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The use of cytotoxic T lymphocyte (CTL)-inducing vaccines could afford both homo- and heterosubtypic immunity. However, amino acid variation in CTL epitopes associated with escape from CTL-mediated immunity might undermine the use of these vaccines. To assess the impact of amino acid substitutions in highly conserved epitopes on viral fitness and recognition by specific CTL, we performed a mutational...
Recently, an HLA-B*3501-restricted cytotoxic T-lymphocytes (CTL) epitope in the nucleoprotein (NP 418-426 ) of influenza A viruses was identified, which exhibited a high degree of variability. In the present study, the recognition of epitope variants by human cytotoxic T-lymphocytes (CTL) was investigated. Human CD8+ CTL clones were specific for NP 41...
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