporphyrin and diarginine diprotoporphyrinate on the neutrophil respiratory burst in vitro

Andrzej Bugaj, Hanna Billert, Iwona Krawiec, Sylwia Żądłowska

Photodiagnosis and Photodynamic Therapy > 2006 > 3 > 2 > 106-111

N,N-Dialanyl protoporphyrin (PP(Ala) ₂ ) and diarginine diprotoporphyrinate (PP(Arg) ₂ ) are porphyrin photosensitizers that are currently being used in the photodynamic therapy (PDT) of cancer. In the present study, the effects of these agents on the neutrophil respiratory burst in vitro were investigated. In the case of non-stimulated neutrophils, the respiratory burst was significantly...

article

Oxidative metabolism of peripheral blood neutrophils in experimental acute hypercapnia in the mechanically ventilated rabbit

Hanna Billert, Leon Drobnik, Danuta Podstawska, Marcin Wl̷odarczyk, more

Vascular Pharmacology > 2003 > 40 > 2 > 119-125

Background and aim: The aim of this study was to investigate the effect of acute hypercapnia due to the mechanical hypoventilation on the oxidative metabolism of peripheral blood neutrophils in the rabbit. Methods: The study was performed on 24 Chinchilla rabbits, randomized into normo- and hypercapnia groups (P _a CO ₂ between 9 and 11 kPa over 180 min). At the baseline point and after...

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Search results for: Hanna Billert

Population analysis to assess the influence of age and body weight on pharmacokinetics and pharmacodynamics of dexmedetomidine in New Zealand White rabbits

Nitric oxide modulates redox-mediated defense in potato challenged with Phytophthora infestans

Normoergic NO-dependent changes, triggered by a SAR inducer in potato, create more potent defense responses to Phytophthora infestans

Synthesis, characterization, photochemical properties and cytotoxicity of the novel porphyrazine functionalized with nitroimidazolylbutylsulfanyl groups

Influence of non-irradiated and ultraviolet-A-irradiated N,N-dialanyl protoporphyrin and diarginine diprotoporphyrinate on the neutrophil respiratory burst in vitro

Oxidative metabolism of peripheral blood neutrophils in experimental acute hypercapnia in the mechanically ventilated rabbit

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