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In this work we evaluate the ability of PLS in generalizing to unseen clinical cohorts when applied to the analysis of the joint variation between genotype and phenotype in Alzheimer's disease (AD). The model is trained on single-nucleotide polymorphisms (SNPs) and brain volumes obtained from the ADNI database for a large cohort of healthy individuals and AD patients, and validated on the ADNI MCI...
One of the basic components of diffeomorphic image registration algorithms based on velocity fields is the numerical method used to integrate velocity parameters and obtain spatial transformations as displacement fields. When the input velocity field does not depend on the time parameter, the solution is often referred to as the Lie exponential of the velocity field. In this work, we present an integration...
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