Search results for: Christopher Linington

Items from 1 to 20 out of 33 results

article

Fibroblast growth factor 9 (FGF9)‐mediated neurodegeneration: Implications for progressive multiple sclerosis?

Katja Thümmler, Claudia Wrzos, Jonas Franz, Daniel McElroy, more

Neuropathology and Applied Neurobiology > 49 > 5 > n/a - n/a

Aims Fibroblast growth factor (FGF) signalling is dysregulated in multiple sclerosis (MS) and other neurological and psychiatric conditions, but there is little or no consensus as to how individual FGF family members contribute to disease pathogenesis. Lesion development in MS is associated with increased expression of FGF1, FGF2 and FGF9, all of which modulate remyelination in a variety of experimental...

article

Oxygen treatment reduces neurological deficits and demyelination in two animal models of multiple sclerosis

Mario Amatruda, Kate Harris, Alina Matis, Andrew L. Davies, more

Neuropathology and Applied Neurobiology > 49 > 1 > n/a - n/a

Aims The objective of the study is to explore the importance of tissue hypoxia in causing neurological deficits and demyelination in the inflamed CNS, and the value of inspiratory oxygen treatment, using both active and passive experimental autoimmune encephalomyelitis (EAE). Methods Normobaric oxygen treatment was administered to Dark Agouti rats with either active or passive EAE, compared with...

article

Oligodendrocytes are susceptible to Zika virus infection in a mouse model of perinatal exposure: Implications for CNS complications

Verena Schultz, Jennifer A. Barrie, Claire L. Donald, Colin L. Crawford, more

Glia > 69 > 8 > 2023 - 2036

Some children with proven intrauterine Zika virus (ZIKV) infection who were born asymptomatic subsequently manifested neurodevelopmental delays, pointing to impairment of development perinatally and postnatally. To model this, we infected postnatal day (P) 5–6 (equivalent to the perinatal period in humans) susceptible mice with a mammalian cell‐propagated ZIKV clinical isolate from the Brazilian outbreak...

article

Nimodipine Reduces Dysfunction and Demyelination in Models of Multiple Sclerosis

Roshni A. Desai, Andrew L. Davies, Natalie Del Rossi, Mohamed Tachrount, more

Annals of Neurology > 88 > 1 > 123 - 136

Objective Treatment of relapses in multiple sclerosis (MS) has not advanced beyond steroid use, which reduces acute loss of function, but has little effect on residual disability. Acute loss of function in an MS model (experimental autoimmune encephalomyelitis [EAE]) is partly due to central nervous system (CNS) hypoxia, and function can promptly improve upon breathing oxygen. Here, we investigate...

article

Preclinical stress originates in the rat optic nerve head during development of autoimmune optic neuritis

Aleksandar Stojic, Jovana Bojcevski, Sarah K. Williams, Carlos Bas‐Orth, more

Glia > 67 > 3 > 512 - 524

Optic neuritis is a common manifestation of multiple sclerosis, an inflammatory demyelinating disease of the CNS. Although it is the presenting symptom in many cases, the initial events are currently unknown. However, in the earliest stages of autoimmune optic neuritis in rats, pathological changes are already apparent such as microglial activation and disturbances in myelin ultrastructure of the...

article

Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected

Stephanie L. Cumberworth, Jennifer A. Barrie, Madeleine E. Cunningham, Daniely Paulino Gomes de Figueiredo, more

Acta Neuropathologica Communications > 2017 > 5 > 1 > 1-16

The recent global outbreak of Zika virus (ZIKV) infection has been linked to severe neurological disorders affecting the peripheral and central nervous systems (PNS and CNS, respectively). The pathobiology underlying these diverse clinical phenotypes are the subject of intense research; however, even the principal neural cell types vulnerable to productive Zika infection remain poorly characterised...

article

Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis

Nielsen Lagumersindez-Denis, Claudia Wrzos, Matthias Mack, Anne Winkler, more

Acta Neuropathologica > 2017 > 134 > 1 > 15-34

Cortical demyelination is a widely recognized hallmark of multiple sclerosis (MS) and correlate of disease progression and cognitive decline. The pathomechanisms initiating and driving gray matter damage are only incompletely understood. Here, we determined the infiltrating leukocyte subpopulations in 26 cortical demyelinated lesions of biopsied MS patients and assessed their contribution to cortical...

article

MOG-induced experimental autoimmune encephalomyelitis in the rat species triggers anti-neurofascin antibody response that is genetically regulated

Sevasti Flytzani, Andre Ortlieb Guerreiro-Cacais, Marie N’diaye, Maren Lindner, more

Journal of Neuroinflammation > 2015 > 12 > 1 > 1-10

Background Ιn multiple sclerosis (MS), axonal damage leads to permanent neurological disabilities and the spreading of the autoimmune response to axonal antigens is implicated in disease progression. Experimental autoimmune encephalomyelitis (EAE) provides an animal model that mimics MS. Using different EAE models, we investigated the pathophysiological basis of epitope spreading to neurofascin, a...

article

Non-lytic autoantibody mediated effects on myelination are associated with increased pro-inflammatory chemokine expression

Tiia Semenoff, Katie Chapple, Christopher Linington, Katja Thuemmler

Journal of Neuroimmunology > 2014 > 275 > 1-2 > 107

article

A dual role for fibroblast growth factor 9 in multiple sclerosis: Inhibition of (re)myelination and induction of pro-inflammatory environment

Katja Thuemmler, Daniel Mcelroy, Maren Lindner, Ariel Arthur, more

Journal of Neuroimmunology > 2014 > 275 > 1-2 > 107-108

article

Loss of function due to neuroinflammation: A role for oxygen therapy?

Mario Amatruda, Alina Matis, Maren Lindner, Christopher Linington, more

Journal of Neuroimmunology > 2014 > 275 > 1-2 > 134-135

article

Fibroblast growth factor 9 and its downstream regulators in the pathogenesis of multiple sclerosis

Daniel Mcelroy, Katja Thuemmler, Maren Lindner, Cornelia Schuh, more

Journal of Neuroimmunology > 2014 > 275 > 1-2 > 104-105

article

B cell antigen presentation is sufficient to drive neuro-inflammation in an animal model of multiple sclerosis

Chelsea R. Parker, Angela S. Archambault, Julia Sim, Stephen T. Ferris, more

Journal of Neuroimmunology > 2014 > 275 > 1-2 > 15-16

article

Neurological deficits caused by tissue hypoxia in neuroinflammatory disease

Andrew L. Davies, Roshni A. Desai, Peter S. Bloomfield, Peter R. McIntosh, more

Annals of Neurology > 74 > 6 > 815 - 825

ObjectiveTo explore the presence and consequences of tissue hypoxia in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). MethodsEAE was induced in Dark Agouti rats by immunization with recombinant myelin oligodendrocyte glycoprotein and adjuvant. Tissue hypoxia was assessed in vivo using 2 independent methods: an immunohistochemical probe administered intravenously,...

article

Neurofascin 186 specific autoantibodies induce axonal injury and exacerbate disease severity in experimental autoimmune encephalomyelitis

Maren Lindner, Judy King Man Ng, Sonja Hochmeister, Edgar Meinl, more

Experimental Neurology > 2013 > 247 > Complete > 259-266

Axonal injury is considered the major cause of chronic disability in multiple sclerosis (MS) patients, however the mechanisms behind remain still unclear. Recently, it was demonstrated that autoantibodies against Neurofascin, a cell adhesion molecule within the adult nervous system, can contribute to the development of axonal pathology in some patients.We compared the ability of the two different...

article

IL‐33 attenuates EAE by suppressing IL‐17 and IFN‐γ production and inducing alternatively activated macrophages

Hui‐Rong Jiang, Marija Milovanović, Debbie Allan, Wanda Niedbala, more

European Journal of Immunology > 42 > 7 > 1804 - 1814

Interleukin (IL)‐33, a member of the IL‐1 cytokine family, is an important modulator of the immune system associated with several immune‐mediated disorders. High levels of IL‐33 are expressed by the central nervous system (CNS) suggesting a potential role of IL‐33 in autoimmune CNS diseases. We have investigated the expression and function of IL‐33 in the development of experimental autoimmune encephalomyelitis...

article

Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis

Kathryn M. Brennan, Francesc Galban-Horcajo, Simon Rinaldi, Colin P. O'Leary, more

Journal of Neuroimmunology > 2011 > 238 > 1-2 > 87-95

The presence of oligoclonal bands of IgG (OCB) in cerebrospinal fluid (CSF) is used to establish a diagnosis of multiple sclerosis (MS), but their specificity has remained an enigma since its first description over forty years ago. We now report that the use of lipid arrays identifies heteromeric complexes of myelin derived lipids as a prominent target for this intrathecal B cell response.

article

B‐cell activation influences T‐cell polarization and outcome of anti‐CD20 B‐cell depletion in central nervous system autoimmunity

Martin S. Weber, Thomas Prod'homme, Juan C. Patarroyo, Nicolas Molnarfi, more

Annals of Neurology > 68 > 3 > 369 - 383

ObjectiveClinical studies indicate that anti‐CD20 B‐cell depletion may be an effective multiple sclerosis (MS) therapy. We investigated mechanisms of anti‐CD20‐mediated immune modulation using 2 paradigms of experimental autoimmune encephalomyelitis (EAE). MethodsMurine EAE was induced by recombinant myelin oligodendrocyte glycoprotein (rMOG), a model in which B cells are considered to contribute...

article

Recombinant TCR Ligand Reverses Clinical Signs and CNS Damage of EAE Induced by Recombinant Human MOG

Sushmita Sinha, Sandhya Subramanian, Ashley Emerson-Webber, Maren Lindner, more

Journal of Neuroimmune Pharmacology > 2010 > 5 > 2 > 231-239

Increasing evidence suggests that in addition to T cell-dependent effector mechanisms, autoantibodies are also involved in the pathogenesis of MS, including demyelinating antibodies specific for myelin oligodendrocyte glycoprotein (MOG). Our previous studies have demonstrated that recombinant T cell receptor ligands (RTLs) are very effective for treating T cell-mediated experimental autoimmune encephalomyelitis...

article

DNA vaccination efficiently induces antibodies to Nogo-A and does not exacerbate experimental autoimmune encephalomyelitis

Carole Bourquin, Marjan E. van der Haar, David Anz, Nadja Sandholzer, more

European Journal of Pharmacology > 2008 > 588 > 1 > 99-105

Antibodies against the neurite outgrowth inhibitor Nogo-A enhance axonal regeneration following spinal cord injury. However, antibodies directed against myelin components can also enhance CNS inflammation. The present study was designed to assess the efficacy of DNA vaccination for generating antibodies against Nogo-A and to study their pathogenic potential in a mouse model for multiple sclerosis...

Publication date

Last 3 years (2)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

INFONA - science communication portal

Search results for: Christopher Linington

Fibroblast growth factor 9 (FGF9)‐mediated neurodegeneration: Implications for progressive multiple sclerosis?

Oxygen treatment reduces neurological deficits and demyelination in two animal models of multiple sclerosis

Oligodendrocytes are susceptible to Zika virus infection in a mouse model of perinatal exposure: Implications for CNS complications

Nimodipine Reduces Dysfunction and Demyelination in Models of Multiple Sclerosis

Preclinical stress originates in the rat optic nerve head during development of autoimmune optic neuritis

Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected

Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis

MOG-induced experimental autoimmune encephalomyelitis in the rat species triggers anti-neurofascin antibody response that is genetically regulated

Non-lytic autoantibody mediated effects on myelination are associated with increased pro-inflammatory chemokine expression

A dual role for fibroblast growth factor 9 in multiple sclerosis: Inhibition of (re)myelination and induction of pro-inflammatory environment

Loss of function due to neuroinflammation: A role for oxygen therapy?

Fibroblast growth factor 9 and its downstream regulators in the pathogenesis of multiple sclerosis

B cell antigen presentation is sufficient to drive neuro-inflammation in an animal model of multiple sclerosis

Neurological deficits caused by tissue hypoxia in neuroinflammatory disease

Neurofascin 186 specific autoantibodies induce axonal injury and exacerbate disease severity in experimental autoimmune encephalomyelitis

IL‐33 attenuates EAE by suppressing IL‐17 and IFN‐γ production and inducing alternatively activated macrophages

Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis

B‐cell activation influences T‐cell polarization and outcome of anti‐CD20 B‐cell depletion in central nervous system autoimmunity

Recombinant TCR Ligand Reverses Clinical Signs and CNS Damage of EAE Induced by Recombinant Human MOG

DNA vaccination efficiently induces antibodies to Nogo-A and does not exacerbate experimental autoimmune encephalomyelitis

Filter options

Publication date

Content availability

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Christopher Linington

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options