Search results for: I.M.C.M. Rietjens

Items from 1 to 20 out of 33 results

article

Impact of lincosamides antibiotics on the composition of the rat gut microbiota and the metabolite profile of plasma and feces

C. Behr, S. Ramírez-Hincapié, H.J. Cameron, V. Strauss, more

Toxicology Letters > 2018 > 296 > C > 139-151

The importance of the gut microorganisms and their wide range of interactions with the host are well-acknowledged. In this study, lincomycin and clindamycin were used to modulate microbial communities of Wistar rats to gain a comprehensive understanding of the implications of microbiome alterations. A metabolomics approach and taxonomic profiling were applied to characterize the effects of these antibiotics...

article

Microbiome-related metabolite changes in gut tissue, cecum content and feces of rats treated with antibiotics

C. Behr, S. Sperber, X. Jiang, V. Strauss, more

Toxicology and Applied Pharmacology > 2018 > 355 > C > 198-210

The metabolic functionality of the gut microbiota contributes to the metabolism and well-being of its host, although detailed insight in the microbiota's metabolism is lacking. Omics technologies could facilitate unraveling metabolism by the gut microbiota.In this study, we performed metabolite profiling of different matrices of the gut, after antibiotic treatment of rats in order to evaluate metabolite...

article

Dose-dependent DNA adduct formation by cinnamaldehyde and other food-borne α,β-unsaturated aldehydes predicted by physiologically based in silico modelling

R. Kiwamoto, D. Ploeg, I.M.C.M. Rietjens, A. Punt

Toxicology in Vitro > 2016 > 31 > C > 114-125

Genotoxicity of α,β-unsaturated aldehydes shown in vitro raises a concern for the use of the aldehydes as food flavourings, while at low dose exposures the formation of DNA adducts may be prevented by detoxification. Unlike many α,β-unsaturated aldehydes for which in vivo data are absent, cinnamaldehyde was shown to be not genotoxic or carcinogenic in vivo. The present study aimed at comparing dose-dependent...

article

Deconjugation of soy isoflavone glucuronides needed for estrogenic activity

M.A. Islam, R. Bekele, J.H.J. vanden Berg, Y. Kuswanti, more

Toxicology in Vitro > 2015 > 29 > 4 > 706-715

Soy isoflavones (SIF) are present in the systemic circulation as conjugated forms of which the estrogenic potency is not yet clear. The present study provides evidence that the major SIF glucuronide metabolites in blood, genistein-7-O-glucuronide (GG) and daidzein-7-O-glucuronide (DG), only become estrogenic after deconjugation. The estrogenic potencies of genistein (Ge), daidzein (Da), GG and DG...

article

An integrated QSAR-PBK/D modelling approach for predicting detoxification and DNA adduct formation of 18 acyclic food-borne α,β-unsaturated aldehydes

R. Kiwamoto, A. Spenkelink, I.M.C.M. Rietjens, A. Punt

Toxicology and Applied Pharmacology > 2015 > 282 > 1 > 108-117

Acyclic α,β-unsaturated aldehydes present in food raise a concern because the α,β-unsaturated aldehyde moiety is considered a structural alert for genotoxicity. However, controversy remains on whether in vivo at realistic dietary exposure DNA adduct formation is significant. The aim of the present study was to develop physiologically based kinetic/dynamic (PBK/D) models to examine dose-dependent detoxification...

article

Human T47D-ERβ breast cancer cells with tetracycline-dependent ERβ expression reflect ERα/ERβ ratios in rat and human breast tissue

N.M. Evers, T.M.C. van de Klundert, Y.M. van Aesch, S. Wang, more

Toxicology in Vitro > 2013 > 27 > 6 > 1753-1761

T47D-ERβ breast cancer cells with tetracycline-dependent ERβ expression and constant ERα expression can be used to investigate effects of varying ERα/ERβ ratios on estrogen-induced cellular responses. This study defines conditions at which ERα/ERβ ratios in T47D-ERβ cells best mimic ERα/ERβ ratios in breast and other estrogen-sensitive tissues in vivo in rat as well as in human.Protein and mRNA levels...

article

Safety assessment of smoke flavouring primary products by the European Food Safety Authority

A. Theobald, D. Arcella, A. Carere, C. Croera, more

Trends in Food Science & Technology > 2012 > 27 > 2 > 97-108

This paper summarises the safety assessments of eleven smoke flavouring primary products evaluated by the European Food Safety Authority (EFSA). Data on chemical composition, content of polyaromatic hydrocarbons and results of genotoxicity tests and subchronic toxicity studies are presented and discussed. The smoke flavourings vary in their contents of identified constituents; none of them exceeded...

article

Matrix modulation of the bioactivation of estragole by different alkenylbenzenes-containing herbs and spices and physiologically-based biokinetic modeling of possible in vivo effects

W. Alhusainy, S. van den Berg, A. Campana, A. Paini, more

Toxicology > 2011 > 290 > 2-3 > 147-148

article

The FEMA GRAS assessment of aliphatic and aromatic terpene hydrocarbons used as flavor ingredients

T.B. Adams, C. Lucas Gavin, M.M. McGowen, W.J. Waddell, more

Food and Chemical Toxicology > 2011 > 49 > 10 > 2471-2494

This publication is the thirteenth in a series of safety evaluations performed by the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA). In 1993, the Panel initiated a comprehensive program to re-evaluate the safety of more than 1700 GRAS flavoring substances under conditions of intended use. Since then, the number of flavoring substances has grown to more than 2600 substances...

article

Update of risk assessments of main marine biotoxins in the European Union

I. Paredes, I.M.C.M. Rietjens, J.M. Vieites, A.G. Cabado

Toxicon > 2011 > 58 > 4 > 336-354

This review is an up-to-date compilation of the available literature, including scientific papers, reviews, and EFSA’s opinions, on toxicity and risk assessment data on the main marine biotoxins of importance in the European Union, including the legislated ones and the ones of recent appearance which are not legislated. Information about the hazard identification and hazard characterisation of okadaic...

article

A physiologically based kinetic (PBK) model for safrole bioactivation and detoxification in rat and comparison to those for estragole and methyleugenol

E. Martati, M. Boersma, A. Spenkelink, D. Khadka, more

Toxicology Letters > 2011 > 205 > Supplement > S190

article

Physiologically based kinetic modeling of bioactivation and detoxification of the alkenylbenzene methyleugenol in human as compared with rat

A.A. Al-Subeihi, A. Spenkelink, A. Punt, M. Boersma, more

Toxicology Letters > 2011 > 205 > Supplement > S152

article

Re-evaluation of natural food colours—State of the art

B. Dusemund, D. Parent-Massin, A. Mortensen, I.M.C.M. Rietjens

Toxicology Letters > 2011 > 205 > Supplement > S35

article

Matrix modulation of the bioactivation of estragole by different alkenylbenzene-containing herbs and spices and physiologically based biokinetic modeling of possible in vivo effects

W. Alhusainy, S. van Den berg, A. Punt, G. Scholz, more

Toxicology Letters > 2011 > 205 > Supplement > S40

article

Effects of C60 nanoparticle exposure on earthworms (Lumbricus rubellus) and implications for population dynamics

M.J.C. van der Ploeg, J.M. Baveco, A. van der Hout, R. Bakker, more

Environmental Pollution > 2011 > 159 > 1 > 198-203

Effects of C ₆₀ nanoparticles (nominal concentrations 0, 15.4 and 154mg/kg soil) on mortality, growth and reproduction of Lumbricus rubellus earthworms were assessed. C ₆₀ exposure had a significant effect on cocoon production, juvenile growth rate and mortality. These endpoints were used to model effects on the population level. This demonstrated reduced population growth rate with...

article

Application of bioassays in toxicological hazard, risk and impact assessments of dredged sediments

C.A. Schipper, I.M.C.M. Rietjens, R.M. Burgess, A.J. Murk

Marine Pollution Bulletin > 2010 > 60 > 11 > 2026-2042

Given the potential environmental consequences of dumped dredged harbour sediments it is vital to establish the potential risks from exposure before disposal at sea. Currently, European legislation for disposal of contaminated sediments at sea is based on chemical analysis of a limited number of well-known contaminants for which maximum acceptable concentrations, action levels (ALs), have been set...

article

Superinduction of estrogen receptor mediated gene expression in luciferase based reporter gene assays is mediated by a post-transcriptional mechanism

A.M. Sotoca, T.F.H. Bovee, W. Brand, N. Velikova, more

Journal of Steroid Biochemistry and Molecular Biology > 2010 > 122 > 4 > 204-211

Several estrogenic compounds including the isoflavonoid genistein have been reported to induce a higher maximal response than the natural estrogen 17β-estradiol in in vitro luciferase based reporter gene bioassays for testing estrogenicity. The phenomenon has been referred to as superinduction. The mechanism underlying this effect and thus also its biological relevance remain to be elucidated. In...

article

Corrigendum to “Identification of nevadensin as an important herb-based constituent inhibiting estragole bioactivation and physiology-based biokinetic modeling of its possible in vivo effect” [Toxicology and Applied Pharmacology (2010) 179–190]

W. Alhusainy, A. Paini, A. Punt, J. Louisse, more

Toxicology and Applied Pharmacology > 2010 > 247 > 3 > 250

article

Identification of nevadensin as an important herb-based constituent inhibiting estragole bioactivation and physiology-based biokinetic modeling of its possible in vivo effect

W. Alhusainy, A. Paini, A. Punt, J. Louisse, more

Toxicology and Applied Pharmacology > 2010 > 245 > 2 > 179-190

Estragole is a natural constituent of several herbs and spices including sweet basil. In rodent bioassays, estragole induces hepatomas, an effect ascribed to estragole bioactivation to 1′-sulfooxyestragole resulting in DNA adduct formation. The present paper identifies nevadensin as a basil constituent able to inhibit DNA adduct formation in rat hepatocytes exposed to the proximate carcinogen 1′-hydroxyestragole...

article

Corrigendum to: ‘‘The FEMA GRAS assessment of a,b-unsaturated aldehydes and related substances used as flavor ingredients” [Food and Chemical Toxicology 46 (2008) 2935–2967]

T.B. Adams, C. Lucas Gavin, S.V. Taylor, W.J. Waddell, more

Food and Chemical Toxicology > 2009 > 47 > 10 > 2686

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Search results for: I.M.C.M. Rietjens

Impact of lincosamides antibiotics on the composition of the rat gut microbiota and the metabolite profile of plasma and feces

Microbiome-related metabolite changes in gut tissue, cecum content and feces of rats treated with antibiotics

Dose-dependent DNA adduct formation by cinnamaldehyde and other food-borne α,β-unsaturated aldehydes predicted by physiologically based in silico modelling

Deconjugation of soy isoflavone glucuronides needed for estrogenic activity

An integrated QSAR-PBK/D modelling approach for predicting detoxification and DNA adduct formation of 18 acyclic food-borne α,β-unsaturated aldehydes

Human T47D-ERβ breast cancer cells with tetracycline-dependent ERβ expression reflect ERα/ERβ ratios in rat and human breast tissue

Safety assessment of smoke flavouring primary products by the European Food Safety Authority

Matrix modulation of the bioactivation of estragole by different alkenylbenzenes-containing herbs and spices and physiologically-based biokinetic modeling of possible in vivo effects

The FEMA GRAS assessment of aliphatic and aromatic terpene hydrocarbons used as flavor ingredients

Update of risk assessments of main marine biotoxins in the European Union

A physiologically based kinetic (PBK) model for safrole bioactivation and detoxification in rat and comparison to those for estragole and methyleugenol

Physiologically based kinetic modeling of bioactivation and detoxification of the alkenylbenzene methyleugenol in human as compared with rat

Re-evaluation of natural food colours—State of the art

Matrix modulation of the bioactivation of estragole by different alkenylbenzene-containing herbs and spices and physiologically based biokinetic modeling of possible in vivo effects

Effects of C60 nanoparticle exposure on earthworms (Lumbricus rubellus) and implications for population dynamics

Application of bioassays in toxicological hazard, risk and impact assessments of dredged sediments

Superinduction of estrogen receptor mediated gene expression in luciferase based reporter gene assays is mediated by a post-transcriptional mechanism

Corrigendum to “Identification of nevadensin as an important herb-based constituent inhibiting estragole bioactivation and physiology-based biokinetic modeling of its possible in vivo effect” [Toxicology and Applied Pharmacology (2010) 179–190]

Identification of nevadensin as an important herb-based constituent inhibiting estragole bioactivation and physiology-based biokinetic modeling of its possible in vivo effect

Corrigendum to: ‘‘The FEMA GRAS assessment of a,b-unsaturated aldehydes and related substances used as flavor ingredients” [Food and Chemical Toxicology 46 (2008) 2935–2967]

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