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Activation of CD40, a member of the tumor necrosis factor receptor (TNF‐R) family, results in growth inhibition or apoptosis in some tumor cells, making CD40 a potential antitumor therapeutic target. Although it is known that CD40 is able to induce tumor necrosis factor‐alpha (TNF‐α) secretion and potentiate cisplatin’s anticancer activity, whether TNF‐α induction is involved in sensitizing cisplatin...
Tremendous effort has been made to improve the anticancer value of tumor necrosis factor (TNF). In this study, we show that wogonin, a flavonoid isolated from Huang‐Qin (Scutellaria baicalensis), synergistically sensitizes cancer cells derived from the cervix, ovary and lung to TNF‐induced apoptosis, which was associated with inhibition of catalase activity and an increase of cellular hydrogen peroxide...
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